Research progress of microRNAs suppressing tumorigenesis through Hippo signaling
The aberrant activation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), downstream effectors of the Hippo signaling pathway, has been implicated in hepatocellular carcinoma(HCC). The microRNAs (miRNAs) works as a tumor suppressors that influence the prol...
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| Format: | Article |
| Language: | zho |
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Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2023-12-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-12-1871.pdf |
| _version_ | 1827391318340403200 |
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| author | CHA Na, HAO Dandan, LI Tianzhu |
| author_facet | CHA Na, HAO Dandan, LI Tianzhu |
| author_sort | CHA Na, HAO Dandan, LI Tianzhu |
| collection | DOAJ |
| description | The aberrant activation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), downstream effectors of the Hippo signaling pathway, has been implicated in hepatocellular carcinoma(HCC). The microRNAs (miRNAs) works as a tumor suppressors that influence the proliferation, migration and apoptosis of tumor cells by modulating Hippo-YAP/TAZ signaling during hepatic tumorigenesis. Exploring the role of miRNAs in regulating Hippo YAP/TAZ pathway in HCC can provide new ideas for the diagnosis and treatment of HCC. |
| first_indexed | 2024-03-08T17:08:35Z |
| format | Article |
| id | doaj.art-2543f30b27bf4c41978c16f2d596731e |
| institution | Directory Open Access Journal |
| issn | 1001-6325 |
| language | zho |
| last_indexed | 2024-03-08T17:08:35Z |
| publishDate | 2023-12-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj.art-2543f30b27bf4c41978c16f2d596731e2024-01-04T01:10:35ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252023-12-0143121871187510.16352/j.issn.1001-6325.2023.12.1871Research progress of microRNAs suppressing tumorigenesis through Hippo signalingCHA Na, HAO Dandan, LI Tianzhu01. Department of Oncology, the Affiliated Hospital of Chifeng University, Chifeng 024000;;2. Department of Physiology;;3. Molecular Medicine Research Center, School of Basic Medical Science, Chifeng University, Chifeng 024000, ChinaThe aberrant activation of yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), downstream effectors of the Hippo signaling pathway, has been implicated in hepatocellular carcinoma(HCC). The microRNAs (miRNAs) works as a tumor suppressors that influence the proliferation, migration and apoptosis of tumor cells by modulating Hippo-YAP/TAZ signaling during hepatic tumorigenesis. Exploring the role of miRNAs in regulating Hippo YAP/TAZ pathway in HCC can provide new ideas for the diagnosis and treatment of HCC.http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-12-1871.pdfhepatocellular carcinoma|hippo pathway|micrornas|molecular mechanism |
| spellingShingle | CHA Na, HAO Dandan, LI Tianzhu Research progress of microRNAs suppressing tumorigenesis through Hippo signaling Jichu yixue yu linchuang hepatocellular carcinoma|hippo pathway|micrornas|molecular mechanism |
| title | Research progress of microRNAs suppressing tumorigenesis through Hippo signaling |
| title_full | Research progress of microRNAs suppressing tumorigenesis through Hippo signaling |
| title_fullStr | Research progress of microRNAs suppressing tumorigenesis through Hippo signaling |
| title_full_unstemmed | Research progress of microRNAs suppressing tumorigenesis through Hippo signaling |
| title_short | Research progress of microRNAs suppressing tumorigenesis through Hippo signaling |
| title_sort | research progress of micrornas suppressing tumorigenesis through hippo signaling |
| topic | hepatocellular carcinoma|hippo pathway|micrornas|molecular mechanism |
| url | http://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2023-43-12-1871.pdf |
| work_keys_str_mv | AT chanahaodandanlitianzhu researchprogressofmicrornassuppressingtumorigenesisthroughhipposignaling |