Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis
PURPOSE:We aimed to evaluate whether histogram analysis of susceptibility-weighted imaging (SWI) could quantify liver fibrosis grade in patients with chronic liver disease (CLD).METHODS:Fifty-three patients with CLD who underwent multi-echo SWI (TEs of 2.5, 5, and 10 ms) were included. Histogram ana...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2016-07-01
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| Series: | Diagnostic and Interventional Radiology |
| Online Access: |
http://www.dirjournal.org/archives/archive-detail/article-preview/feasibility-of-histogram-analysis-of-susceptibilit/55445
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| _version_ | 1797691196998418432 |
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| author | Zhao-Xia Yang He-Yue Liang Xin-Xing Hu Ya-Qin Huang Ying Ding Shan Yang Meng-Su Zeng Sheng-Xiang Rao |
| author_facet | Zhao-Xia Yang He-Yue Liang Xin-Xing Hu Ya-Qin Huang Ying Ding Shan Yang Meng-Su Zeng Sheng-Xiang Rao |
| author_sort | Zhao-Xia Yang |
| collection | DOAJ |
| description | PURPOSE:We aimed to evaluate whether histogram analysis of susceptibility-weighted imaging (SWI) could quantify liver fibrosis grade in patients with chronic liver disease (CLD).METHODS:Fifty-three patients with CLD who underwent multi-echo SWI (TEs of 2.5, 5, and 10 ms) were included. Histogram analysis of SWI images were performed and mean, variance, skewness, kurtosis, and the 1st, 10th, 50th, 90th, and 99th percentiles were derived. Quantitative histogram parameters were compared. For significant parameters, further receiver operating characteristic (ROC) analyses were performed to evaluate the potential diagnostic performance for differentiating liver fibrosis stages.RESULTS:The number of patients in each pathologic fibrosis grade was 7, 3, 5, 5, and 33 for F0, F1, F2, F3, and F4, respectively. The results of variance (TE: 10 ms), 90th percentile (TE: 10 ms), and 99th percentile (TE: 10 and 5 ms) in F0–F3 group were significantly lower than in F4 group, with areas under the ROC curves (AUCs) of 0.84 for variance and 0.70–0.73 for the 90th and 99th percentiles, respectively. The results of variance (TE: 10 and 5 ms), 99th percentile (TE: 10 ms), and skewness (TE: 2.5 and 5 ms) in F0–F2 group were smaller than those of F3/F4 group, with AUCs of 0.88 and 0.69 for variance (TE: 10 and 5 ms, respectively), 0.68 for 99th percentile (TE: 10 ms), and 0.73 and 0.68 for skewness (TE: 2.5 and 5 ms, respectively).CONCLUSION:Magnetic resonance histogram analysis of SWI, particularly the variance, is promising for predicting advanced liver fibrosis and cirrhosis. |
| first_indexed | 2024-03-12T02:09:52Z |
| format | Article |
| id | doaj.art-2544101e8cc946028ccf08e2453c12e8 |
| institution | Directory Open Access Journal |
| issn | 1305-3825 1305-3612 |
| language | English |
| last_indexed | 2024-03-12T02:09:52Z |
| publishDate | 2016-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Diagnostic and Interventional Radiology |
| spelling | doaj.art-2544101e8cc946028ccf08e2453c12e82023-09-06T13:41:52ZengGalenos Publishing HouseDiagnostic and Interventional Radiology1305-38251305-36122016-07-0122430130710.5152/dir.2016.1528413049054Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosisZhao-Xia Yang0He-Yue Liang1Xin-Xing Hu2Ya-Qin Huang3Ying Ding4Shan Yang5Meng-Su Zeng6Sheng-Xiang Rao7 Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China Department of Radiology, Zhongshan Hospital of Fudan University and Shanghai Institute of Medical Imaging, Shanghai, China PURPOSE:We aimed to evaluate whether histogram analysis of susceptibility-weighted imaging (SWI) could quantify liver fibrosis grade in patients with chronic liver disease (CLD).METHODS:Fifty-three patients with CLD who underwent multi-echo SWI (TEs of 2.5, 5, and 10 ms) were included. Histogram analysis of SWI images were performed and mean, variance, skewness, kurtosis, and the 1st, 10th, 50th, 90th, and 99th percentiles were derived. Quantitative histogram parameters were compared. For significant parameters, further receiver operating characteristic (ROC) analyses were performed to evaluate the potential diagnostic performance for differentiating liver fibrosis stages.RESULTS:The number of patients in each pathologic fibrosis grade was 7, 3, 5, 5, and 33 for F0, F1, F2, F3, and F4, respectively. The results of variance (TE: 10 ms), 90th percentile (TE: 10 ms), and 99th percentile (TE: 10 and 5 ms) in F0–F3 group were significantly lower than in F4 group, with areas under the ROC curves (AUCs) of 0.84 for variance and 0.70–0.73 for the 90th and 99th percentiles, respectively. The results of variance (TE: 10 and 5 ms), 99th percentile (TE: 10 ms), and skewness (TE: 2.5 and 5 ms) in F0–F2 group were smaller than those of F3/F4 group, with AUCs of 0.88 and 0.69 for variance (TE: 10 and 5 ms, respectively), 0.68 for 99th percentile (TE: 10 ms), and 0.73 and 0.68 for skewness (TE: 2.5 and 5 ms, respectively).CONCLUSION:Magnetic resonance histogram analysis of SWI, particularly the variance, is promising for predicting advanced liver fibrosis and cirrhosis. http://www.dirjournal.org/archives/archive-detail/article-preview/feasibility-of-histogram-analysis-of-susceptibilit/55445 |
| spellingShingle | Zhao-Xia Yang He-Yue Liang Xin-Xing Hu Ya-Qin Huang Ying Ding Shan Yang Meng-Su Zeng Sheng-Xiang Rao Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis Diagnostic and Interventional Radiology |
| title | Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis |
| title_full | Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis |
| title_fullStr | Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis |
| title_full_unstemmed | Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis |
| title_short | Feasibility of histogram analysis of susceptibility-weighted MRI for staging of liver fibrosis |
| title_sort | feasibility of histogram analysis of susceptibility weighted mri for staging of liver fibrosis |
| url |
http://www.dirjournal.org/archives/archive-detail/article-preview/feasibility-of-histogram-analysis-of-susceptibilit/55445
|
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