Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug Target
Cytochrome <i>bd</i> is a triheme copper-free terminal oxidase in membrane respiratory chains of prokaryotes. This unique molecular machine couples electron transfer from quinol to O<sub>2</sub> with the generation of a proton motive force without proton pumping. Apart from e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/6/3166 |
| _version_ | 1797470876131655680 |
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| author | Thorsten Friedrich Daniel Wohlwend Vitaliy B. Borisov |
| author_facet | Thorsten Friedrich Daniel Wohlwend Vitaliy B. Borisov |
| author_sort | Thorsten Friedrich |
| collection | DOAJ |
| description | Cytochrome <i>bd</i> is a triheme copper-free terminal oxidase in membrane respiratory chains of prokaryotes. This unique molecular machine couples electron transfer from quinol to O<sub>2</sub> with the generation of a proton motive force without proton pumping. Apart from energy conservation, the <i>bd</i> enzyme plays an additional key role in the microbial cell, being involved in the response to different environmental stressors. Cytochrome <i>bd</i> promotes virulence in a number of pathogenic species that makes it a suitable molecular drug target candidate. This review focuses on recent advances in understanding the structure of cytochrome <i>bd</i> and the development of its selective inhibitors. |
| first_indexed | 2024-03-09T19:42:08Z |
| format | Article |
| id | doaj.art-25504232ecc94e01b7de007f800919c0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:42:08Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-25504232ecc94e01b7de007f800919c02023-11-24T01:34:03ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01236316610.3390/ijms23063166Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug TargetThorsten Friedrich0Daniel Wohlwend1Vitaliy B. Borisov2Institut für Biochemie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, GermanyInstitut für Biochemie, Albert-Ludwigs-Universität Freiburg, D-79104 Freiburg, GermanyBelozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Leninskie Gory, 119991 Moscow, RussiaCytochrome <i>bd</i> is a triheme copper-free terminal oxidase in membrane respiratory chains of prokaryotes. This unique molecular machine couples electron transfer from quinol to O<sub>2</sub> with the generation of a proton motive force without proton pumping. Apart from energy conservation, the <i>bd</i> enzyme plays an additional key role in the microbial cell, being involved in the response to different environmental stressors. Cytochrome <i>bd</i> promotes virulence in a number of pathogenic species that makes it a suitable molecular drug target candidate. This review focuses on recent advances in understanding the structure of cytochrome <i>bd</i> and the development of its selective inhibitors.https://www.mdpi.com/1422-0067/23/6/3166molecular bioenergeticsinhibitionelectron transport chainmembrane proteinterminal oxidasecytochrome oxidase |
| spellingShingle | Thorsten Friedrich Daniel Wohlwend Vitaliy B. Borisov Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug Target International Journal of Molecular Sciences molecular bioenergetics inhibition electron transport chain membrane protein terminal oxidase cytochrome oxidase |
| title | Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug Target |
| title_full | Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug Target |
| title_fullStr | Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug Target |
| title_full_unstemmed | Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug Target |
| title_short | Recent Advances in Structural Studies of Cytochrome <i>bd</i> and Its Potential Application as a Drug Target |
| title_sort | recent advances in structural studies of cytochrome i bd i and its potential application as a drug target |
| topic | molecular bioenergetics inhibition electron transport chain membrane protein terminal oxidase cytochrome oxidase |
| url | https://www.mdpi.com/1422-0067/23/6/3166 |
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