Smart bioadhesives for wound healing and closure
The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing, wireless communication, and on-demand treatment capabilities. Bioadhesives with bio-inspired structures and chemicals have s...
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-01-01
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| Series: | Bioactive Materials |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22001906 |
| _version_ | 1797204857554206720 |
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| author | Jia Zhu Honglei Zhou Ethan Michael Gerhard Senhao Zhang Flor Itzel Parra Rodríguez Taisong Pan Hongbo Yang Yuan Lin Jian Yang Huanyu Cheng |
| author_facet | Jia Zhu Honglei Zhou Ethan Michael Gerhard Senhao Zhang Flor Itzel Parra Rodríguez Taisong Pan Hongbo Yang Yuan Lin Jian Yang Huanyu Cheng |
| author_sort | Jia Zhu |
| collection | DOAJ |
| description | The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing, wireless communication, and on-demand treatment capabilities. Bioadhesives with bio-inspired structures and chemicals have shown unprecedented adhesion strengths, as well as tunable optical, electrical, and bio-dissolvable properties. Accelerated wound healing has been achieved via directly released antibacterial and growth factors, material or drug-induced host immune responses, and delivery of curative cells. Most recently, the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives, allowing real-time sensing of the physiological conditions (e.g., pH, temperature, uric acid, glucose, and cytokine) with iterative feedback for drastically enhanced, stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged inflammation. Despite rapid advances in the burgeoning field, challenges still exist in the design and fabrication of integrated systems, particularly for chronic wounds, presenting significant opportunities for the future development of next-generation smart materials and systems. |
| first_indexed | 2024-04-11T20:32:14Z |
| format | Article |
| id | doaj.art-25595f0be1364ef3b744d79b9bb6e4e4 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:41:53Z |
| publishDate | 2023-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-25595f0be1364ef3b744d79b9bb6e4e42024-04-16T15:31:52ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2023-01-0119360375Smart bioadhesives for wound healing and closureJia Zhu0Honglei Zhou1Ethan Michael Gerhard2Senhao Zhang3Flor Itzel Parra Rodríguez4Taisong Pan5Hongbo Yang6Yuan Lin7Jian Yang8Huanyu Cheng9Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USAAML, Department of Engineering Mechanics, Tsinghua University, Beijing, 100084, China; Institute of Flexible Electronics Technology of THU, Zhejiang, Jiaxing, 314000, ChinaDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USADepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, 215011, PR ChinaDepartment of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USASchool of Materials and Energy, State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, PR ChinaSuzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou, 215011, PR ChinaSchool of Materials and Energy, State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, PR China; Corresponding author. School of Materials and Energy, State Key Laboratory of Electronic Thin Films and Integrated Devices, University of Electronic Science and Technology of China, Chengdu, 610054, PR China.Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA; Corresponding author. Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA; Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA; Materials Research Institute, The Pennsylvania State University, University Park, PA, 16802, USA; Corresponding author. Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, 16802, USA.The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion, antibacterial effect, real-time sensing, wireless communication, and on-demand treatment capabilities. Bioadhesives with bio-inspired structures and chemicals have shown unprecedented adhesion strengths, as well as tunable optical, electrical, and bio-dissolvable properties. Accelerated wound healing has been achieved via directly released antibacterial and growth factors, material or drug-induced host immune responses, and delivery of curative cells. Most recently, the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives, allowing real-time sensing of the physiological conditions (e.g., pH, temperature, uric acid, glucose, and cytokine) with iterative feedback for drastically enhanced, stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged inflammation. Despite rapid advances in the burgeoning field, challenges still exist in the design and fabrication of integrated systems, particularly for chronic wounds, presenting significant opportunities for the future development of next-generation smart materials and systems.http://www.sciencedirect.com/science/article/pii/S2452199X22001906Smart bioadhesivesImmunomodulatory bioadhesivesMechanically/electrically active bioadhesivesClosed-loop systemOn-demand treatmentsWound healing and closure |
| spellingShingle | Jia Zhu Honglei Zhou Ethan Michael Gerhard Senhao Zhang Flor Itzel Parra Rodríguez Taisong Pan Hongbo Yang Yuan Lin Jian Yang Huanyu Cheng Smart bioadhesives for wound healing and closure Bioactive Materials Smart bioadhesives Immunomodulatory bioadhesives Mechanically/electrically active bioadhesives Closed-loop system On-demand treatments Wound healing and closure |
| title | Smart bioadhesives for wound healing and closure |
| title_full | Smart bioadhesives for wound healing and closure |
| title_fullStr | Smart bioadhesives for wound healing and closure |
| title_full_unstemmed | Smart bioadhesives for wound healing and closure |
| title_short | Smart bioadhesives for wound healing and closure |
| title_sort | smart bioadhesives for wound healing and closure |
| topic | Smart bioadhesives Immunomodulatory bioadhesives Mechanically/electrically active bioadhesives Closed-loop system On-demand treatments Wound healing and closure |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22001906 |
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