Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study
Summary: Background: There were no reports on the associations of aortic arch calcification (AAC) measured by chest X-ray with all-cause mortality and cardiovascular disease (CVD) in older general population. Moreover, previous studies of hemodialysis patients showed that AAC was correlated with le...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | The Lancet Regional Health. Western Pacific |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S266660652200075X |
| _version_ | 1818029594805010432 |
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| author | Wen Bo Tian Wei Sen Zhang Chao Qiang Jiang Xiang Yi Liu Ya Li Jin Tai Hing Lam Kar Keung Cheng Lin Xu |
| author_facet | Wen Bo Tian Wei Sen Zhang Chao Qiang Jiang Xiang Yi Liu Ya Li Jin Tai Hing Lam Kar Keung Cheng Lin Xu |
| author_sort | Wen Bo Tian |
| collection | DOAJ |
| description | Summary: Background: There were no reports on the associations of aortic arch calcification (AAC) measured by chest X-ray with all-cause mortality and cardiovascular disease (CVD) in older general population. Moreover, previous studies of hemodialysis patients showed that AAC was correlated with left ventricular hypertrophy (LVH) and predicted CVD jointly. Whether the effects remained in the general population is unknown. We examined the associations of AAC with all-cause mortality and CVD in general population and the risk associated with the coexistence of AAC and LVH. Methods: Presence and severity (grades 0-2) of AAC were measured by chest X-ray, and LVH was identified by 12-lead electrocardiogram in 27,166 Chinese aged 50+ years free of CVD from Guangzhou Biobank Cohort Study. Multivariate Cox regressions were used to examine associations of AAC and LVH with outcomes. Findings: During an average follow-up of 14·3 years, 5,350 deaths and 4,012 CVD occurred. Compared to those without AAC at baseline, those with AAC had higher risks of all-cause mortality (HR 1·24, 95% CI 1·17-1·31) and CVD (HR 1·22, 95% CI 1·14-1·30), with dose-response relationship (P ≤ 0·001). Furthermore, those with coexistence of AAC and LVH had higher risks of all-cause mortality (HR 1·72, 95% CI 1·37-2·15) and CVD (HR 1·80, 95% CI 1·40-2·32) than those without AAC and LVH. Interpretation: As chest X-ray has been performed commonly for health screening and in hospital patients when first admitted, AAC measured by chest X-ray can be further applied to assist cardiovascular risk stratification in the community and clinical settings. Funding: The Natural Science Foundation of China (No. 81941019). |
| first_indexed | 2024-12-10T05:22:11Z |
| format | Article |
| id | doaj.art-2557b8f6d0104ae58861394a8b882071 |
| institution | Directory Open Access Journal |
| issn | 2666-6065 |
| language | English |
| last_indexed | 2024-12-10T05:22:11Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Western Pacific |
| spelling | doaj.art-2557b8f6d0104ae58861394a8b8820712022-12-22T02:00:46ZengElsevierThe Lancet Regional Health. Western Pacific2666-60652022-06-0123100460Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort StudyWen Bo Tian0Wei Sen Zhang1Chao Qiang Jiang2Xiang Yi Liu3Ya Li Jin4Tai Hing Lam5Kar Keung Cheng6Lin Xu7School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, ChinaGuangzhou Twelfth People's Hospital, Guangzhou 510620, China; Corresponding author.Guangzhou Twelfth People's Hospital, Guangzhou 510620, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou 510403, ChinaGuangzhou Twelfth People's Hospital, Guangzhou 510620, ChinaGuangzhou Twelfth People's Hospital, Guangzhou 510620, China; School of Public Health, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong, China; Corresponding authors at: School of Public Health, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong, China.Institute of Applied Health Research, University of Birmingham, Birmingham, UKSchool of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, Guangzhou, Guangdong 510080, China; School of Public Health, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong, China; Corresponding authors at: School of Public Health, The University of Hong Kong, 7 Sassoon Road, Pokfulam, Hong Kong, China.Summary: Background: There were no reports on the associations of aortic arch calcification (AAC) measured by chest X-ray with all-cause mortality and cardiovascular disease (CVD) in older general population. Moreover, previous studies of hemodialysis patients showed that AAC was correlated with left ventricular hypertrophy (LVH) and predicted CVD jointly. Whether the effects remained in the general population is unknown. We examined the associations of AAC with all-cause mortality and CVD in general population and the risk associated with the coexistence of AAC and LVH. Methods: Presence and severity (grades 0-2) of AAC were measured by chest X-ray, and LVH was identified by 12-lead electrocardiogram in 27,166 Chinese aged 50+ years free of CVD from Guangzhou Biobank Cohort Study. Multivariate Cox regressions were used to examine associations of AAC and LVH with outcomes. Findings: During an average follow-up of 14·3 years, 5,350 deaths and 4,012 CVD occurred. Compared to those without AAC at baseline, those with AAC had higher risks of all-cause mortality (HR 1·24, 95% CI 1·17-1·31) and CVD (HR 1·22, 95% CI 1·14-1·30), with dose-response relationship (P ≤ 0·001). Furthermore, those with coexistence of AAC and LVH had higher risks of all-cause mortality (HR 1·72, 95% CI 1·37-2·15) and CVD (HR 1·80, 95% CI 1·40-2·32) than those without AAC and LVH. Interpretation: As chest X-ray has been performed commonly for health screening and in hospital patients when first admitted, AAC measured by chest X-ray can be further applied to assist cardiovascular risk stratification in the community and clinical settings. Funding: The Natural Science Foundation of China (No. 81941019).http://www.sciencedirect.com/science/article/pii/S266660652200075XCardiovascular diseaseMortalityRisk factorAortic archVascular calcification |
| spellingShingle | Wen Bo Tian Wei Sen Zhang Chao Qiang Jiang Xiang Yi Liu Ya Li Jin Tai Hing Lam Kar Keung Cheng Lin Xu Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study The Lancet Regional Health. Western Pacific Cardiovascular disease Mortality Risk factor Aortic arch Vascular calcification |
| title | Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study |
| title_full | Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study |
| title_fullStr | Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study |
| title_full_unstemmed | Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study |
| title_short | Aortic arch calcification and risk of all-cause mortality and cardiovascular disease: The Guangzhou Biobank Cohort Study |
| title_sort | aortic arch calcification and risk of all cause mortality and cardiovascular disease the guangzhou biobank cohort study |
| topic | Cardiovascular disease Mortality Risk factor Aortic arch Vascular calcification |
| url | http://www.sciencedirect.com/science/article/pii/S266660652200075X |
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