The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study
OBJECTIVES This population-based, prospective cohort study investigated the association between glaucoma and mortality in older adults. METHODS Participants aged 45 years or older at baseline (47.9% male) were enrolled in 2011 for the China Health and Retirement Longitudinal Study (CHARLS). All-caus...
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| Format: | Article |
| Language: | English |
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Korean Society of Epidemiology
2023-07-01
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| Series: | Epidemiology and Health |
| Subjects: | |
| Online Access: | http://www.e-epih.org/upload/epih-45-e2023066.pdf |
| _version_ | 1797305280796557312 |
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| author | Xiaoxu Huang Mengqiao Xu Minwen Zhou Wenjia Liu Xiaohuan Zhao Xiaodong Sun |
| author_facet | Xiaoxu Huang Mengqiao Xu Minwen Zhou Wenjia Liu Xiaohuan Zhao Xiaodong Sun |
| author_sort | Xiaoxu Huang |
| collection | DOAJ |
| description | OBJECTIVES This population-based, prospective cohort study investigated the association between glaucoma and mortality in older adults. METHODS Participants aged 45 years or older at baseline (47.9% male) were enrolled in 2011 for the China Health and Retirement Longitudinal Study (CHARLS). All-cause mortality was observed during 7 years of follow-up. The baseline data were collected in the 2011 CHARLS, and participants were followed up for 7 years (until 2018). The risk of all-cause mortality was investigated using Cox proportional-hazards regression with age as the time scale, adjusting for significant risk factors and comorbid conditions. RESULTS Among the 14,803 participants included, the risk of all-cause death was significantly higher among people with glaucoma than among those without glaucoma, after adjustment for other confounders (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.04 to 2.03). In a subgroup analysis based on the mean age of death, among those who were 75 years and older (n=1,231), the risk of all-cause death was significantly higher in patients with glaucoma than in those without glaucoma (HR, 1.89; 95% CI, 1.24 to 1.89). CONCLUSIONS Participants with glaucoma had a higher risk of all-cause mortality, especially those aged 75 years and above. Our findings revealed potential mechanisms underlying an association between glaucoma and all-cause mortality. They also highlighted the importance of glaucoma management to prevent premature death in middle-aged and older adults. |
| first_indexed | 2024-03-08T00:23:36Z |
| format | Article |
| id | doaj.art-2546c140fa6048a381b231bb976247a7 |
| institution | Directory Open Access Journal |
| issn | 2092-7193 |
| language | English |
| last_indexed | 2024-03-08T00:23:36Z |
| publishDate | 2023-07-01 |
| publisher | Korean Society of Epidemiology |
| record_format | Article |
| series | Epidemiology and Health |
| spelling | doaj.art-2546c140fa6048a381b231bb976247a72024-02-16T01:04:25ZengKorean Society of EpidemiologyEpidemiology and Health2092-71932023-07-014510.4178/epih.e20230661428The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal StudyXiaoxu Huang0Mengqiao Xu1Minwen Zhou2Wenjia Liu3Xiaohuan Zhao4Xiaodong Sun5 Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Ophthalmology, Shanghai General Hospital (Shanghai First People’s Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaOBJECTIVES This population-based, prospective cohort study investigated the association between glaucoma and mortality in older adults. METHODS Participants aged 45 years or older at baseline (47.9% male) were enrolled in 2011 for the China Health and Retirement Longitudinal Study (CHARLS). All-cause mortality was observed during 7 years of follow-up. The baseline data were collected in the 2011 CHARLS, and participants were followed up for 7 years (until 2018). The risk of all-cause mortality was investigated using Cox proportional-hazards regression with age as the time scale, adjusting for significant risk factors and comorbid conditions. RESULTS Among the 14,803 participants included, the risk of all-cause death was significantly higher among people with glaucoma than among those without glaucoma, after adjustment for other confounders (hazard ratio [HR], 1.46; 95% confidence interval [CI], 1.04 to 2.03). In a subgroup analysis based on the mean age of death, among those who were 75 years and older (n=1,231), the risk of all-cause death was significantly higher in patients with glaucoma than in those without glaucoma (HR, 1.89; 95% CI, 1.24 to 1.89). CONCLUSIONS Participants with glaucoma had a higher risk of all-cause mortality, especially those aged 75 years and above. Our findings revealed potential mechanisms underlying an association between glaucoma and all-cause mortality. They also highlighted the importance of glaucoma management to prevent premature death in middle-aged and older adults.http://www.e-epih.org/upload/epih-45-e2023066.pdfglaucomamortalitychina health and retirement longitudinal studyrisk factors |
| spellingShingle | Xiaoxu Huang Mengqiao Xu Minwen Zhou Wenjia Liu Xiaohuan Zhao Xiaodong Sun The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study Epidemiology and Health glaucoma mortality china health and retirement longitudinal study risk factors |
| title | The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study |
| title_full | The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study |
| title_fullStr | The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study |
| title_full_unstemmed | The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study |
| title_short | The association between glaucoma and all-cause mortality in middle-aged and elderly Chinese people: results from the China Health and Retirement Longitudinal Study |
| title_sort | association between glaucoma and all cause mortality in middle aged and elderly chinese people results from the china health and retirement longitudinal study |
| topic | glaucoma mortality china health and retirement longitudinal study risk factors |
| url | http://www.e-epih.org/upload/epih-45-e2023066.pdf |
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