Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis
BackgroundBiliary tract cancer (BTC) is a malignancy associated with unfavorable outcomes. Advanced BTC patients have a propensity to experience compromised immune and nutritional status as a result of obstructive jaundice and biliary inflammation. Currently, there is a lack of consensus on the impa...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-08-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1240008/full |
| _version_ | 1797741314143420416 |
|---|---|
| author | Zhuoran Liu Haoge Zhou Yu Zhou Menglin Yu Yonglang Cheng Jing Li |
| author_facet | Zhuoran Liu Haoge Zhou Yu Zhou Menglin Yu Yonglang Cheng Jing Li |
| author_sort | Zhuoran Liu |
| collection | DOAJ |
| description | BackgroundBiliary tract cancer (BTC) is a malignancy associated with unfavorable outcomes. Advanced BTC patients have a propensity to experience compromised immune and nutritional status as a result of obstructive jaundice and biliary inflammation. Currently, there is a lack of consensus on the impact of the Controlling Nutritional Status (CONUT) score in the context of BTC prognosis. The purpose of this study is to conduct a meta-analysis on the association between CONUT and the prognosis of patients suffering from BTC.MethodsA defined search strategy was implemented to search the PubMed, Embase, and Web of Science databases for eligible studies published until March 2023, with a focus on overall survival (OS), relapse-free survival/recurrence-free survival(RFS), and relevant clinical characteristics. The prognostic potential of the CONUT score was evaluated using hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs).ResultsIn this meta-analysis, a total of 1409 patients from China and Japan were involved in 9 studies. The results indicated that the CONUT score was significantly correlated with worse OS (HR=2.13, 95% CI 1.61-2.82, P<0.0001) and RFS (HR=1.83, 95% CI 1.44–2.31, P<0.0001) in patients with BTC. And, the analysis showed that a high CONUT score was significantly associated with clinical characteristics such as jaundice (OR=1.60, 95% CI=1.14–2.25, P=0.006), poorly differentiated tumor (OR=1.43, 95% CI=1.03–1.99, P=0.03), pT3 and 4 stage of the tumor (OR=1.87, 95% CI=1.30–2.68, P=0.0007), and complications of Clavien-Dindo classification grade IIIa or higher (OR=1.79, 95% CI=1.03–3.12, P=0.04).ConclusionThis meta-analysis indicates that a high CONUT score can serve as a significant prognostic indicator for survival outcomes among patients diagnosed with BTC. |
| first_indexed | 2024-03-12T14:25:01Z |
| format | Article |
| id | doaj.art-25380aa4604d4491a9907481eae204e5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-12T14:25:01Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-25380aa4604d4491a9907481eae204e52023-08-18T08:58:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-08-011310.3389/fonc.2023.12400081240008Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysisZhuoran Liu0Haoge Zhou1Yu Zhou2Menglin Yu3Yonglang Cheng4Jing Li5Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaBackgroundBiliary tract cancer (BTC) is a malignancy associated with unfavorable outcomes. Advanced BTC patients have a propensity to experience compromised immune and nutritional status as a result of obstructive jaundice and biliary inflammation. Currently, there is a lack of consensus on the impact of the Controlling Nutritional Status (CONUT) score in the context of BTC prognosis. The purpose of this study is to conduct a meta-analysis on the association between CONUT and the prognosis of patients suffering from BTC.MethodsA defined search strategy was implemented to search the PubMed, Embase, and Web of Science databases for eligible studies published until March 2023, with a focus on overall survival (OS), relapse-free survival/recurrence-free survival(RFS), and relevant clinical characteristics. The prognostic potential of the CONUT score was evaluated using hazard ratios (HRs) or odds ratios (ORs) with 95% confidence intervals (CIs).ResultsIn this meta-analysis, a total of 1409 patients from China and Japan were involved in 9 studies. The results indicated that the CONUT score was significantly correlated with worse OS (HR=2.13, 95% CI 1.61-2.82, P<0.0001) and RFS (HR=1.83, 95% CI 1.44–2.31, P<0.0001) in patients with BTC. And, the analysis showed that a high CONUT score was significantly associated with clinical characteristics such as jaundice (OR=1.60, 95% CI=1.14–2.25, P=0.006), poorly differentiated tumor (OR=1.43, 95% CI=1.03–1.99, P=0.03), pT3 and 4 stage of the tumor (OR=1.87, 95% CI=1.30–2.68, P=0.0007), and complications of Clavien-Dindo classification grade IIIa or higher (OR=1.79, 95% CI=1.03–3.12, P=0.04).ConclusionThis meta-analysis indicates that a high CONUT score can serve as a significant prognostic indicator for survival outcomes among patients diagnosed with BTC.https://www.frontiersin.org/articles/10.3389/fonc.2023.1240008/fullmeta-analysisbiliary tract cancerprognosiscontrolling nutritional status scoreclinical use |
| spellingShingle | Zhuoran Liu Haoge Zhou Yu Zhou Menglin Yu Yonglang Cheng Jing Li Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis Frontiers in Oncology meta-analysis biliary tract cancer prognosis controlling nutritional status score clinical use |
| title | Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis |
| title_full | Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis |
| title_fullStr | Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis |
| title_full_unstemmed | Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis |
| title_short | Prognostic impact of the Controlling Nutritional Status Score in patients with biliary tract cancer: a systematic review and meta-analysis |
| title_sort | prognostic impact of the controlling nutritional status score in patients with biliary tract cancer a systematic review and meta analysis |
| topic | meta-analysis biliary tract cancer prognosis controlling nutritional status score clinical use |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1240008/full |
| work_keys_str_mv | AT zhuoranliu prognosticimpactofthecontrollingnutritionalstatusscoreinpatientswithbiliarytractcancerasystematicreviewandmetaanalysis AT haogezhou prognosticimpactofthecontrollingnutritionalstatusscoreinpatientswithbiliarytractcancerasystematicreviewandmetaanalysis AT yuzhou prognosticimpactofthecontrollingnutritionalstatusscoreinpatientswithbiliarytractcancerasystematicreviewandmetaanalysis AT menglinyu prognosticimpactofthecontrollingnutritionalstatusscoreinpatientswithbiliarytractcancerasystematicreviewandmetaanalysis AT yonglangcheng prognosticimpactofthecontrollingnutritionalstatusscoreinpatientswithbiliarytractcancerasystematicreviewandmetaanalysis AT jingli prognosticimpactofthecontrollingnutritionalstatusscoreinpatientswithbiliarytractcancerasystematicreviewandmetaanalysis |