No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study
Based on previous observational studies, the causal association between circulating adiponectin (CA) levels and ankylosing spondylitis (AS) risk remains unclear. Therefore, this study aims to investigate whether CA levels are related to the risk of AS. We carried out a bidirectional two-sample Mende...
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MDPI AG
2022-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/12/2270 |
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| author | Jiale Xie Mingyi Yang Hui Yu Ke Xu Xianjie Wan Jiachen Wang Guoqiang Wang Peng Xu |
| author_facet | Jiale Xie Mingyi Yang Hui Yu Ke Xu Xianjie Wan Jiachen Wang Guoqiang Wang Peng Xu |
| author_sort | Jiale Xie |
| collection | DOAJ |
| description | Based on previous observational studies, the causal association between circulating adiponectin (CA) levels and ankylosing spondylitis (AS) risk remains unclear. Therefore, this study aims to investigate whether CA levels are related to the risk of AS. We carried out a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal correlation between CA levels and AS via published genome-wide association study (GWAS) datasets. Single-nucleotide polymorphisms (SNPs) related to CA levels were derived from a large GWAS that included 39,883 individuals of European descent. SNPs related to AS were obtained from the FinnGen consortium (2252 cases and 227,338 controls). The random-effects inverse variance weighted (IVW) method was the primary method utilized in our research. We also used four complementary approaches to improve the dependability of this study (MR–Egger regression, Weighted median, Weighted mode, and Simple mode). Random-effects IVW (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.79–1.27, <i>p</i> = 0.984) and four complementary methods all indicated that genetically predicted CA levels were not causally related to the risk of AS. In reverse MR analysis, there is little evidence to support the genetic causality between the risk of AS and CA levels. |
| first_indexed | 2024-03-09T16:29:12Z |
| format | Article |
| id | doaj.art-2548c3bebde246afaa9a04446049ff91 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T16:29:12Z |
| publishDate | 2022-12-01 |
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| series | Genes |
| spelling | doaj.art-2548c3bebde246afaa9a04446049ff912023-11-24T15:04:00ZengMDPI AGGenes2073-44252022-12-011312227010.3390/genes13122270No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization StudyJiale Xie0Mingyi Yang1Hui Yu2Ke Xu3Xianjie Wan4Jiachen Wang5Guoqiang Wang6Peng Xu7Department of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaDepartment of Joint Surgery, HongHui Hospital, Xi’an Jiaotong University, Xi’an 710054, ChinaBased on previous observational studies, the causal association between circulating adiponectin (CA) levels and ankylosing spondylitis (AS) risk remains unclear. Therefore, this study aims to investigate whether CA levels are related to the risk of AS. We carried out a bidirectional two-sample Mendelian randomization (MR) analysis to examine the causal correlation between CA levels and AS via published genome-wide association study (GWAS) datasets. Single-nucleotide polymorphisms (SNPs) related to CA levels were derived from a large GWAS that included 39,883 individuals of European descent. SNPs related to AS were obtained from the FinnGen consortium (2252 cases and 227,338 controls). The random-effects inverse variance weighted (IVW) method was the primary method utilized in our research. We also used four complementary approaches to improve the dependability of this study (MR–Egger regression, Weighted median, Weighted mode, and Simple mode). Random-effects IVW (odds ratio [OR], 1.00; 95% confidence interval [CI], 0.79–1.27, <i>p</i> = 0.984) and four complementary methods all indicated that genetically predicted CA levels were not causally related to the risk of AS. In reverse MR analysis, there is little evidence to support the genetic causality between the risk of AS and CA levels.https://www.mdpi.com/2073-4425/13/12/2270ankylosing spondylitiscirculating adiponectin levelssingle-nucleotide polymorphismscausalMendelian randomization |
| spellingShingle | Jiale Xie Mingyi Yang Hui Yu Ke Xu Xianjie Wan Jiachen Wang Guoqiang Wang Peng Xu No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study Genes ankylosing spondylitis circulating adiponectin levels single-nucleotide polymorphisms causal Mendelian randomization |
| title | No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study |
| title_full | No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study |
| title_fullStr | No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study |
| title_full_unstemmed | No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study |
| title_short | No Evidence to Support a Causal Relationship between Circulating Adiponectin Levels and Ankylosing Spondylitis: A Bidirectional Two-Sample Mendelian Randomization Study |
| title_sort | no evidence to support a causal relationship between circulating adiponectin levels and ankylosing spondylitis a bidirectional two sample mendelian randomization study |
| topic | ankylosing spondylitis circulating adiponectin levels single-nucleotide polymorphisms causal Mendelian randomization |
| url | https://www.mdpi.com/2073-4425/13/12/2270 |
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