Subtle changes of the crystalline lens after cycloplegia: a retrospective study
Abstract Background The purpose of this study was to evaluate the shape of the crystalline lens in terms of biometry and diopters before and after cycloplegia using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment. Methods This was a retrospective study....
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BMC
2021-03-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-021-01884-9 |
| _version_ | 1819163815881736192 |
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| author | Cheng Dai Meng Liu Xiaodong Lv Binzhong Li |
| author_facet | Cheng Dai Meng Liu Xiaodong Lv Binzhong Li |
| author_sort | Cheng Dai |
| collection | DOAJ |
| description | Abstract Background The purpose of this study was to evaluate the shape of the crystalline lens in terms of biometry and diopters before and after cycloplegia using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment. Methods This was a retrospective study. Children and adolescents (26 males and 29 females, aged 4–21 years) with simple ametropia were selected for optometry and CASIA2 imaging at 2 separate visits before and after cycloplegia. Diopter values were derived from the spherical power (S) obtained by optometry. Biometric parameters of the crystalline lens, including the anterior chamber depth (ACD), anterior and posterior curvature of the lens (ACL and PCL), lens thickness (LTH), lens decentration (LD), lens tilt (LT), and equivalent diameter of the lens (LED), were measured by the CASIA2 system. The differences in these parameters after compared with before cycloplegia were determined, and their relationships were analyzed. Results Fifty-five participants (106 eyes) were initially enrolled. There was a significant difference (P < 0.05) in the S (t=-7.026, P < 0.001), ACD (t=-8.796, P < 0.001), ACL (t=-13.263, P < 0.001) and LTH (t = 7.363, P < 0.001) after compared with before cycloplegia. The change in the PCL (t = 1.557, P = 0.122), LD (t = 0.876, P = 0.383), LT (t = 0.440, P = 0.661) and LED (t=-0.351, P = 0.726) was not statistically significant (P > 0.05). There was a significant (P < 0.05) correlation of the change in the S with that in the ACL (r = 0.466, P < 0.001), LTH (r=-0.592, P < 0.001), and LED (r = 0.223, P = 0.021) but not the PCL (r = 0.19, P = 0.051), LD (r=-0.048, P = 0.0628) or LT (r=-0.022, P = 0.822). Furthermore, the change in the ACD was closely related to the change in crystalline morphology. However, in children and adolescents, we found that the change in crystalline morphology was unrelated to age. Conclusions Changes in lens morphology after compared with before cycloplegia are mainly related to the ACL and LTH, but there is no difference in the PCL, LD, LT, or LED. In the adolescent population, change in the S is related to change in the ACL, LED and LTH. However, age is unrelated to the shape and tendency of the crystalline lens. Further research is required to determine whether the same conclusion applies to different age groups and different refractive states (myopia, hyperopia, emmetropia) . |
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| id | doaj.art-254e727d1ff14c118559f29cd369fe6b |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-22T17:50:08Z |
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| spelling | doaj.art-254e727d1ff14c118559f29cd369fe6b2022-12-21T18:18:11ZengBMCBMC Ophthalmology1471-24152021-03-012111610.1186/s12886-021-01884-9Subtle changes of the crystalline lens after cycloplegia: a retrospective studyCheng Dai0Meng Liu1Xiaodong Lv2Binzhong Li3School of Basic Medicine, North Sichuan Medical CollegeSchool of Basic Medicine, North Sichuan Medical CollegeDepartment of Clinical Medicine, North Sichuan Medical CollegeSchool of Basic Medicine, North Sichuan Medical CollegeAbstract Background The purpose of this study was to evaluate the shape of the crystalline lens in terms of biometry and diopters before and after cycloplegia using the CASIA2 swept-source (SS) optical coherence tomography (OCT) system on the anterior segment. Methods This was a retrospective study. Children and adolescents (26 males and 29 females, aged 4–21 years) with simple ametropia were selected for optometry and CASIA2 imaging at 2 separate visits before and after cycloplegia. Diopter values were derived from the spherical power (S) obtained by optometry. Biometric parameters of the crystalline lens, including the anterior chamber depth (ACD), anterior and posterior curvature of the lens (ACL and PCL), lens thickness (LTH), lens decentration (LD), lens tilt (LT), and equivalent diameter of the lens (LED), were measured by the CASIA2 system. The differences in these parameters after compared with before cycloplegia were determined, and their relationships were analyzed. Results Fifty-five participants (106 eyes) were initially enrolled. There was a significant difference (P < 0.05) in the S (t=-7.026, P < 0.001), ACD (t=-8.796, P < 0.001), ACL (t=-13.263, P < 0.001) and LTH (t = 7.363, P < 0.001) after compared with before cycloplegia. The change in the PCL (t = 1.557, P = 0.122), LD (t = 0.876, P = 0.383), LT (t = 0.440, P = 0.661) and LED (t=-0.351, P = 0.726) was not statistically significant (P > 0.05). There was a significant (P < 0.05) correlation of the change in the S with that in the ACL (r = 0.466, P < 0.001), LTH (r=-0.592, P < 0.001), and LED (r = 0.223, P = 0.021) but not the PCL (r = 0.19, P = 0.051), LD (r=-0.048, P = 0.0628) or LT (r=-0.022, P = 0.822). Furthermore, the change in the ACD was closely related to the change in crystalline morphology. However, in children and adolescents, we found that the change in crystalline morphology was unrelated to age. Conclusions Changes in lens morphology after compared with before cycloplegia are mainly related to the ACL and LTH, but there is no difference in the PCL, LD, LT, or LED. In the adolescent population, change in the S is related to change in the ACL, LED and LTH. However, age is unrelated to the shape and tendency of the crystalline lens. Further research is required to determine whether the same conclusion applies to different age groups and different refractive states (myopia, hyperopia, emmetropia) .https://doi.org/10.1186/s12886-021-01884-9CycloplegiaCASIA2Lens biometryAmetropia |
| spellingShingle | Cheng Dai Meng Liu Xiaodong Lv Binzhong Li Subtle changes of the crystalline lens after cycloplegia: a retrospective study BMC Ophthalmology Cycloplegia CASIA2 Lens biometry Ametropia |
| title | Subtle changes of the crystalline lens after cycloplegia: a retrospective study |
| title_full | Subtle changes of the crystalline lens after cycloplegia: a retrospective study |
| title_fullStr | Subtle changes of the crystalline lens after cycloplegia: a retrospective study |
| title_full_unstemmed | Subtle changes of the crystalline lens after cycloplegia: a retrospective study |
| title_short | Subtle changes of the crystalline lens after cycloplegia: a retrospective study |
| title_sort | subtle changes of the crystalline lens after cycloplegia a retrospective study |
| topic | Cycloplegia CASIA2 Lens biometry Ametropia |
| url | https://doi.org/10.1186/s12886-021-01884-9 |
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