Resistance to Antimalarial Monotherapy Is Cyclic
Malaria is a prevalent parasitic disease that is estimated to kill between one and two million people—mostly children—every year. Here, we query PubMed for malaria drug resistance and plot the yearly citations of 14 common antimalarials. Remarkably, most antimalarial drugs display cyclic resistance...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/3/781 |
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| author | Rachel Weitzman Ortal Calfon-Peretz Trishna Saha Naamah Bloch Karin Ben Zaken Avi Rosenfeld Moshe Amitay Abraham O. Samson |
| author_facet | Rachel Weitzman Ortal Calfon-Peretz Trishna Saha Naamah Bloch Karin Ben Zaken Avi Rosenfeld Moshe Amitay Abraham O. Samson |
| author_sort | Rachel Weitzman |
| collection | DOAJ |
| description | Malaria is a prevalent parasitic disease that is estimated to kill between one and two million people—mostly children—every year. Here, we query PubMed for malaria drug resistance and plot the yearly citations of 14 common antimalarials. Remarkably, most antimalarial drugs display cyclic resistance patterns, rising and falling over four decades. The antimalarial drugs that exhibit cyclic resistance are quinine, chloroquine, mefloquine, amodiaquine, artesunate, artemether, sulfadoxine, doxycycline, halofantrine, piperaquine, pyrimethamine, atovaquone, artemisinin, and dihydroartemisinin. Exceptionally, the resistance of the two latter drugs can also correlate with a linear rise. Our predicted antimalarial drug resistance is consistent with clinical data reported by the Worldwide Antimalarial Resistance Network (WWARN) and validates our methodology. Notably, the cyclical resistance suggests that most antimalarial drugs are sustainable in the end. Furthermore, cyclic resistance is clinically relevant and discourages routine monotherapy, in particular, while resistance is on the rise. Finally, cyclic resistance encourages the combination of antimalarial drugs at distinct phases of resistance. |
| first_indexed | 2024-03-09T23:39:40Z |
| format | Article |
| id | doaj.art-2541cf71d827435a831b7b1a7413bb95 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:39:40Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2541cf71d827435a831b7b1a7413bb952023-11-23T16:53:53ZengMDPI AGJournal of Clinical Medicine2077-03832022-01-0111378110.3390/jcm11030781Resistance to Antimalarial Monotherapy Is CyclicRachel Weitzman0Ortal Calfon-Peretz1Trishna Saha2Naamah Bloch3Karin Ben Zaken4Avi Rosenfeld5Moshe Amitay6Abraham O. Samson7Bioinformatic Department, Jerusalem College of Technology, Jerusalem 9372115, IsraelBioinformatic Department, Jerusalem College of Technology, Jerusalem 9372115, IsraelDrug Discovery Lab, Azrieli Faculty of Medicine, Bar Ilan University, Safed 1311502, IsraelDrug Discovery Lab, Azrieli Faculty of Medicine, Bar Ilan University, Safed 1311502, IsraelDrug Discovery Lab, Azrieli Faculty of Medicine, Bar Ilan University, Safed 1311502, IsraelDepartment of Computer Science, Jerusalem College of Technology, Jerusalem 9372115, IsraelBioinformatic Department, Jerusalem College of Technology, Jerusalem 9372115, IsraelDrug Discovery Lab, Azrieli Faculty of Medicine, Bar Ilan University, Safed 1311502, IsraelMalaria is a prevalent parasitic disease that is estimated to kill between one and two million people—mostly children—every year. Here, we query PubMed for malaria drug resistance and plot the yearly citations of 14 common antimalarials. Remarkably, most antimalarial drugs display cyclic resistance patterns, rising and falling over four decades. The antimalarial drugs that exhibit cyclic resistance are quinine, chloroquine, mefloquine, amodiaquine, artesunate, artemether, sulfadoxine, doxycycline, halofantrine, piperaquine, pyrimethamine, atovaquone, artemisinin, and dihydroartemisinin. Exceptionally, the resistance of the two latter drugs can also correlate with a linear rise. Our predicted antimalarial drug resistance is consistent with clinical data reported by the Worldwide Antimalarial Resistance Network (WWARN) and validates our methodology. Notably, the cyclical resistance suggests that most antimalarial drugs are sustainable in the end. Furthermore, cyclic resistance is clinically relevant and discourages routine monotherapy, in particular, while resistance is on the rise. Finally, cyclic resistance encourages the combination of antimalarial drugs at distinct phases of resistance.https://www.mdpi.com/2077-0383/11/3/781malariadrug resistanceantimalarial resistancetext-miningparasitologyhealth policy |
| spellingShingle | Rachel Weitzman Ortal Calfon-Peretz Trishna Saha Naamah Bloch Karin Ben Zaken Avi Rosenfeld Moshe Amitay Abraham O. Samson Resistance to Antimalarial Monotherapy Is Cyclic Journal of Clinical Medicine malaria drug resistance antimalarial resistance text-mining parasitology health policy |
| title | Resistance to Antimalarial Monotherapy Is Cyclic |
| title_full | Resistance to Antimalarial Monotherapy Is Cyclic |
| title_fullStr | Resistance to Antimalarial Monotherapy Is Cyclic |
| title_full_unstemmed | Resistance to Antimalarial Monotherapy Is Cyclic |
| title_short | Resistance to Antimalarial Monotherapy Is Cyclic |
| title_sort | resistance to antimalarial monotherapy is cyclic |
| topic | malaria drug resistance antimalarial resistance text-mining parasitology health policy |
| url | https://www.mdpi.com/2077-0383/11/3/781 |
| work_keys_str_mv | AT rachelweitzman resistancetoantimalarialmonotherapyiscyclic AT ortalcalfonperetz resistancetoantimalarialmonotherapyiscyclic AT trishnasaha resistancetoantimalarialmonotherapyiscyclic AT naamahbloch resistancetoantimalarialmonotherapyiscyclic AT karinbenzaken resistancetoantimalarialmonotherapyiscyclic AT avirosenfeld resistancetoantimalarialmonotherapyiscyclic AT mosheamitay resistancetoantimalarialmonotherapyiscyclic AT abrahamosamson resistancetoantimalarialmonotherapyiscyclic |