Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis
Aberrant glycosylation plays a critical role in tumor aggressiveness, progression, and metastasis. Emerging evidence associates cancer initiation and metastasis to the enrichment of cancer stem cells (CSCs). Several universal markers have been identified for CSCs characterization; however, a specifi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-08-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1476558618301817 |
| _version_ | 1811269556531888128 |
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| author | Srikanth Barkeer Seema Chugh Surinder K Batra Moorthy P. Ponnusamy |
| author_facet | Srikanth Barkeer Seema Chugh Surinder K Batra Moorthy P. Ponnusamy |
| author_sort | Srikanth Barkeer |
| collection | DOAJ |
| description | Aberrant glycosylation plays a critical role in tumor aggressiveness, progression, and metastasis. Emerging evidence associates cancer initiation and metastasis to the enrichment of cancer stem cells (CSCs). Several universal markers have been identified for CSCs characterization; however, a specific marker has not yet been identified for different cancer types. Specific glycosylation variation plays a major role in the progression and metastasis of different cancers. Interestingly, many of the CSC markers are glycoproteins and undergo differential glycosylation. Given the importance of CSCs and altered glycosylation in tumorigenesis, the present review will discuss current knowledge of altered glycosylation of CSCs and its application in cancer research. |
| first_indexed | 2024-04-12T21:44:05Z |
| format | Article |
| id | doaj.art-253199de21454c809382681013622070 |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-04-12T21:44:05Z |
| publishDate | 2018-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-253199de21454c8093826810136220702022-12-22T03:15:40ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862018-08-01208813825Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and MetastasisSrikanth Barkeer0Seema Chugh1Surinder K Batra2Moorthy P. Ponnusamy3Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NEDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NEDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA; Address all correspondence to: Moorthy P. Ponnusamy, PhD, or Surinder K. Batra, PhD, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, 68198-5870, U.S.A.Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE; Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA; Address all correspondence to: Moorthy P. Ponnusamy, PhD, or Surinder K. Batra, PhD, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, 68198-5870, U.S.A.Aberrant glycosylation plays a critical role in tumor aggressiveness, progression, and metastasis. Emerging evidence associates cancer initiation and metastasis to the enrichment of cancer stem cells (CSCs). Several universal markers have been identified for CSCs characterization; however, a specific marker has not yet been identified for different cancer types. Specific glycosylation variation plays a major role in the progression and metastasis of different cancers. Interestingly, many of the CSC markers are glycoproteins and undergo differential glycosylation. Given the importance of CSCs and altered glycosylation in tumorigenesis, the present review will discuss current knowledge of altered glycosylation of CSCs and its application in cancer research.http://www.sciencedirect.com/science/article/pii/S1476558618301817 |
| spellingShingle | Srikanth Barkeer Seema Chugh Surinder K Batra Moorthy P. Ponnusamy Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis Neoplasia: An International Journal for Oncology Research |
| title | Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis |
| title_full | Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis |
| title_fullStr | Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis |
| title_full_unstemmed | Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis |
| title_short | Glycosylation of Cancer Stem Cells: Function in Stemness, Tumorigenesis, and Metastasis |
| title_sort | glycosylation of cancer stem cells function in stemness tumorigenesis and metastasis |
| url | http://www.sciencedirect.com/science/article/pii/S1476558618301817 |
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