Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis
Abstract Soil-transmitted Helminth (STH) infections have been found associated with people living with human immunodeficiency virus (HIV) but little is known about the overall burden of STH coinfection in HIV patients. We aimed to assess the burden of STH infections among HIV patients. Relevant data...
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| Format: | Article |
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Nature Portfolio
2023-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-38030-y |
| _version_ | 1827905418476650496 |
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| author | Kumari Akanksha Ashu Kumari Omprokash Dutta Ajay Prasanth Farah Deeba Nasir Salam |
| author_facet | Kumari Akanksha Ashu Kumari Omprokash Dutta Ajay Prasanth Farah Deeba Nasir Salam |
| author_sort | Kumari Akanksha |
| collection | DOAJ |
| description | Abstract Soil-transmitted Helminth (STH) infections have been found associated with people living with human immunodeficiency virus (HIV) but little is known about the overall burden of STH coinfection in HIV patients. We aimed to assess the burden of STH infections among HIV patients. Relevant databases were systematically searched for studies reporting the prevalence of soil-transmitted helminthic pathogens in HIV patients. Pooled estimates of each helminthic infection were calculated. The odds ratio was also determined as a measure of the association between STH infection and the HIV status of the patients. Sixty-one studies were finally included in the meta-analysis, consisting of 16,203 human subjects from all over the world. The prevalence of Ascaris lumbricoides infection in HIV patients was found to be 8% (95% CI 0.06, 0.09), the prevalence of Trichuris trichiura infection in HIV patients was found to be 5% (95% CI 0.04, 0.06), the prevalence of hookworm infection in HIV patients was found to be 5% (95% CI 0.04, 0.06), and prevalence of Strongyloides stercoralis infection in HIV patients was found to be 5% (95% CI 0.04, 0.05). Countries from Sub-Saharan Africa, Latin America & Caribbean and Asia were identified with the highest burden of STH-HIV coinfection. Our analysis indicated that people living with HIV have a higher chance of developing Strongyloides stercoralis infections and decreased odds of developing hookworm infections. Our findings suggest a moderate level of prevalence of STH infections among people living with HIV. The endemicity of STH infections and HIV status both are partially responsible for the burden of STH-HIV coinfections. |
| first_indexed | 2024-03-13T00:42:21Z |
| format | Article |
| id | doaj.art-254c9c7ff01647738d6dde1baaa9617e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-13T00:42:21Z |
| publishDate | 2023-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-254c9c7ff01647738d6dde1baaa9617e2023-07-09T11:14:42ZengNature PortfolioScientific Reports2045-23222023-07-0113111110.1038/s41598-023-38030-yPrevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysisKumari Akanksha0Ashu Kumari1Omprokash Dutta2Ajay Prasanth3Farah Deeba4Nasir Salam5Department of Microbiology, Central University of PunjabDepartment of Microbiology, Central University of PunjabDepartment of Microbiology, Central University of PunjabDepartment of Microbiology, Central University of PunjabCentre for Interdisciplinary Research in Basic Sciences, Jamia Millia IslamiaDepartment of Microbiology, Central University of PunjabAbstract Soil-transmitted Helminth (STH) infections have been found associated with people living with human immunodeficiency virus (HIV) but little is known about the overall burden of STH coinfection in HIV patients. We aimed to assess the burden of STH infections among HIV patients. Relevant databases were systematically searched for studies reporting the prevalence of soil-transmitted helminthic pathogens in HIV patients. Pooled estimates of each helminthic infection were calculated. The odds ratio was also determined as a measure of the association between STH infection and the HIV status of the patients. Sixty-one studies were finally included in the meta-analysis, consisting of 16,203 human subjects from all over the world. The prevalence of Ascaris lumbricoides infection in HIV patients was found to be 8% (95% CI 0.06, 0.09), the prevalence of Trichuris trichiura infection in HIV patients was found to be 5% (95% CI 0.04, 0.06), the prevalence of hookworm infection in HIV patients was found to be 5% (95% CI 0.04, 0.06), and prevalence of Strongyloides stercoralis infection in HIV patients was found to be 5% (95% CI 0.04, 0.05). Countries from Sub-Saharan Africa, Latin America & Caribbean and Asia were identified with the highest burden of STH-HIV coinfection. Our analysis indicated that people living with HIV have a higher chance of developing Strongyloides stercoralis infections and decreased odds of developing hookworm infections. Our findings suggest a moderate level of prevalence of STH infections among people living with HIV. The endemicity of STH infections and HIV status both are partially responsible for the burden of STH-HIV coinfections.https://doi.org/10.1038/s41598-023-38030-y |
| spellingShingle | Kumari Akanksha Ashu Kumari Omprokash Dutta Ajay Prasanth Farah Deeba Nasir Salam Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis Scientific Reports |
| title | Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis |
| title_full | Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis |
| title_fullStr | Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis |
| title_short | Prevalence of soil-transmitted helminth infections in HIV patients: a systematic review and meta-analysis |
| title_sort | prevalence of soil transmitted helminth infections in hiv patients a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-023-38030-y |
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