Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour
Inflammatory myofibroblastic tumour (IMT) is a rare tumour with an intermediate biological behaviour. It usually occurs in children and adolescents, primarily in the abdomen or lungs. Histopathologically, IMT consists of spindle cells, i.e., myofibroblasts, and a variable inflammatory component. Loc...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/4/791 |
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| author | Nebojsa Prijovic Veljko Santric Uros Babic Branko Stankovic Miodrag Acimovic Milica Cekerevac Gorana Nikolic Bojan Cegar |
| author_facet | Nebojsa Prijovic Veljko Santric Uros Babic Branko Stankovic Miodrag Acimovic Milica Cekerevac Gorana Nikolic Bojan Cegar |
| author_sort | Nebojsa Prijovic |
| collection | DOAJ |
| description | Inflammatory myofibroblastic tumour (IMT) is a rare tumour with an intermediate biological behaviour. It usually occurs in children and adolescents, primarily in the abdomen or lungs. Histopathologically, IMT consists of spindle cells, i.e., myofibroblasts, and a variable inflammatory component. Localization in the urinary bladder is rare. We are presenting a rare case of IMT in the bladder in a middle-aged man treated by partial cystectomy. A 62-year-old man consulted a urologist because of haematuria and dysuric disturbances. A tumorous mass was detected by an ultrasound in the urinary bladder. CT urography described the tumorous mass at the dome of the urinary bladder measuring 2 × 5 cm. A smooth tumorous mass was cystoscopically observed at the dome of the urinary bladder. Transurethral resection of the bladder tumour was performed. Histopathological analysis of the specimen identified spindle cells with a mixed inflammatory infiltrate; immunohistochemical findings showed positivity for anaplastic lymphoma kinase (ALK), smooth muscle actin (SMA) and vimentin. A histopathological diagnosis of IMT was established. It was decided that the patient would undergo a partial cystectomy. A complete excision of the tumour from the dome of the urinary bladder with surrounding healthy tissue was performed. Histopathological and immunohistochemical findings of the sample confirmed the diagnosis of IMT, without the presence of the tumour at the surgical margins. The postoperative course went smoothly. IMT is a rare tumour in adults, especially localised in the urinary bladder. IMT of the urinary bladder is difficult to distinguish from urinary bladder malignancy both clinically and radiologically, as well as histopathologically. If the location and size of the tumour allow it, bladder-preserving surgeries such as partial cystectomy represent a reasonable modality of operative treatment. |
| first_indexed | 2024-03-11T04:45:25Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T04:45:25Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-254b89b78ef246a087f9cf94f44639742023-11-17T20:22:09ZengMDPI AGMedicina1010-660X1648-91442023-04-0159479110.3390/medicina59040791Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare TumourNebojsa Prijovic0Veljko Santric1Uros Babic2Branko Stankovic3Miodrag Acimovic4Milica Cekerevac5Gorana Nikolic6Bojan Cegar7Clinic of Urology, University Clinical Center of Serbia, 11000 Belgrade, SerbiaClinic of Urology, University Clinical Center of Serbia, 11000 Belgrade, SerbiaClinic of Urology, University Clinical Center of Serbia, 11000 Belgrade, SerbiaClinic of Urology, University Clinical Center of Serbia, 11000 Belgrade, SerbiaClinic of Urology, University Clinical Center of Serbia, 11000 Belgrade, SerbiaDepartment of Pathology, University Clinical Centre of Serbia, 11000 Belgrade, SerbiaFaculty of Medicine, University of Belgrade, 11000 Belgrade, SerbiaClinic of Urology, University Clinical Center of Serbia, 11000 Belgrade, SerbiaInflammatory myofibroblastic tumour (IMT) is a rare tumour with an intermediate biological behaviour. It usually occurs in children and adolescents, primarily in the abdomen or lungs. Histopathologically, IMT consists of spindle cells, i.e., myofibroblasts, and a variable inflammatory component. Localization in the urinary bladder is rare. We are presenting a rare case of IMT in the bladder in a middle-aged man treated by partial cystectomy. A 62-year-old man consulted a urologist because of haematuria and dysuric disturbances. A tumorous mass was detected by an ultrasound in the urinary bladder. CT urography described the tumorous mass at the dome of the urinary bladder measuring 2 × 5 cm. A smooth tumorous mass was cystoscopically observed at the dome of the urinary bladder. Transurethral resection of the bladder tumour was performed. Histopathological analysis of the specimen identified spindle cells with a mixed inflammatory infiltrate; immunohistochemical findings showed positivity for anaplastic lymphoma kinase (ALK), smooth muscle actin (SMA) and vimentin. A histopathological diagnosis of IMT was established. It was decided that the patient would undergo a partial cystectomy. A complete excision of the tumour from the dome of the urinary bladder with surrounding healthy tissue was performed. Histopathological and immunohistochemical findings of the sample confirmed the diagnosis of IMT, without the presence of the tumour at the surgical margins. The postoperative course went smoothly. IMT is a rare tumour in adults, especially localised in the urinary bladder. IMT of the urinary bladder is difficult to distinguish from urinary bladder malignancy both clinically and radiologically, as well as histopathologically. If the location and size of the tumour allow it, bladder-preserving surgeries such as partial cystectomy represent a reasonable modality of operative treatment.https://www.mdpi.com/1648-9144/59/4/791inflammatory myofibroblastic tumoururinary bladderpartial cystectomy |
| spellingShingle | Nebojsa Prijovic Veljko Santric Uros Babic Branko Stankovic Miodrag Acimovic Milica Cekerevac Gorana Nikolic Bojan Cegar Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour Medicina inflammatory myofibroblastic tumour urinary bladder partial cystectomy |
| title | Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour |
| title_full | Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour |
| title_fullStr | Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour |
| title_full_unstemmed | Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour |
| title_short | Inflammatory Myofibroblastic Tumour of the Urinary Bladder in a Middle-Aged Man—A Case Report of an Unusual Localization of a Rare Tumour |
| title_sort | inflammatory myofibroblastic tumour of the urinary bladder in a middle aged man a case report of an unusual localization of a rare tumour |
| topic | inflammatory myofibroblastic tumour urinary bladder partial cystectomy |
| url | https://www.mdpi.com/1648-9144/59/4/791 |
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