Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis
<p>Abstract</p> <p>Backround</p> <p>The emergence of <it>Mycobacterium tuberculosis </it>strains resistant to antituberculosis agents has recently received increased attention owing largely to the dramatic outbreaks of multi drug resistance tuberculosis (MDR...
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BMC
2002-12-01
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Series: | Annals of Clinical Microbiology and Antimicrobials |
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Online Access: | http://www.ann-clinmicrob.com/content/1/1/6 |
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author | Oymak Sema F Gulmez Inci Tor Meltem Altın Remzi Kart Levent Atmaca Hulusi M Erdem Funda |
author_facet | Oymak Sema F Gulmez Inci Tor Meltem Altın Remzi Kart Levent Atmaca Hulusi M Erdem Funda |
author_sort | Oymak Sema F |
collection | DOAJ |
description | <p>Abstract</p> <p>Backround</p> <p>The emergence of <it>Mycobacterium tuberculosis </it>strains resistant to antituberculosis agents has recently received increased attention owing largely to the dramatic outbreaks of multi drug resistance tuberculosis (MDR-TB).</p> <p>Methods</p> <p>Patients residing in Zonguldak and Kayseri provinces of Turkey with, pulmonary tuberculosis diagnosed between 1972 and 1999 were retrospectively identified. Drug susceptibility tests had been performed for isoniazid (INH), rifampin (RIF), streptomycin (SM), ethambutol (EMB) and thiacetasone (TH) after isolation by using the resistance proportion method.</p> <p>Results</p> <p>Total 3718 patients were retrospectively studied. In 1972–1981, resistance rates for to SM and INH were found to be 14.8% and 9.8% respectively (n: 2172). In 1982–1991 period, resistance rates for INH, SM, RIF, EMB and TH were 14.2%, 14.4%, 10.5%, 2.7% and 2.9% (n: 683), while in 1992–1999 period 14.4%, 21.1%, 10.6%, 2.4% and 3.7% respectively (n: 863). Resistance rates were highest for SM and INH in three periods. MDR-TB patients constituted 7.3% and 6.6% of 1982–1991 and 1992–1999 periods (p > 0.05).</p> <p>Conclusion</p> <p>This study demonstrates the importance of resistance rates for TB. Continued surveillance and immediate therapeutic decisions should be undertaken in order to prevent the dissemination of such resistant strains.</p> |
first_indexed | 2024-04-13T10:30:15Z |
format | Article |
id | doaj.art-255439033fc8425690235d52342fa549 |
institution | Directory Open Access Journal |
issn | 1476-0711 |
language | English |
last_indexed | 2024-04-13T10:30:15Z |
publishDate | 2002-12-01 |
publisher | BMC |
record_format | Article |
series | Annals of Clinical Microbiology and Antimicrobials |
spelling | doaj.art-255439033fc8425690235d52342fa5492022-12-22T02:50:12ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112002-12-0111610.1186/1476-0711-1-6Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysisOymak Sema FGulmez InciTor MeltemAltın RemziKart LeventAtmaca Hulusi MErdem Funda<p>Abstract</p> <p>Backround</p> <p>The emergence of <it>Mycobacterium tuberculosis </it>strains resistant to antituberculosis agents has recently received increased attention owing largely to the dramatic outbreaks of multi drug resistance tuberculosis (MDR-TB).</p> <p>Methods</p> <p>Patients residing in Zonguldak and Kayseri provinces of Turkey with, pulmonary tuberculosis diagnosed between 1972 and 1999 were retrospectively identified. Drug susceptibility tests had been performed for isoniazid (INH), rifampin (RIF), streptomycin (SM), ethambutol (EMB) and thiacetasone (TH) after isolation by using the resistance proportion method.</p> <p>Results</p> <p>Total 3718 patients were retrospectively studied. In 1972–1981, resistance rates for to SM and INH were found to be 14.8% and 9.8% respectively (n: 2172). In 1982–1991 period, resistance rates for INH, SM, RIF, EMB and TH were 14.2%, 14.4%, 10.5%, 2.7% and 2.9% (n: 683), while in 1992–1999 period 14.4%, 21.1%, 10.6%, 2.4% and 3.7% respectively (n: 863). Resistance rates were highest for SM and INH in three periods. MDR-TB patients constituted 7.3% and 6.6% of 1982–1991 and 1992–1999 periods (p > 0.05).</p> <p>Conclusion</p> <p>This study demonstrates the importance of resistance rates for TB. Continued surveillance and immediate therapeutic decisions should be undertaken in order to prevent the dissemination of such resistant strains.</p>http://www.ann-clinmicrob.com/content/1/1/6TuberculosisDrug resistanceEpidemiologyTurkey |
spellingShingle | Oymak Sema F Gulmez Inci Tor Meltem Altın Remzi Kart Levent Atmaca Hulusi M Erdem Funda Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis Annals of Clinical Microbiology and Antimicrobials Tuberculosis Drug resistance Epidemiology Turkey |
title | Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis |
title_full | Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis |
title_fullStr | Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis |
title_full_unstemmed | Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis |
title_short | Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis |
title_sort | antituberculosis drug resistance patterns in two regions of turkey a retrospective analysis |
topic | Tuberculosis Drug resistance Epidemiology Turkey |
url | http://www.ann-clinmicrob.com/content/1/1/6 |
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