Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China
Aim. To compare the clinical characteristics of survival and nonsurvival patients with severe acute pancreatitis (SAP) and explore the risk of mortality in SAP patients. Methods. This was a single-center retrospective study performed in a severe acute pancreatitis diagnosis and treatment center. Acc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2024-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2024/8236616 |
| _version_ | 1827010042512015360 |
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| author | Jun Li Jingyan Gao Min Huang Xiaoyun Fu Bao Fu |
| author_facet | Jun Li Jingyan Gao Min Huang Xiaoyun Fu Bao Fu |
| author_sort | Jun Li |
| collection | DOAJ |
| description | Aim. To compare the clinical characteristics of survival and nonsurvival patients with severe acute pancreatitis (SAP) and explore the risk of mortality in SAP patients. Methods. This was a single-center retrospective study performed in a severe acute pancreatitis diagnosis and treatment center. According to the outcome, SAP patients were divided into survival group and nonsurvival group. One-way ANOVA or independent t-test was used to compare the clinical characteristics of two groups of patients. Multivariate retrospective analysis was used to identify risk factors for mortality in SAP patients. Results. A total of 486 SAP patients were included in the study, and the 90-day mortality for SAP patients was 13.58%. The common etiologies of SAP are biliary tract diseases (69.75%) and hyperlipidemia (17.28%). The most common complications caused by SAP were organ failure (55.14%), ARDS (50.62%), AKI (30.45%), sepsis (27.16%), and abdominal fluid collection (27.57%). There were differences in age, complications, and medical intervention between the nonsurvival group and the survival group. The main causes of death were infection (46.97%), abdominal bleeding (28.79%), and organ failure (9.09%). The binary logistic regression analysis showed that there were significant differences in age, AKI, sepsis, abdominal hemorrhage, organ failure, laparotomy, creatinine, and APTT between the nonsurvival group and the survival group. Conclusion. Age, AKI, sepsis, abdominal hemorrhage, and organ failure are risk factors for mortality in SAP patients. SAP patients with high creatinine and prolonged APTT upon admission require doctors to be vigilant. The main cause of death in SAP patients is pancreatitis-related organ failure and secondary infection. |
| first_indexed | 2024-04-24T11:59:28Z |
| format | Article |
| id | doaj.art-2543307b684240fea371c30568342e10 |
| institution | Directory Open Access Journal |
| issn | 1687-630X |
| language | English |
| last_indexed | 2025-02-18T12:58:54Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj.art-2543307b684240fea371c30568342e102024-11-02T03:56:27ZengHindawi LimitedGastroenterology Research and Practice1687-630X2024-01-01202410.1155/2024/8236616Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, ChinaJun Li0Jingyan Gao1Min Huang2Xiaoyun Fu3Bao Fu4Department of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineDepartment of Critical Care MedicineAim. To compare the clinical characteristics of survival and nonsurvival patients with severe acute pancreatitis (SAP) and explore the risk of mortality in SAP patients. Methods. This was a single-center retrospective study performed in a severe acute pancreatitis diagnosis and treatment center. According to the outcome, SAP patients were divided into survival group and nonsurvival group. One-way ANOVA or independent t-test was used to compare the clinical characteristics of two groups of patients. Multivariate retrospective analysis was used to identify risk factors for mortality in SAP patients. Results. A total of 486 SAP patients were included in the study, and the 90-day mortality for SAP patients was 13.58%. The common etiologies of SAP are biliary tract diseases (69.75%) and hyperlipidemia (17.28%). The most common complications caused by SAP were organ failure (55.14%), ARDS (50.62%), AKI (30.45%), sepsis (27.16%), and abdominal fluid collection (27.57%). There were differences in age, complications, and medical intervention between the nonsurvival group and the survival group. The main causes of death were infection (46.97%), abdominal bleeding (28.79%), and organ failure (9.09%). The binary logistic regression analysis showed that there were significant differences in age, AKI, sepsis, abdominal hemorrhage, organ failure, laparotomy, creatinine, and APTT between the nonsurvival group and the survival group. Conclusion. Age, AKI, sepsis, abdominal hemorrhage, and organ failure are risk factors for mortality in SAP patients. SAP patients with high creatinine and prolonged APTT upon admission require doctors to be vigilant. The main cause of death in SAP patients is pancreatitis-related organ failure and secondary infection.http://dx.doi.org/10.1155/2024/8236616 |
| spellingShingle | Jun Li Jingyan Gao Min Huang Xiaoyun Fu Bao Fu Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China Gastroenterology Research and Practice |
| title | Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China |
| title_full | Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China |
| title_fullStr | Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China |
| title_full_unstemmed | Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China |
| title_short | Risk Factors for Death in Patients with Severe Acute Pancreatitis in Guizhou Province, China |
| title_sort | risk factors for death in patients with severe acute pancreatitis in guizhou province china |
| url | http://dx.doi.org/10.1155/2024/8236616 |
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