Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor
Immunotherapy of malignant tumors has become a hot spot in the field of cancer research and treatment, bringing new hope to patients with advanced cancer. Activation of molecular programmer death protein-1 and T lymphocyte-associated antigen 4-related signaling pathways at the immunological checkpoi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2019-10-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.04 |
| _version_ | 1811267859149488128 |
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| author | Xiaoxiao GUO Hanping WANG Jiaxin ZHOU Lian DUAN Yue LI Xiaoyan SI Li ZHANG Ligang FANG Li ZHANG |
| author_facet | Xiaoxiao GUO Hanping WANG Jiaxin ZHOU Lian DUAN Yue LI Xiaoyan SI Li ZHANG Ligang FANG Li ZHANG |
| author_sort | Xiaoxiao GUO |
| collection | DOAJ |
| description | Immunotherapy of malignant tumors has become a hot spot in the field of cancer research and treatment, bringing new hope to patients with advanced cancer. Activation of molecular programmer death protein-1 and T lymphocyte-associated antigen 4-related signaling pathways at the immunological checkpoint can inhibit T lymphocyte activation and thereby block the inflammatory response. Tumor cells achieve immune escape by activating the molecular pathways associated with immune checkpoints. The immune checkpoint inhibitor can wake up T lymphocytes and enhance the body's clearance of tumor cells. However, the role of immune checkpoint inhibitors is not specific to tumor cells, and it can cause side effects of multiple systems including the cardiovascular system while killing tumor cells. We will summarize the relevant cardiac side effects and give advice on how to manage it. |
| first_indexed | 2024-04-12T21:10:14Z |
| format | Article |
| id | doaj.art-255931a050b04ed3ae9fe8e95e7c7cfd |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-04-12T21:10:14Z |
| publishDate | 2019-10-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-255931a050b04ed3ae9fe8e95e7c7cfd2022-12-22T03:16:36ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872019-10-01221062763210.3779/j.issn.1009-3419.2019.10.04Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint InhibitorXiaoxiao GUO0Hanping WANG1Jiaxin ZHOU2Lian DUAN3Yue LI4Xiaoyan SI5Li ZHANG6Ligang FANG7Li ZHANG8Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Rheumatism and Immunology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Digestive Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, ChinaImmunotherapy of malignant tumors has become a hot spot in the field of cancer research and treatment, bringing new hope to patients with advanced cancer. Activation of molecular programmer death protein-1 and T lymphocyte-associated antigen 4-related signaling pathways at the immunological checkpoint can inhibit T lymphocyte activation and thereby block the inflammatory response. Tumor cells achieve immune escape by activating the molecular pathways associated with immune checkpoints. The immune checkpoint inhibitor can wake up T lymphocytes and enhance the body's clearance of tumor cells. However, the role of immune checkpoint inhibitors is not specific to tumor cells, and it can cause side effects of multiple systems including the cardiovascular system while killing tumor cells. We will summarize the relevant cardiac side effects and give advice on how to manage it.http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.04Immune checkpoint inhibitorImmunotherapy-related toxicitiesMyocarditisCardiovascular toxicities |
| spellingShingle | Xiaoxiao GUO Hanping WANG Jiaxin ZHOU Lian DUAN Yue LI Xiaoyan SI Li ZHANG Ligang FANG Li ZHANG Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor Chinese Journal of Lung Cancer Immune checkpoint inhibitor Immunotherapy-related toxicities Myocarditis Cardiovascular toxicities |
| title | Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor |
| title_full | Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor |
| title_fullStr | Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor |
| title_full_unstemmed | Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor |
| title_short | Clinical Diagnosis and Treatment Recommendations for Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor |
| title_sort | clinical diagnosis and treatment recommendations for cardiac adverse reactions related to immune checkpoint inhibitor |
| topic | Immune checkpoint inhibitor Immunotherapy-related toxicities Myocarditis Cardiovascular toxicities |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2019.10.04 |
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