MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases
MicroRNAs (miRNAs) are a class of small non-coding RNAs that post-transcriptionally regulate the expression of approximately 50 % of all protein-coding genes. They have been demonstrated to act as key regulators in various pathophysiological processes and play significant roles in a wide range of hu...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S075333222300906X |
| _version_ | 1797744047014543360 |
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| author | Jiao Yang Xinfang Wang Wenjing Hao Ying Wang Zhongxun Li Qi Han Chunming Zhang Hongliang Liu |
| author_facet | Jiao Yang Xinfang Wang Wenjing Hao Ying Wang Zhongxun Li Qi Han Chunming Zhang Hongliang Liu |
| author_sort | Jiao Yang |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) are a class of small non-coding RNAs that post-transcriptionally regulate the expression of approximately 50 % of all protein-coding genes. They have been demonstrated to act as key regulators in various pathophysiological processes and play significant roles in a wide range of human diseases, particularly cancer. Current research highlights the aberrant expression of microRNA-488 (miR-488) in multiple human diseases and its critical involvement in disease initiation and progression. Moreover, the expression level of miR-488 has been linked to clinicopathological features and patient prognosis across different diseases. However, a comprehensive systematic review of miR-488 is lacking. Therefore, our study aims to consolidate the current knowledge surrounding miR-488, with a primary focus on its emerging biological functions, regulatory mechanisms, and potential clinical applications in human diseases. Through this review, we aim to establish a comprehensive understanding of the diverse roles of miR-488 in the development of various diseases. |
| first_indexed | 2024-03-12T15:05:05Z |
| format | Article |
| id | doaj.art-254f2ca184344cb1aedcdab42f747a7c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T15:05:05Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-254f2ca184344cb1aedcdab42f747a7c2023-08-13T04:52:38ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-09-01165115115MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseasesJiao Yang0Xinfang Wang1Wenjing Hao2Ying Wang3Zhongxun Li4Qi Han5Chunming Zhang6Hongliang Liu7Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Anatomy, the Basic Medical School of Shanxi Medical University, Taiyuan 030001, Shanxi, PR ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Cell biology and Genetics, the Basic Medical School of Shanxi Medical University, Taiyuan 030001, Shanxi, PR ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Cell biology and Genetics, the Basic Medical School of Shanxi Medical University, Taiyuan 030001, Shanxi, PR ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR ChinaShanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Corresponding authors at: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China.Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Department of Cell biology and Genetics, the Basic Medical School of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China; Corresponding authors at: Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi, PR China.MicroRNAs (miRNAs) are a class of small non-coding RNAs that post-transcriptionally regulate the expression of approximately 50 % of all protein-coding genes. They have been demonstrated to act as key regulators in various pathophysiological processes and play significant roles in a wide range of human diseases, particularly cancer. Current research highlights the aberrant expression of microRNA-488 (miR-488) in multiple human diseases and its critical involvement in disease initiation and progression. Moreover, the expression level of miR-488 has been linked to clinicopathological features and patient prognosis across different diseases. However, a comprehensive systematic review of miR-488 is lacking. Therefore, our study aims to consolidate the current knowledge surrounding miR-488, with a primary focus on its emerging biological functions, regulatory mechanisms, and potential clinical applications in human diseases. Through this review, we aim to establish a comprehensive understanding of the diverse roles of miR-488 in the development of various diseases.http://www.sciencedirect.com/science/article/pii/S075333222300906XMiR-488CancersHuman diseasesFunctional mechanismClinical applications |
| spellingShingle | Jiao Yang Xinfang Wang Wenjing Hao Ying Wang Zhongxun Li Qi Han Chunming Zhang Hongliang Liu MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases Biomedicine & Pharmacotherapy MiR-488 Cancers Human diseases Functional mechanism Clinical applications |
| title | MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases |
| title_full | MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases |
| title_fullStr | MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases |
| title_full_unstemmed | MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases |
| title_short | MicroRNA-488: A miRNA with diverse roles and clinical applications in cancer and other human diseases |
| title_sort | microrna 488 a mirna with diverse roles and clinical applications in cancer and other human diseases |
| topic | MiR-488 Cancers Human diseases Functional mechanism Clinical applications |
| url | http://www.sciencedirect.com/science/article/pii/S075333222300906X |
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