Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications
Within the last couple of years, the understanding of the molecular mechanisms that drive the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has significantly improved. Large-scale gene expression profiling studies have led to the discovery of several molecularly defined subtypes that are cha...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-05-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/7/2/0812 |
| _version_ | 1797715152508813312 |
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| author | Georg Lenz |
| author_facet | Georg Lenz |
| author_sort | Georg Lenz |
| collection | DOAJ |
| description | Within the last couple of years, the understanding of the molecular mechanisms that drive the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has significantly improved. Large-scale gene expression profiling studies have led to the discovery of several molecularly defined subtypes that are characterized by specific oncogene addictions and significant differences in their outcome. Next generation sequencing efforts combined with RNA interference screens frequently identify crucial oncogenes that lead to constitutive activation of various signaling pathways that drive lymphomagenesis. This review summarizes our current understanding of the molecular pathogenesis of the activated B-cell-like (ABC) DLBCL subtype that is characterized by poor prognosis. A special emphasis is put on findings that might impact therapeutic strategies of affected patients. |
| first_indexed | 2024-03-12T08:02:41Z |
| format | Article |
| id | doaj.art-254b28af129340c185056e66133ce66a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T08:02:41Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-254b28af129340c185056e66133ce66a2023-09-02T19:44:02ZengMDPI AGCancers2072-66942015-05-017281182210.3390/cancers7020812cancers7020812Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic ImplicationsGeorg Lenz0Translational Oncology, Department of Medicine A, Albert-Schweitzer Campus 1, University Hospital Münster, 48149 Münster, GermanyWithin the last couple of years, the understanding of the molecular mechanisms that drive the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has significantly improved. Large-scale gene expression profiling studies have led to the discovery of several molecularly defined subtypes that are characterized by specific oncogene addictions and significant differences in their outcome. Next generation sequencing efforts combined with RNA interference screens frequently identify crucial oncogenes that lead to constitutive activation of various signaling pathways that drive lymphomagenesis. This review summarizes our current understanding of the molecular pathogenesis of the activated B-cell-like (ABC) DLBCL subtype that is characterized by poor prognosis. A special emphasis is put on findings that might impact therapeutic strategies of affected patients.http://www.mdpi.com/2072-6694/7/2/0812ABC DLBCLNF-B pathwayB-cell receptor signalingmolecular targets |
| spellingShingle | Georg Lenz Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications Cancers ABC DLBCL NF-B pathway B-cell receptor signaling molecular targets |
| title | Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications |
| title_full | Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications |
| title_fullStr | Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications |
| title_full_unstemmed | Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications |
| title_short | Insights into the Molecular Pathogenesis of Activated B-Cell-like Diffuse Large B-Cell Lymphoma and Its Therapeutic Implications |
| title_sort | insights into the molecular pathogenesis of activated b cell like diffuse large b cell lymphoma and its therapeutic implications |
| topic | ABC DLBCL NF-B pathway B-cell receptor signaling molecular targets |
| url | http://www.mdpi.com/2072-6694/7/2/0812 |
| work_keys_str_mv | AT georglenz insightsintothemolecularpathogenesisofactivatedbcelllikediffuselargebcelllymphomaanditstherapeuticimplications |