Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study
Abstract Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old communi...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03290-8 |
| _version_ | 1797774070084796416 |
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| author | Thiago Cardoso Vale Francisco Eduardo Costa Cardoso Danilo Jorge da Silva Elisa de Paula Franca Resende Débora Palma Maia Mauro César Quintão Cunningham Henrique Cerqueira Guimarães João Carlos Barbosa Machado Antônio Lúcio Teixeira Paulo Caramelli Maira Tonidandel Barbosa |
| author_facet | Thiago Cardoso Vale Francisco Eduardo Costa Cardoso Danilo Jorge da Silva Elisa de Paula Franca Resende Débora Palma Maia Mauro César Quintão Cunningham Henrique Cerqueira Guimarães João Carlos Barbosa Machado Antônio Lúcio Teixeira Paulo Caramelli Maira Tonidandel Barbosa |
| author_sort | Thiago Cardoso Vale |
| collection | DOAJ |
| description | Abstract Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample. |
| first_indexed | 2024-03-12T22:15:39Z |
| format | Article |
| id | doaj.art-254a2c529dd642ecaf46ed62289f5aed |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-12T22:15:39Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-254a2c529dd642ecaf46ed62289f5aed2023-07-23T11:17:48ZengBMCBMC Neurology1471-23772023-07-012311910.1186/s12883-023-03290-8Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà studyThiago Cardoso Vale0Francisco Eduardo Costa Cardoso1Danilo Jorge da Silva2Elisa de Paula Franca Resende3Débora Palma Maia4Mauro César Quintão Cunningham5Henrique Cerqueira Guimarães6João Carlos Barbosa Machado7Antônio Lúcio Teixeira8Paulo Caramelli9Maira Tonidandel Barbosa10Internal Medicine Department, Faculdade de Medicina, Universidade Federal de Juiz de ForaMovement Disorders Unit, Hospital das Clínicas, Universidade Federal de Minas GeraisInternal Medicine Department, Faculdade de Medicina, Universidade Federal de Juiz de ForaBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas GeraisMovement Disorders Unit, Hospital das Clínicas, Universidade Federal de Minas GeraisMovement Disorders Unit, Hospital das Clínicas, Universidade Federal de Minas GeraisBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas GeraisFaculdade de Ciências Médicas de Minas GeraisBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas GeraisBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas GeraisBehavioral and Cognitive Neurology Unit, Faculdade de Medicina, Universidade Federal de Minas GeraisAbstract Background Parkinsonism is strongly associated with ageing, and many studies have suggested that parkinsonian signs may affect up to half of older adults and is associated with a wide range of adverse health outcomes. We compared clinical and functional characteristics of oldest-old community-dwelling individuals with parkinsonism (parkinsonian group [PG]) to individuals without parkinsonism (non-parkinsonian group [NPG]. Methods The Pietà study is a population-based study conducted in Caeté, southeast Brazil, involving 607 individuals aged 75 + years submitted to an extensive clinical evaluation. A subset of 65 PG individuals (61.5% women, median age of 82 years) was compared to 542 NPG individuals (64.8% women, median age of 80 years). Results PG individuals had significantly more functional impairment, clinical comorbidities (including number of falls, loss of bladder control and dysphagia) and major depression. Multivariate analysis revealed that older age, higher UPDRSm scores, lower category fluency test (animals/minute) and delayed recall memory scores were associated with PG. This group was also more cognitively impaired, with lower performance than NPG individuals in the Mini-Mental State Examination, category fluency test (animals/minute), clock drawing and in delayed recall (p < 0.001 for all tests). UPDRSm scores were the most contributing factor to cognition that independently explained variability in functionality of the entire sample. Conclusion Individuals aged 75 + years with parkinsonism were significantly more clinically and functionally impaired in this population-based sample. Cognitive dysfunction explained most of the loss of functionality in these patients. UPDRS-m scores contributed independently to explain variability in functionality in the whole sample.https://doi.org/10.1186/s12883-023-03290-8ParkinsonismParkinson’s diseaseDementiaAlzheimer’s diseaseFunctional decline |
| spellingShingle | Thiago Cardoso Vale Francisco Eduardo Costa Cardoso Danilo Jorge da Silva Elisa de Paula Franca Resende Débora Palma Maia Mauro César Quintão Cunningham Henrique Cerqueira Guimarães João Carlos Barbosa Machado Antônio Lúcio Teixeira Paulo Caramelli Maira Tonidandel Barbosa Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study BMC Neurology Parkinsonism Parkinson’s disease Dementia Alzheimer’s disease Functional decline |
| title | Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study |
| title_full | Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study |
| title_fullStr | Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study |
| title_full_unstemmed | Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study |
| title_short | Clinical and functional correlates of parkinsonism in a population-based sample of individuals aged 75 + : the Pietà study |
| title_sort | clinical and functional correlates of parkinsonism in a population based sample of individuals aged 75 the pieta study |
| topic | Parkinsonism Parkinson’s disease Dementia Alzheimer’s disease Functional decline |
| url | https://doi.org/10.1186/s12883-023-03290-8 |
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