Unique features of dyslipidemia in women across a lifetime and a tailored approach to management
Purpose of Review: Cardiovascular disease is a leading cause of death worldwide. Dyslipidemia is a critical modifiable risk factor for the prevention of cardiovascular disease. Dyslipidemia affects a large population of women and is especially pervasive within racial/ethnic minorities. Recent Findin...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-06-01
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| Series: | American Journal of Preventive Cardiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666667724000345 |
| _version_ | 1797214803010256896 |
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| author | Neeja Patel Nikita Mittal Michael J. Wilkinson Pam R. Taub |
| author_facet | Neeja Patel Nikita Mittal Michael J. Wilkinson Pam R. Taub |
| author_sort | Neeja Patel |
| collection | DOAJ |
| description | Purpose of Review: Cardiovascular disease is a leading cause of death worldwide. Dyslipidemia is a critical modifiable risk factor for the prevention of cardiovascular disease. Dyslipidemia affects a large population of women and is especially pervasive within racial/ethnic minorities. Recent Findings: Dyslipidemia in pregnancy leads to worse outcomes for patients and creates increased cardiovascular risk for women at an older age. However, women remain underscreened and undertreated compared to men. Females also comprise a small portion of clinical trial participants for lipid lowering agents with increased disease prevalence compared to trial representation. However, recent lipid trials have shown different efficacies of therapies such as ezetimibe, inclisiran, and bempedoic acid with a greater relative benefit for women. Summary: Pathophysiology of dyslipidemia varies between men and women and across a woman's lifetime. While increased lipid levels or lipid imbalances are more common in postmenopausal women over age 50, conditions such as PCOS and FH produce higher cardiovascular risk for young women.Best practices for management of women with dyslipidemia include early screening with lifestyle intervention and pharmacotherapy with statin and non-statin agents to achieve guideline directed LDL-C thresholds. |
| first_indexed | 2024-04-24T11:19:58Z |
| format | Article |
| id | doaj.art-253c6afb92cc48339ade20295aa4cd68 |
| institution | Directory Open Access Journal |
| issn | 2666-6677 |
| language | English |
| last_indexed | 2024-04-24T11:19:58Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Preventive Cardiology |
| spelling | doaj.art-253c6afb92cc48339ade20295aa4cd682024-04-11T04:42:00ZengElsevierAmerican Journal of Preventive Cardiology2666-66772024-06-0118100666Unique features of dyslipidemia in women across a lifetime and a tailored approach to managementNeeja Patel0Nikita Mittal1Michael J. Wilkinson2Pam R. Taub3University of California, Los Angeles, United StatesUniversity of California, San Diego, United StatesUniversity of California, San Diego, United StatesUniversity of California, San Diego, United States; Corresponding author at: 9300 Campus Point Drive, La Jolla, CA 92037.Purpose of Review: Cardiovascular disease is a leading cause of death worldwide. Dyslipidemia is a critical modifiable risk factor for the prevention of cardiovascular disease. Dyslipidemia affects a large population of women and is especially pervasive within racial/ethnic minorities. Recent Findings: Dyslipidemia in pregnancy leads to worse outcomes for patients and creates increased cardiovascular risk for women at an older age. However, women remain underscreened and undertreated compared to men. Females also comprise a small portion of clinical trial participants for lipid lowering agents with increased disease prevalence compared to trial representation. However, recent lipid trials have shown different efficacies of therapies such as ezetimibe, inclisiran, and bempedoic acid with a greater relative benefit for women. Summary: Pathophysiology of dyslipidemia varies between men and women and across a woman's lifetime. While increased lipid levels or lipid imbalances are more common in postmenopausal women over age 50, conditions such as PCOS and FH produce higher cardiovascular risk for young women.Best practices for management of women with dyslipidemia include early screening with lifestyle intervention and pharmacotherapy with statin and non-statin agents to achieve guideline directed LDL-C thresholds.http://www.sciencedirect.com/science/article/pii/S2666667724000345DyslipidemiaCardiovascular diseasePreventionLipoprotein(a), Menopause, Bempedoic acid |
| spellingShingle | Neeja Patel Nikita Mittal Michael J. Wilkinson Pam R. Taub Unique features of dyslipidemia in women across a lifetime and a tailored approach to management American Journal of Preventive Cardiology Dyslipidemia Cardiovascular disease Prevention Lipoprotein(a), Menopause, Bempedoic acid |
| title | Unique features of dyslipidemia in women across a lifetime and a tailored approach to management |
| title_full | Unique features of dyslipidemia in women across a lifetime and a tailored approach to management |
| title_fullStr | Unique features of dyslipidemia in women across a lifetime and a tailored approach to management |
| title_full_unstemmed | Unique features of dyslipidemia in women across a lifetime and a tailored approach to management |
| title_short | Unique features of dyslipidemia in women across a lifetime and a tailored approach to management |
| title_sort | unique features of dyslipidemia in women across a lifetime and a tailored approach to management |
| topic | Dyslipidemia Cardiovascular disease Prevention Lipoprotein(a), Menopause, Bempedoic acid |
| url | http://www.sciencedirect.com/science/article/pii/S2666667724000345 |
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