Spatial Layouts of Low‐Entropy Hydration Shells Guide Protein Binding

Spatial Layouts of Low‐Entropy Hydration Shells Guide Protein Binding

Abstract Protein–protein binding enables orderly biological self‐organization and is therefore considered a miracle of nature. Protein‒protein binding is driven by electrostatic forces, hydrogen bonding, van der Waals force, and hydrophobic interactions. Among these physical forces, only hydrophobic...

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Bibliographic Details
Main Authors: Lin Yang, Shuai Guo, Chenchen Liao, Chengyu Hou, Shenda Jiang, Jiacheng Li, Xiaoliang Ma, Liping Shi, Lin Ye, Xiaodong He
Format: Article
Language:English
Published: Wiley 2023-07-01
Series:Global Challenges
Subjects:
binding site
Gibbs free energy
hydration shell
low entropy
protein–protein interactions
Online Access:https://doi.org/10.1002/gch2.202300022

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