Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus
Yong Chen,1,* Anzhou Peng,2,* Yiqing Chen,1 Xianghua Kong,2 Linyang Li,2 Guangxiao Tang,3 Huifen Li,2 Yu Chen,4 Fan Jiang,2 Peibo Li,5 Qiu Zhang1 1Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 2De...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-01-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-of-tyg-index-with-ct-features-in-patients-with-tuberculosi-peer-reviewed-fulltext-article-IDR |
| _version_ | 1818942696438366208 |
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| author | Chen Y Peng A Chen Y Kong X Li L Tang G Li H Chen Y Jiang F Li P Zhang Q |
| author_facet | Chen Y Peng A Chen Y Kong X Li L Tang G Li H Chen Y Jiang F Li P Zhang Q |
| author_sort | Chen Y |
| collection | DOAJ |
| description | Yong Chen,1,* Anzhou Peng,2,* Yiqing Chen,1 Xianghua Kong,2 Linyang Li,2 Guangxiao Tang,3 Huifen Li,2 Yu Chen,4 Fan Jiang,2 Peibo Li,5 Qiu Zhang1 1Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 2Department of the Fifth Tuberculosis, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 3Department of Radiology, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 4Department of Medical Record Statistics Room, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 5Department of Physician Assistant, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiu Zhang; Peibo Li Tel +8613965015060; +8618709843713Email zhangqiu@ahmu.edu.cn; lipeibo013@163.comBackground: The purpose of this study was to investigate the association of the triglyceride glucose (TyG) index, a surrogate marker of insulin resistance (IR) with a high sensitivity of 96.5% and a specificity of 85.0% for the diagnosis of IR, with computed tomography (CT) features in patients with tuberculosis and diabetes mellitus.Methods: A total of 247 subjects were enrolled from July, 2020 to May, 2021. The basic clinical features and CT features were analyzed. In addition, multivariate logistic regression analysis models were employed to evaluate the association of the TyG indicator with CT features in participants.Results: In the quartile groups of TyG index, air bronchial sign detection rate was 11.7%, 14.5%, 23.2%, and 44.1%; large segmented leafy shadow detection rate was 27.9%, 40.6%, 46.4%, and 66.2%; thick-walled cavity was found in 38.2%, 43.4%, 57.9%, and 69.1%; the rate of multiple cavities was 17.6%, 27.5%, 36.2%, 52.9%; the rate of lymph node enlargement was 22.1%, 17.4%, 28.9%, and 38.2%, respectively. In addition, the positive relation with the TyG index and the prevalence of abnormal CT signs was observed in the fully adjusted model: TyG, per one-unit increase: air bronchial sign: adjusted odds ratio (AOR) 3.92, 95% CI 1– 15.35, P = 0.049; multiple cavities: AOR 4.1, 95% CI 1.26– 13.31, P = 0.019; thick-walled cavity: AOR 2.89, 95% CI 1.05– 8.03, P = 0.041. In quartile of TyG index, compared with patients in quartile 1, the AOR (95% CI) values for air bronchial sign in quartile 4 was 8.1 (1.7– 44), p = 0.011; multiple cavities was 7.1 (1.7– 32), p = 0.008; thick-walled cavity was 7.8 (1.9– 34.7), p = 0.005.Conclusion: The present study showed that an increased TyG index was positively related to the severity of patients with T2DM-PTB.Keywords: CT features, insulin resistance, triglyceride glucose index, pulmonary tuberculosis, T2DM |
| first_indexed | 2024-12-20T07:15:32Z |
| format | Article |
| id | doaj.art-253b6febbcc1412b81ae2241c9ea83c7 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-20T07:15:32Z |
| publishDate | 2022-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-253b6febbcc1412b81ae2241c9ea83c72022-12-21T19:48:48ZengDove Medical PressInfection and Drug Resistance1178-69732022-01-01Volume 1511112572242Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes MellitusChen YPeng AChen YKong XLi LTang GLi HChen YJiang FLi PZhang QYong Chen,1,* Anzhou Peng,2,* Yiqing Chen,1 Xianghua Kong,2 Linyang Li,2 Guangxiao Tang,3 Huifen Li,2 Yu Chen,4 Fan Jiang,2 Peibo Li,5 Qiu Zhang1 1Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, People’s Republic of China; 2Department of the Fifth Tuberculosis, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 3Department of Radiology, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 4Department of Medical Record Statistics Room, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China; 5Department of Physician Assistant, Chongqing Public Health Medical Center, Chongqing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qiu Zhang; Peibo Li Tel +8613965015060; +8618709843713Email zhangqiu@ahmu.edu.cn; lipeibo013@163.comBackground: The purpose of this study was to investigate the association of the triglyceride glucose (TyG) index, a surrogate marker of insulin resistance (IR) with a high sensitivity of 96.5% and a specificity of 85.0% for the diagnosis of IR, with computed tomography (CT) features in patients with tuberculosis and diabetes mellitus.Methods: A total of 247 subjects were enrolled from July, 2020 to May, 2021. The basic clinical features and CT features were analyzed. In addition, multivariate logistic regression analysis models were employed to evaluate the association of the TyG indicator with CT features in participants.Results: In the quartile groups of TyG index, air bronchial sign detection rate was 11.7%, 14.5%, 23.2%, and 44.1%; large segmented leafy shadow detection rate was 27.9%, 40.6%, 46.4%, and 66.2%; thick-walled cavity was found in 38.2%, 43.4%, 57.9%, and 69.1%; the rate of multiple cavities was 17.6%, 27.5%, 36.2%, 52.9%; the rate of lymph node enlargement was 22.1%, 17.4%, 28.9%, and 38.2%, respectively. In addition, the positive relation with the TyG index and the prevalence of abnormal CT signs was observed in the fully adjusted model: TyG, per one-unit increase: air bronchial sign: adjusted odds ratio (AOR) 3.92, 95% CI 1– 15.35, P = 0.049; multiple cavities: AOR 4.1, 95% CI 1.26– 13.31, P = 0.019; thick-walled cavity: AOR 2.89, 95% CI 1.05– 8.03, P = 0.041. In quartile of TyG index, compared with patients in quartile 1, the AOR (95% CI) values for air bronchial sign in quartile 4 was 8.1 (1.7– 44), p = 0.011; multiple cavities was 7.1 (1.7– 32), p = 0.008; thick-walled cavity was 7.8 (1.9– 34.7), p = 0.005.Conclusion: The present study showed that an increased TyG index was positively related to the severity of patients with T2DM-PTB.Keywords: CT features, insulin resistance, triglyceride glucose index, pulmonary tuberculosis, T2DMhttps://www.dovepress.com/association-of-tyg-index-with-ct-features-in-patients-with-tuberculosi-peer-reviewed-fulltext-article-IDRct featuresinsulin resistancetriglyceride glucose indexpulmonary tuberculosist2dm |
| spellingShingle | Chen Y Peng A Chen Y Kong X Li L Tang G Li H Chen Y Jiang F Li P Zhang Q Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus Infection and Drug Resistance ct features insulin resistance triglyceride glucose index pulmonary tuberculosis t2dm |
| title | Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus |
| title_full | Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus |
| title_fullStr | Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus |
| title_full_unstemmed | Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus |
| title_short | Association of TyG Index with CT Features in Patients with Tuberculosis and Diabetes Mellitus |
| title_sort | association of tyg index with ct features in patients with tuberculosis and diabetes mellitus |
| topic | ct features insulin resistance triglyceride glucose index pulmonary tuberculosis t2dm |
| url | https://www.dovepress.com/association-of-tyg-index-with-ct-features-in-patients-with-tuberculosi-peer-reviewed-fulltext-article-IDR |
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