Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing
Interactions between epithelial and mesenchymal cells influence hair follicles (HFs) during embryonic development and skin regeneration following injury. Exchanging soluble molecules, altering key pathways, and extracellular matrix signal transduction are all part of the interplay between epithelial...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.863786/full |
| _version_ | 1811334179033448448 |
|---|---|
| author | Mei-Qi Mao Jing Jing Yu-Jie Miao Zhong-Fa Lv |
| author_facet | Mei-Qi Mao Jing Jing Yu-Jie Miao Zhong-Fa Lv |
| author_sort | Mei-Qi Mao |
| collection | DOAJ |
| description | Interactions between epithelial and mesenchymal cells influence hair follicles (HFs) during embryonic development and skin regeneration following injury. Exchanging soluble molecules, altering key pathways, and extracellular matrix signal transduction are all part of the interplay between epithelial and mesenchymal cells. In brief, the mesenchyme contains dermal papilla cells, while the hair matrix cells and outer root sheath represent the epithelial cells. This study summarizes typical epithelial–mesenchymal signaling molecules and extracellular components under the control of follicular stem cells, aiming to broaden our current understanding of epithelial–mesenchymal interaction mechanisms in HF regeneration and skin wound healing. |
| first_indexed | 2024-04-13T17:04:55Z |
| format | Article |
| id | doaj.art-2539ef27cbc145c2b22074a57a6dd82a |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-13T17:04:55Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-2539ef27cbc145c2b22074a57a6dd82a2022-12-22T02:38:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-04-01910.3389/fmed.2022.863786863786Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound HealingMei-Qi MaoJing JingYu-Jie MiaoZhong-Fa LvInteractions between epithelial and mesenchymal cells influence hair follicles (HFs) during embryonic development and skin regeneration following injury. Exchanging soluble molecules, altering key pathways, and extracellular matrix signal transduction are all part of the interplay between epithelial and mesenchymal cells. In brief, the mesenchyme contains dermal papilla cells, while the hair matrix cells and outer root sheath represent the epithelial cells. This study summarizes typical epithelial–mesenchymal signaling molecules and extracellular components under the control of follicular stem cells, aiming to broaden our current understanding of epithelial–mesenchymal interaction mechanisms in HF regeneration and skin wound healing.https://www.frontiersin.org/articles/10.3389/fmed.2022.863786/fullskinskin appendagesdermal papillaepithelial-mesenchymal interactionswound healinghair follicle growth cycle |
| spellingShingle | Mei-Qi Mao Jing Jing Yu-Jie Miao Zhong-Fa Lv Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing Frontiers in Medicine skin skin appendages dermal papilla epithelial-mesenchymal interactions wound healing hair follicle growth cycle |
| title | Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing |
| title_full | Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing |
| title_fullStr | Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing |
| title_full_unstemmed | Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing |
| title_short | Epithelial-Mesenchymal Interaction in Hair Regeneration and Skin Wound Healing |
| title_sort | epithelial mesenchymal interaction in hair regeneration and skin wound healing |
| topic | skin skin appendages dermal papilla epithelial-mesenchymal interactions wound healing hair follicle growth cycle |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.863786/full |
| work_keys_str_mv | AT meiqimao epithelialmesenchymalinteractioninhairregenerationandskinwoundhealing AT jingjing epithelialmesenchymalinteractioninhairregenerationandskinwoundhealing AT yujiemiao epithelialmesenchymalinteractioninhairregenerationandskinwoundhealing AT zhongfalv epithelialmesenchymalinteractioninhairregenerationandskinwoundhealing |