UHPLC-MS/MS Assay for Quantification of Legubicin, a Novel Doxorubicin-Based Legumain-Activated Prodrug, and Its Application to Pharmacokinetic and Tissue Distribution Studies

UHPLC-MS/MS Assay for Quantification of Legubicin, a Novel Doxorubicin-Based Legumain-Activated Prodrug, and Its Application to Pharmacokinetic and Tissue Distribution Studies

Legubicin, a novel prodrug based on doxorubicin, has both albumin-binding and legumain-activating properties. The aim of this study was to develop and validate a UHPLC-MS/MS method for investigating the in vivo pharmacokinetics and tissue distribution profiles of legubicin in rats and tumor-bearing...

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Bibliographic Details
Main Authors:	Liyuan Ma, Qiaoling Yu, Meng Zhuang, Chen Yang, Yuan Liu, Yuling Li, Cheng Liu, Xiaoyan Shen, Yan Chang
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	Molecules
Subjects:	doxorubicin Leu-DOX legumain prodrug UHPLC-MS/MS pharmacokinetics
Online Access:	https://www.mdpi.com/1420-3049/29/4/775

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