Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China.
Here, we report the genetic diversity of HIV-1 and emergence of novel HIV-1 unique recombinant forms (URF) in both HIV-infected intravenous drug users (IDU) and men who have sex with men (MSM) in Guangzhou, China. We further characterized a novel URF strain isolated from an HIV-infected MSM, GD698....
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5389846?pdf=render |
| _version_ | 1818946167605559296 |
|---|---|
| author | Yue Wu Xuqi Ren Dan Yin Haiying Wang Zhengwei Wan Xiufen Li Guifang Hu Shixing Tang |
| author_facet | Yue Wu Xuqi Ren Dan Yin Haiying Wang Zhengwei Wan Xiufen Li Guifang Hu Shixing Tang |
| author_sort | Yue Wu |
| collection | DOAJ |
| description | Here, we report the genetic diversity of HIV-1 and emergence of novel HIV-1 unique recombinant forms (URF) in both HIV-infected intravenous drug users (IDU) and men who have sex with men (MSM) in Guangzhou, China. We further characterized a novel URF strain isolated from an HIV-infected MSM, GD698. Near full-length genome (NFLG) phylogenic analysis showed that this novel URF was composed of CRF07_BC and CRF55_01B, with two recombinant breakpoints (nt 6,003 and 8,251 relative to the HXB2 genome) in the vpu/env and env genes, respectively. Twenty six percent of the genome is classified as CRF55_01B, spanning part of vpu and most of the env gene. The remaining 74% of the genome is classified as CRF07_BC. Both the backbone CRF07_BC sequence and CRF55_01B fragment were clustered with the HIV-1 isolates found in MSM. The emergence of the novel HIV-1 recombinant indicates the ongoing recombinants derived from the CRF07_BC and CRF55_01B isolates, and provides critical insights into our understanding of the dynamics and complexity of the HIV-1 epidemic in China. |
| first_indexed | 2024-12-20T08:10:42Z |
| format | Article |
| id | doaj.art-2543fb819cbd44fc905cf24bb1b0b082 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T08:10:42Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2543fb819cbd44fc905cf24bb1b0b0822022-12-21T19:47:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017577010.1371/journal.pone.0175770Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China.Yue WuXuqi RenDan YinHaiying WangZhengwei WanXiufen LiGuifang HuShixing TangHere, we report the genetic diversity of HIV-1 and emergence of novel HIV-1 unique recombinant forms (URF) in both HIV-infected intravenous drug users (IDU) and men who have sex with men (MSM) in Guangzhou, China. We further characterized a novel URF strain isolated from an HIV-infected MSM, GD698. Near full-length genome (NFLG) phylogenic analysis showed that this novel URF was composed of CRF07_BC and CRF55_01B, with two recombinant breakpoints (nt 6,003 and 8,251 relative to the HXB2 genome) in the vpu/env and env genes, respectively. Twenty six percent of the genome is classified as CRF55_01B, spanning part of vpu and most of the env gene. The remaining 74% of the genome is classified as CRF07_BC. Both the backbone CRF07_BC sequence and CRF55_01B fragment were clustered with the HIV-1 isolates found in MSM. The emergence of the novel HIV-1 recombinant indicates the ongoing recombinants derived from the CRF07_BC and CRF55_01B isolates, and provides critical insights into our understanding of the dynamics and complexity of the HIV-1 epidemic in China.http://europepmc.org/articles/PMC5389846?pdf=render |
| spellingShingle | Yue Wu Xuqi Ren Dan Yin Haiying Wang Zhengwei Wan Xiufen Li Guifang Hu Shixing Tang Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. PLoS ONE |
| title | Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. |
| title_full | Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. |
| title_fullStr | Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. |
| title_full_unstemmed | Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. |
| title_short | Characterization of a novel HIV-1 unique recombinant form between CRF07_BC and CRF55_01B in men who have sex with men in Guangzhou, China. |
| title_sort | characterization of a novel hiv 1 unique recombinant form between crf07 bc and crf55 01b in men who have sex with men in guangzhou china |
| url | http://europepmc.org/articles/PMC5389846?pdf=render |
| work_keys_str_mv | AT yuewu characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina AT xuqiren characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina AT danyin characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina AT haiyingwang characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina AT zhengweiwan characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina AT xiufenli characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina AT guifanghu characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina AT shixingtang characterizationofanovelhiv1uniquerecombinantformbetweencrf07bcandcrf5501binmenwhohavesexwithmeninguangzhouchina |