Indocyanine green: An old drug with novel applications
Indocyanine green (ICG), a US Food and Drug Administration-approved fluorescent compound, has been on the medical stage for more than 60 years. Current uses include hepatic function evaluation before surgical procedure and fundus evaluation. The large safety margin and near-infrared fluorescent opti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Tzu-Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=4;spage=317;epage=322;aulast=Lu |
| _version_ | 1818733105717968896 |
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| author | Chia-Hung Lu Jong-Kai Hsiao |
| author_facet | Chia-Hung Lu Jong-Kai Hsiao |
| author_sort | Chia-Hung Lu |
| collection | DOAJ |
| description | Indocyanine green (ICG), a US Food and Drug Administration-approved fluorescent compound, has been on the medical stage for more than 60 years. Current uses include hepatic function evaluation before surgical procedure and fundus evaluation. The large safety margin and near-infrared fluorescent optical advantage of the drug have proved useful in several clinical trials of intraoperative systems for tumor removal. Several nanoparticle-sized formulations for thermal ablation and photodynamic therapy have also been evaluated in animal experiments. Studies have attempted to manipulate ICG as a reporter fluorophore with initial success. In this article, we reviewed ICG's histological applications, chemical and physical properties, current clinical applications, ongoing clinical trials, and biomedical studies and prospects. We believe that ICG could be used with novel biotechnological techniques, such as fluorescent endoscopy and photoacoustic equipment, in a range of biomedical fields. |
| first_indexed | 2024-12-17T23:44:11Z |
| format | Article |
| id | doaj.art-254a101604fc4f968c4aa75f6bd1e186 |
| institution | Directory Open Access Journal |
| issn | 1016-3190 2223-8956 |
| language | English |
| last_indexed | 2024-12-17T23:44:11Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu-Chi Medical Journal |
| spelling | doaj.art-254a101604fc4f968c4aa75f6bd1e1862022-12-21T21:28:22ZengWolters Kluwer Medknow PublicationsTzu-Chi Medical Journal1016-31902223-89562021-01-0133431732210.4103/tcmj.tcmj_216_20Indocyanine green: An old drug with novel applicationsChia-Hung LuJong-Kai HsiaoIndocyanine green (ICG), a US Food and Drug Administration-approved fluorescent compound, has been on the medical stage for more than 60 years. Current uses include hepatic function evaluation before surgical procedure and fundus evaluation. The large safety margin and near-infrared fluorescent optical advantage of the drug have proved useful in several clinical trials of intraoperative systems for tumor removal. Several nanoparticle-sized formulations for thermal ablation and photodynamic therapy have also been evaluated in animal experiments. Studies have attempted to manipulate ICG as a reporter fluorophore with initial success. In this article, we reviewed ICG's histological applications, chemical and physical properties, current clinical applications, ongoing clinical trials, and biomedical studies and prospects. We believe that ICG could be used with novel biotechnological techniques, such as fluorescent endoscopy and photoacoustic equipment, in a range of biomedical fields.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=4;spage=317;epage=322;aulast=Lufluorescent dyeindocyanine greennear-infraredoptical imaging |
| spellingShingle | Chia-Hung Lu Jong-Kai Hsiao Indocyanine green: An old drug with novel applications Tzu-Chi Medical Journal fluorescent dye indocyanine green near-infrared optical imaging |
| title | Indocyanine green: An old drug with novel applications |
| title_full | Indocyanine green: An old drug with novel applications |
| title_fullStr | Indocyanine green: An old drug with novel applications |
| title_full_unstemmed | Indocyanine green: An old drug with novel applications |
| title_short | Indocyanine green: An old drug with novel applications |
| title_sort | indocyanine green an old drug with novel applications |
| topic | fluorescent dye indocyanine green near-infrared optical imaging |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2021;volume=33;issue=4;spage=317;epage=322;aulast=Lu |
| work_keys_str_mv | AT chiahunglu indocyaninegreenanolddrugwithnovelapplications AT jongkaihsiao indocyaninegreenanolddrugwithnovelapplications |