Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
The aim of this systematic review and meta-analysis is to summarize data on the effectiveness of Sildenafil supplementation for women undergoing assisted reproduction techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the effects of Sildenafil administration during infer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/19/4346 |
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| author | Loris Marin Alessandra Andrisani Luciana Bordin Francesco Dessole Marco Noventa Amerigo Vitagliano Giampiero Capobianco Guido Ambrosini |
| author_facet | Loris Marin Alessandra Andrisani Luciana Bordin Francesco Dessole Marco Noventa Amerigo Vitagliano Giampiero Capobianco Guido Ambrosini |
| author_sort | Loris Marin |
| collection | DOAJ |
| description | The aim of this systematic review and meta-analysis is to summarize data on the effectiveness of Sildenafil supplementation for women undergoing assisted reproduction techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the effects of Sildenafil administration during infertility treatments compared with a control group in infertile women. Outcomes evaluated were endometrial thickness (ETh) and the clinical pregnancy rate (CPR). The chemical pregnancy rate (ChPR) was also evaluated. Pooled results were expressed as the risk ratio (RR) or mean differences (MD) with a 95% confidence interval (95% CI). Women undergoing ovulation induction who received Sildenafil showed higher ETh and a higher CPR in comparison to controls. In this group, both the ETh and ChPR resulted in significantly higher values only with delayed start administration. Women undergoing fresh or frozen embryo transfer who received Sildenafil showed no significant advantages regarding ETh and CPR in comparison to controls. In this group, we found a significantly higher ChPR in women receiving Sildenafil. A subgroup analysis revealed significant advantages regarding ETh with oral administration for women undergoing fresh or frozen embryo transfer. Sildenafil therapy appears to improve endometrial thickness and pregnancy rate in women undergoing timed intercourses but it resulted not effective in IUI and IVF treatments. Further RCTs with rigorous methodology are still mandatory. |
| first_indexed | 2024-03-10T06:57:40Z |
| format | Article |
| id | doaj.art-2532c896329a4e47b2f2fb60db6ddaae |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T06:57:40Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2532c896329a4e47b2f2fb60db6ddaae2023-11-22T16:18:04ZengMDPI AGJournal of Clinical Medicine2077-03832021-09-011019434610.3390/jcm10194346Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsLoris Marin0Alessandra Andrisani1Luciana Bordin2Francesco Dessole3Marco Noventa4Amerigo Vitagliano5Giampiero Capobianco6Guido Ambrosini7Department of Women’s and Children’s Health, University of Padua, 35128 Padua, ItalyDepartment of Women’s and Children’s Health, University of Padua, 35128 Padua, ItalyDepartment of Molecular Medicine-Biological Chemistry, University of Padova, 35131 Padova, ItalyDepartment of Surgical, Microsurgical and Medical Sciences, Gynecologic and Obstetric Clinic, University of Sassari, 07100 Sassari, ItalyDepartment of Women’s and Children’s Health, University of Padua, 35128 Padua, ItalyDepartment of Women’s and Children’s Health, University of Padua, 35128 Padua, ItalyDepartment of Surgical, Microsurgical and Medical Sciences, Gynecologic and Obstetric Clinic, University of Sassari, 07100 Sassari, ItalyDepartment of Women’s and Children’s Health, University of Padua, 35128 Padua, ItalyThe aim of this systematic review and meta-analysis is to summarize data on the effectiveness of Sildenafil supplementation for women undergoing assisted reproduction techniques. This meta-analysis of randomized controlled trials (RCTs) evaluates the effects of Sildenafil administration during infertility treatments compared with a control group in infertile women. Outcomes evaluated were endometrial thickness (ETh) and the clinical pregnancy rate (CPR). The chemical pregnancy rate (ChPR) was also evaluated. Pooled results were expressed as the risk ratio (RR) or mean differences (MD) with a 95% confidence interval (95% CI). Women undergoing ovulation induction who received Sildenafil showed higher ETh and a higher CPR in comparison to controls. In this group, both the ETh and ChPR resulted in significantly higher values only with delayed start administration. Women undergoing fresh or frozen embryo transfer who received Sildenafil showed no significant advantages regarding ETh and CPR in comparison to controls. In this group, we found a significantly higher ChPR in women receiving Sildenafil. A subgroup analysis revealed significant advantages regarding ETh with oral administration for women undergoing fresh or frozen embryo transfer. Sildenafil therapy appears to improve endometrial thickness and pregnancy rate in women undergoing timed intercourses but it resulted not effective in IUI and IVF treatments. Further RCTs with rigorous methodology are still mandatory.https://www.mdpi.com/2077-0383/10/19/4346Sildenafilendometrial thicknesstimed intercourseintrauterine inseminationin vitro fertilization |
| spellingShingle | Loris Marin Alessandra Andrisani Luciana Bordin Francesco Dessole Marco Noventa Amerigo Vitagliano Giampiero Capobianco Guido Ambrosini Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Journal of Clinical Medicine Sildenafil endometrial thickness timed intercourse intrauterine insemination in vitro fertilization |
| title | Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full | Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_fullStr | Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_full_unstemmed | Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_short | Sildenafil Supplementation for Women Undergoing Infertility Treatments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials |
| title_sort | sildenafil supplementation for women undergoing infertility treatments a systematic review and meta analysis of randomized controlled trials |
| topic | Sildenafil endometrial thickness timed intercourse intrauterine insemination in vitro fertilization |
| url | https://www.mdpi.com/2077-0383/10/19/4346 |
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