Trials and Tribulations with VH Replacement

Trials and Tribulations with VH Replacement

VH replacement is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VH replacement, its developmental timing and its potential bi...

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Bibliographic Details
Main Authors: Wenzhao eMeng, Sahana eJayaraman, Zhang eBochao, Gregory W. Schwartz, Robert eDaber, Uri eHershberg, Alfred eGarfall, Christopher S Carlson, Eline T. Luning Prak
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-01-01
Series:Frontiers in Immunology
Subjects:
V(D)J Recombination
receptor editing
high throughput sequencing
VH replacement
CDR3H
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00010/full

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