HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications
Behçet’s disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, inclu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-09-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4915/10/9/511 |
| _version_ | 1819298002461786112 |
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| author | S. M. Shamsul Islam Seonghyang Sohn |
| author_facet | S. M. Shamsul Islam Seonghyang Sohn |
| author_sort | S. M. Shamsul Islam |
| collection | DOAJ |
| description | Behçet’s disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, including environmental, genetic, viral, and immunological factors. To understand its complex etiology and improve its management, animal models of BD have been used to enable more effective therapeutic applications with increased clinical significance. An herpes simplex virus (HSV) type 1-induced BD mouse model has shown disease characteristics similar to those seen in BD patients. An HSV-induced BD animal model has been used to test various therapeutic modalities. The applied modalities are several materials that are derived from natural products, conventional therapeutics, and possible biologics. In this review, we provided how they regulate inflammation in an HSV-induced BD model. |
| first_indexed | 2024-12-24T05:22:58Z |
| format | Article |
| id | doaj.art-254c47976431476c94ca0bb3b4244f6d |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-24T05:22:58Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-254c47976431476c94ca0bb3b4244f6d2022-12-21T17:13:25ZengMDPI AGViruses1999-49152018-09-0110951110.3390/v10090511v10090511HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic ApplicationsS. M. Shamsul Islam0Seonghyang Sohn1Department of Biomedical Science, Ajou University School of Medicine, Suwon 16499, KoreaDepartment of Biomedical Science, Ajou University School of Medicine, Suwon 16499, KoreaBehçet’s disease (BD) affects multiple organs. It is mainly characterized by recurrent oral, skin, and genital aphthous ulcers, and eye involvement. Successful management of BD is increasing, although its etiology remains unclear. A number of etiologies have been proposed, including environmental, genetic, viral, and immunological factors. To understand its complex etiology and improve its management, animal models of BD have been used to enable more effective therapeutic applications with increased clinical significance. An herpes simplex virus (HSV) type 1-induced BD mouse model has shown disease characteristics similar to those seen in BD patients. An HSV-induced BD animal model has been used to test various therapeutic modalities. The applied modalities are several materials that are derived from natural products, conventional therapeutics, and possible biologics. In this review, we provided how they regulate inflammation in an HSV-induced BD model.http://www.mdpi.com/1999-4915/10/9/511Behçet’s diseaseherpes simplex virusanimal modelapplication |
| spellingShingle | S. M. Shamsul Islam Seonghyang Sohn HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications Viruses Behçet’s disease herpes simplex virus animal model application |
| title | HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications |
| title_full | HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications |
| title_fullStr | HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications |
| title_full_unstemmed | HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications |
| title_short | HSV-Induced Systemic Inflammation as an Animal Model for Behçet’s Disease and Therapeutic Applications |
| title_sort | hsv induced systemic inflammation as an animal model for behcet s disease and therapeutic applications |
| topic | Behçet’s disease herpes simplex virus animal model application |
| url | http://www.mdpi.com/1999-4915/10/9/511 |
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