Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus Infections
Antibody-based passive immunotherapy has been used effectively in the treatment and prophylaxis of infectious diseases. Outbreaks of emerging viral infections from arthropod-borne viruses (arboviruses) represent a global public health problem due to their rapid spread, urging measures and the treatm...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
|
| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/15/11/2177 |
| _version_ | 1827638600161820672 |
|---|---|
| author | Leonardo F. Ormundo Carolina T. Barreto Lilian R. Tsuruta |
| author_facet | Leonardo F. Ormundo Carolina T. Barreto Lilian R. Tsuruta |
| author_sort | Leonardo F. Ormundo |
| collection | DOAJ |
| description | Antibody-based passive immunotherapy has been used effectively in the treatment and prophylaxis of infectious diseases. Outbreaks of emerging viral infections from arthropod-borne viruses (arboviruses) represent a global public health problem due to their rapid spread, urging measures and the treatment of infected individuals to combat them. Preparedness in advances in developing antivirals and relevant epidemiological studies protect us from damage and losses. Immunotherapy based on monoclonal antibodies (mAbs) has been shown to be very specific in combating infectious diseases and various other illnesses. Recent advances in mAb discovery techniques have allowed the development and approval of a wide number of therapeutic mAbs. This review focuses on the technological approaches available to select neutralizing mAbs for emerging arbovirus infections and the next-generation strategies to obtain highly effective and potent mAbs. The characteristics of mAbs developed as prophylactic and therapeutic antiviral agents for dengue, Zika, chikungunya, West Nile and tick-borne encephalitis virus are presented, as well as the protective effect demonstrated in animal model studies. |
| first_indexed | 2024-03-09T16:23:21Z |
| format | Article |
| id | doaj.art-254f4b46a48445d6b72c6d17ba8d2093 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T16:23:21Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-254f4b46a48445d6b72c6d17ba8d20932023-11-24T15:10:39ZengMDPI AGViruses1999-49152023-10-011511217710.3390/v15112177Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus InfectionsLeonardo F. Ormundo0Carolina T. Barreto1Lilian R. Tsuruta2Biopharmaceuticals Laboratory, Instituto Butantan, São Paulo 05503-900, BrazilBiopharmaceuticals Laboratory, Instituto Butantan, São Paulo 05503-900, BrazilBiopharmaceuticals Laboratory, Instituto Butantan, São Paulo 05503-900, BrazilAntibody-based passive immunotherapy has been used effectively in the treatment and prophylaxis of infectious diseases. Outbreaks of emerging viral infections from arthropod-borne viruses (arboviruses) represent a global public health problem due to their rapid spread, urging measures and the treatment of infected individuals to combat them. Preparedness in advances in developing antivirals and relevant epidemiological studies protect us from damage and losses. Immunotherapy based on monoclonal antibodies (mAbs) has been shown to be very specific in combating infectious diseases and various other illnesses. Recent advances in mAb discovery techniques have allowed the development and approval of a wide number of therapeutic mAbs. This review focuses on the technological approaches available to select neutralizing mAbs for emerging arbovirus infections and the next-generation strategies to obtain highly effective and potent mAbs. The characteristics of mAbs developed as prophylactic and therapeutic antiviral agents for dengue, Zika, chikungunya, West Nile and tick-borne encephalitis virus are presented, as well as the protective effect demonstrated in animal model studies.https://www.mdpi.com/1999-4915/15/11/2177arbovirusmonoclonal antibodyflavivirusalphavirusneutralizing antibodyantibody discovery |
| spellingShingle | Leonardo F. Ormundo Carolina T. Barreto Lilian R. Tsuruta Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus Infections Viruses arbovirus monoclonal antibody flavivirus alphavirus neutralizing antibody antibody discovery |
| title | Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus Infections |
| title_full | Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus Infections |
| title_fullStr | Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus Infections |
| title_full_unstemmed | Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus Infections |
| title_short | Development of Therapeutic Monoclonal Antibodies for Emerging Arbovirus Infections |
| title_sort | development of therapeutic monoclonal antibodies for emerging arbovirus infections |
| topic | arbovirus monoclonal antibody flavivirus alphavirus neutralizing antibody antibody discovery |
| url | https://www.mdpi.com/1999-4915/15/11/2177 |
| work_keys_str_mv | AT leonardoformundo developmentoftherapeuticmonoclonalantibodiesforemergingarbovirusinfections AT carolinatbarreto developmentoftherapeuticmonoclonalantibodiesforemergingarbovirusinfections AT lilianrtsuruta developmentoftherapeuticmonoclonalantibodiesforemergingarbovirusinfections |