Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka
<h4>Background</h4> There are limited data regarding the safety and immunogenicity of the Sinopharm/BBIBP-CorV vaccine in pregnancy. Therefore, we sought to investigate the antibody responses and maternal and fetal adverse events following this vaccine in pregnant mothers in Sri Lanka. &...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLOS Global Public Health |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022122/?tool=EBI |
| _version_ | 1827830462987370496 |
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| author | Chandima Jeewandara K. A. Chintha S. Jayampathi Thushali Ranasinghe Inoka Sepali Aberathna Banuri Gunasekara Saubhagya Danasekara Thashmi Nimasha Heshan Kuruppu Osanda Dissanayake Nayanathara Gamalath Dinithi Ekanayake Jewantha Jayamali Gayasha Somathilake Dinuka Guruge Ruwan Wijayamuni Achala Kamaladasa Graham S. Ogg Gathsaurie Neelika Malavige |
| author_facet | Chandima Jeewandara K. A. Chintha S. Jayampathi Thushali Ranasinghe Inoka Sepali Aberathna Banuri Gunasekara Saubhagya Danasekara Thashmi Nimasha Heshan Kuruppu Osanda Dissanayake Nayanathara Gamalath Dinithi Ekanayake Jewantha Jayamali Gayasha Somathilake Dinuka Guruge Ruwan Wijayamuni Achala Kamaladasa Graham S. Ogg Gathsaurie Neelika Malavige |
| author_sort | Chandima Jeewandara |
| collection | DOAJ |
| description | <h4>Background</h4> There are limited data regarding the safety and immunogenicity of the Sinopharm/BBIBP-CorV vaccine in pregnancy. Therefore, we sought to investigate the antibody responses and maternal and fetal adverse events following this vaccine in pregnant mothers in Sri Lanka. <h4>Methods and findings</h4> SARS-CoV-2 receptor binding domain (RBD) specific total antibodies and ACE2 blocking antibodies were measured by ELISA in pregnant mothers (n = 94) who received the vaccine in the first (n = 2), second (n = 57) and third (n = 33) trimester of pregnancy. Data regarding adverse events and fetal and maternal outcomes were obtained from the women once they delivered. No adverse maternal or fetal complications reported such as miscarriage, thrombotic events, hypertensive disorders, fetal death, preterm delivery, or congenital anomalies were reported. 58/94 (61.7%) had RBD binding antibodies and were found to be seropositive at the time of recruitment. All women seroconverted after the second dose and 31/36 previously uninfected women and 57/58 previously infected women gave a positive response to ACE2 blocking antibodies. The RBD binding antibody levels (p = 0.0002) and ACE2 blocking antibodies (p<0.0001) were significantly higher in previously infected individuals post-second dose compared to uninfected individuals. <h4>Conclusions</h4> The Sinopharm/ BBIBP-CorV vaccine appeared safe and induced high seroconversion rates and ACE2 blocking antibodies in pregnant mothers in the second and third trimester in pregnancy. However, the RBD binding antibodies and ACE2 blocking antibodies post-second dose were significantly higher in previously infected pregnant mothers post-second dose, suggesting that two doses of the vaccine are likely to be less immunogenic in previously unexposed individuals. |
| first_indexed | 2024-03-12T04:29:31Z |
| format | Article |
| id | doaj.art-255578bcfabd4fa59246f819e9db34ee |
| institution | Directory Open Access Journal |
| issn | 2767-3375 |
| language | English |
| last_indexed | 2024-03-12T04:29:31Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLOS Global Public Health |
| spelling | doaj.art-255578bcfabd4fa59246f819e9db34ee2023-09-03T10:09:07ZengPublic Library of Science (PLoS)PLOS Global Public Health2767-33752022-01-0127Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri LankaChandima JeewandaraK. A. Chintha S. JayampathiThushali RanasingheInoka Sepali AberathnaBanuri GunasekaraSaubhagya DanasekaraThashmi NimashaHeshan KuruppuOsanda DissanayakeNayanathara GamalathDinithi EkanayakeJewantha JayamaliGayasha SomathilakeDinuka GurugeRuwan WijayamuniAchala KamaladasaGraham S. OggGathsaurie Neelika Malavige<h4>Background</h4> There are limited data regarding the safety and immunogenicity of the Sinopharm/BBIBP-CorV vaccine in pregnancy. Therefore, we sought to investigate the antibody responses and maternal and fetal adverse events following this vaccine in pregnant mothers in Sri Lanka. <h4>Methods and findings</h4> SARS-CoV-2 receptor binding domain (RBD) specific total antibodies and ACE2 blocking antibodies were measured by ELISA in pregnant mothers (n = 94) who received the vaccine in the first (n = 2), second (n = 57) and third (n = 33) trimester of pregnancy. Data regarding adverse events and fetal and maternal outcomes were obtained from the women once they delivered. No adverse maternal or fetal complications reported such as miscarriage, thrombotic events, hypertensive disorders, fetal death, preterm delivery, or congenital anomalies were reported. 58/94 (61.7%) had RBD binding antibodies and were found to be seropositive at the time of recruitment. All women seroconverted after the second dose and 31/36 previously uninfected women and 57/58 previously infected women gave a positive response to ACE2 blocking antibodies. The RBD binding antibody levels (p = 0.0002) and ACE2 blocking antibodies (p<0.0001) were significantly higher in previously infected individuals post-second dose compared to uninfected individuals. <h4>Conclusions</h4> The Sinopharm/ BBIBP-CorV vaccine appeared safe and induced high seroconversion rates and ACE2 blocking antibodies in pregnant mothers in the second and third trimester in pregnancy. However, the RBD binding antibodies and ACE2 blocking antibodies post-second dose were significantly higher in previously infected pregnant mothers post-second dose, suggesting that two doses of the vaccine are likely to be less immunogenic in previously unexposed individuals.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022122/?tool=EBI |
| spellingShingle | Chandima Jeewandara K. A. Chintha S. Jayampathi Thushali Ranasinghe Inoka Sepali Aberathna Banuri Gunasekara Saubhagya Danasekara Thashmi Nimasha Heshan Kuruppu Osanda Dissanayake Nayanathara Gamalath Dinithi Ekanayake Jewantha Jayamali Gayasha Somathilake Dinuka Guruge Ruwan Wijayamuni Achala Kamaladasa Graham S. Ogg Gathsaurie Neelika Malavige Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka PLOS Global Public Health |
| title | Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka |
| title_full | Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka |
| title_fullStr | Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka |
| title_full_unstemmed | Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka |
| title_short | Antibody responses to Sinopharm/BBIBP-CorV in pregnant mothers in Sri Lanka |
| title_sort | antibody responses to sinopharm bbibp corv in pregnant mothers in sri lanka |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022122/?tool=EBI |
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