Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

Pathogen invasion-dependent tissue reservoirs and plasmid-encoded antibiotic degradation boost plasmid spread in the gut

Many plasmids encode antibiotic resistance genes. Through conjugation, plasmids can be rapidly disseminated. Previous work identified gut luminal donor/recipient blooms and tissue-lodged plasmid-bearing persister cells of the enteric pathogen Salmonella enterica serovar Typhimurium (S.Tm) that survi...

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Bibliographic Details
Main Authors: Erik Bakkeren, Joana Anuschka Herter, Jana Sanne Huisman, Yves Steiger, Ersin Gül, Joshua Patrick Mark Newson, Alexander Oliver Brachmann, Jörn Piel, Roland Regoes, Sebastian Bonhoeffer, Médéric Diard, Wolf-Dietrich Hardt
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
plasmids
Salmonella
antibiotic resistance
tissue reservoirs
persistence
Online Access:https://elifesciences.org/articles/69744

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