Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics
Abstract Background Making the distinction between primary mucinous and metastatic ovarian tumors is often difficult, especially in tumors with a primary source from the gastrointestinal tract, pancreas and biliary tree. The aim of the following paper is to provide an overview of the problematics, w...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13000-021-01079-2 |
| _version_ | 1831526079960973312 |
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| author | Pavel Dundr Naveena Singh Barbora Nožičková Kristýna Němejcová Michaela Bártů Ivana Stružinská |
| author_facet | Pavel Dundr Naveena Singh Barbora Nožičková Kristýna Němejcová Michaela Bártů Ivana Stružinská |
| author_sort | Pavel Dundr |
| collection | DOAJ |
| description | Abstract Background Making the distinction between primary mucinous and metastatic ovarian tumors is often difficult, especially in tumors with a primary source from the gastrointestinal tract, pancreas and biliary tree. The aim of the following paper is to provide an overview of the problematics, with a focus on the possibilities of the differential diagnosis at the macroscopic, microscopic and immunohistochemical level. Main body The three main aspects of mucinous ovarian tumors are described in detail, including the comparison of the available diagnostic algorithms based on the evaluation of mostly macroscopic features, characterization of the spectrum of microscopic features, and a detailed analysis of the immunophenotype comparing 20 antibodies with the assessment of their statistical significance for differential diagnosis purposes. Specific features, including Krukenberg tumor and pseudomyxoma peritonei, are also discussed. Conclusion Despite the growing knowledge of the macroscopic and microscopic features of ovarian mucinous tumors and the availability of a wide range of immunohistochemical antibodies useful in this setting, there still remains a group of tumors which cannot be precisely classified without close clinical-pathological cooperation. |
| first_indexed | 2024-12-16T16:03:00Z |
| format | Article |
| id | doaj.art-254463afc26e4990b4c652024274c0fd |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-16T16:03:00Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-254463afc26e4990b4c652024274c0fd2022-12-21T22:25:26ZengBMCDiagnostic Pathology1746-15962021-03-0116111710.1186/s13000-021-01079-2Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematicsPavel Dundr0Naveena Singh1Barbora Nožičková2Kristýna Němejcová3Michaela Bártů4Ivana Stružinská5Institute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in PragueDepartment of Cellular Pathology, Barts Health NHS Trust, Queen Mary University of LondonInstitute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in PragueInstitute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in PragueInstitute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in PragueInstitute of Pathology, First Faculty of Medicine, Charles University and General University Hospital in PragueAbstract Background Making the distinction between primary mucinous and metastatic ovarian tumors is often difficult, especially in tumors with a primary source from the gastrointestinal tract, pancreas and biliary tree. The aim of the following paper is to provide an overview of the problematics, with a focus on the possibilities of the differential diagnosis at the macroscopic, microscopic and immunohistochemical level. Main body The three main aspects of mucinous ovarian tumors are described in detail, including the comparison of the available diagnostic algorithms based on the evaluation of mostly macroscopic features, characterization of the spectrum of microscopic features, and a detailed analysis of the immunophenotype comparing 20 antibodies with the assessment of their statistical significance for differential diagnosis purposes. Specific features, including Krukenberg tumor and pseudomyxoma peritonei, are also discussed. Conclusion Despite the growing knowledge of the macroscopic and microscopic features of ovarian mucinous tumors and the availability of a wide range of immunohistochemical antibodies useful in this setting, there still remains a group of tumors which cannot be precisely classified without close clinical-pathological cooperation.https://doi.org/10.1186/s13000-021-01079-2Ovarian tumorsMucinous carcinomaMucinous borderline tumorOvarian metastases |
| spellingShingle | Pavel Dundr Naveena Singh Barbora Nožičková Kristýna Němejcová Michaela Bártů Ivana Stružinská Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics Diagnostic Pathology Ovarian tumors Mucinous carcinoma Mucinous borderline tumor Ovarian metastases |
| title | Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics |
| title_full | Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics |
| title_fullStr | Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics |
| title_full_unstemmed | Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics |
| title_short | Primary mucinous ovarian tumors vs. ovarian metastases from gastrointestinal tract, pancreas and biliary tree: a review of current problematics |
| title_sort | primary mucinous ovarian tumors vs ovarian metastases from gastrointestinal tract pancreas and biliary tree a review of current problematics |
| topic | Ovarian tumors Mucinous carcinoma Mucinous borderline tumor Ovarian metastases |
| url | https://doi.org/10.1186/s13000-021-01079-2 |
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