Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis
The analysis of the etiological and pathogenetic mechanisms of formation steatosis and steatohepatitis of mixed genesis is presented. It is shown that alcohol remains one of the main etiopathogenetic factors in the development of the hepatic steatosis and steatohepatitis, the role of which is observ...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2014-11-01
|
| Series: | Gastroenterologìa |
| Subjects: | |
| Online Access: | http://gastro.zaslavsky.com.ua/article/view/82089 |
| _version_ | 1798025884863561728 |
|---|---|
| author | Yu.M. Stepanov |
| author_facet | Yu.M. Stepanov |
| author_sort | Yu.M. Stepanov |
| collection | DOAJ |
| description | The analysis of the etiological and pathogenetic mechanisms of formation steatosis and steatohepatitis of mixed genesis is presented. It is shown that alcohol remains one of the main etiopathogenetic factors in the development of the hepatic steatosis and steatohepatitis, the role of which is observed in 46–65 % patients. There are strong evidence confirming that the obesity and insulin resistance are the independent factors of progression of steatosis and steatohepatitis of alcoholic, non-alcoholic and mixed etiology. The simultaneous influence of several etiological factors leads to the immediate development of steatosis and steatohepatitis in 95 % patients. Many trigger factors can be considered as complementary factors of liver damage of mixed genesis. Common approaches to the diagnosis, treatment, and the main group of drugs for the correction of steatosis and steatohepatitis of mixed origin are presented. |
| first_indexed | 2024-04-11T18:26:07Z |
| format | Article |
| id | doaj.art-2551ff2848a94d0dbfcdeb9fb3bfeb25 |
| institution | Directory Open Access Journal |
| issn | 2308-2097 2518-7880 |
| language | English |
| last_indexed | 2024-04-11T18:26:07Z |
| publishDate | 2014-11-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Gastroenterologìa |
| spelling | doaj.art-2551ff2848a94d0dbfcdeb9fb3bfeb252022-12-22T04:09:36ZengZaslavsky O.Yu.Gastroenterologìa2308-20972518-78802014-11-01484.5413614210.22141/2308-2097.4.54.2014.8208982089Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed GenesisYu.M. Stepanov0SI «Institute of Gastroenterology of NAMS of Ukraine», Dnipropetrovsk, UkraineThe analysis of the etiological and pathogenetic mechanisms of formation steatosis and steatohepatitis of mixed genesis is presented. It is shown that alcohol remains one of the main etiopathogenetic factors in the development of the hepatic steatosis and steatohepatitis, the role of which is observed in 46–65 % patients. There are strong evidence confirming that the obesity and insulin resistance are the independent factors of progression of steatosis and steatohepatitis of alcoholic, non-alcoholic and mixed etiology. The simultaneous influence of several etiological factors leads to the immediate development of steatosis and steatohepatitis in 95 % patients. Many trigger factors can be considered as complementary factors of liver damage of mixed genesis. Common approaches to the diagnosis, treatment, and the main group of drugs for the correction of steatosis and steatohepatitis of mixed origin are presented.http://gastro.zaslavsky.com.ua/article/view/82089steatosissteatohepatitisalcoholobesityinsulin resistanceetiopathogenesisdiagnosiscorrection |
| spellingShingle | Yu.M. Stepanov Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis Gastroenterologìa steatosis steatohepatitis alcohol obesity insulin resistance etiopathogenesis diagnosis correction |
| title | Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis |
| title_full | Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis |
| title_fullStr | Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis |
| title_full_unstemmed | Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis |
| title_short | Hepatic Steatosis and Steatohepatitis Is the Inevitability of Mixed Genesis |
| title_sort | hepatic steatosis and steatohepatitis is the inevitability of mixed genesis |
| topic | steatosis steatohepatitis alcohol obesity insulin resistance etiopathogenesis diagnosis correction |
| url | http://gastro.zaslavsky.com.ua/article/view/82089 |
| work_keys_str_mv | AT yumstepanov hepaticsteatosisandsteatohepatitisistheinevitabilityofmixedgenesis |