Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, Nigeria
Co-infection of Human Immunodeficiency Virus/Acquired Immune Disease Syndrome (HIV/AIDS) with hepatitis is linked with amplified morbidity and mortality. This study was to investigate the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) among patients on hig...
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Deccan College of Medical Sciences
2018-01-01
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| Series: | Journal of Medical and Allied Sciences |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=279731 |
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| author | Paul Columba Inyang-Etoh Offid Abosede Obi Mfoniso Iniobong Udonkang |
| author_facet | Paul Columba Inyang-Etoh Offid Abosede Obi Mfoniso Iniobong Udonkang |
| author_sort | Paul Columba Inyang-Etoh |
| collection | DOAJ |
| description | Co-infection of Human Immunodeficiency Virus/Acquired Immune Disease Syndrome (HIV/AIDS) with hepatitis is linked with amplified morbidity and mortality. This study was to investigate the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) among patients on highly active antiretroviral drug therapy (HAART). A total of 200 subjects currently on HAART and 50 non-HIV positive individuals (control subjects) aged 10-75 years were recruited for the study. Hepatitis B surface antigen and hepatitis C viral antibodies were screened with ACON test strip while HDV was screened with human hepatitis D virus ELISA kit. Demographic data of subjects were obtained with questionnaires. Determination of the CD4 counts was done using the Cytoflow counter. Among the test subjects, prevalence of HBV infection was 16(8%), HCV was 6(3%), mixed infection with HBV and HCV was 2(1%), and HDV was 0(0%). Among the control subjects, infection with HBV was 6(12%), 4(8%) for HCV and none for HDV or mixed infection. There was no statistically significant difference (p=0.491). Males had a higher occurrence of HBV infection 9(11.4%) and HCV infection 4(5.1%) than the females who had 7(5.8%) for HBV and 2(1.6%) for HCV, but this was not statistically significant (p=0.0879). Subjects with CD4 count range of 1401-1600 had the highest occurrence 1(20%) for HBV and 1201-1400 range for HCV 1(8.3%) but the difference was not statistically significant (p=0.504). In conclusion, infection with HBV and HCV is widespread among patients on HAART and routine screening is advocated for efficient management of the disease. [J Med Allied Sci 2018; 8(1.000): 17-21] |
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| language | English |
| last_indexed | 2024-12-13T04:32:25Z |
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| publisher | Deccan College of Medical Sciences |
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| series | Journal of Medical and Allied Sciences |
| spelling | doaj.art-255b736daf794aaf8edb8e56679809a12022-12-21T23:59:30ZengDeccan College of Medical SciencesJournal of Medical and Allied Sciences2231-16962231-170X2018-01-0181172110.5455/jmas.279731279731Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, NigeriaPaul Columba Inyang-Etoh0Offid Abosede Obi1Mfoniso Iniobong Udonkang2Medical Laboratory Science Department, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, P. M. B. 1115, Calabar, Cross River State, Nigeria Medical Laboratory Science Department, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, P. M. B. 1115, Calabar, Cross River State, Nigeria Medical Laboratory Science Department, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, P. M. B. 1115, Calabar, Cross River State, Nigeria.Co-infection of Human Immunodeficiency Virus/Acquired Immune Disease Syndrome (HIV/AIDS) with hepatitis is linked with amplified morbidity and mortality. This study was to investigate the prevalence of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) among patients on highly active antiretroviral drug therapy (HAART). A total of 200 subjects currently on HAART and 50 non-HIV positive individuals (control subjects) aged 10-75 years were recruited for the study. Hepatitis B surface antigen and hepatitis C viral antibodies were screened with ACON test strip while HDV was screened with human hepatitis D virus ELISA kit. Demographic data of subjects were obtained with questionnaires. Determination of the CD4 counts was done using the Cytoflow counter. Among the test subjects, prevalence of HBV infection was 16(8%), HCV was 6(3%), mixed infection with HBV and HCV was 2(1%), and HDV was 0(0%). Among the control subjects, infection with HBV was 6(12%), 4(8%) for HCV and none for HDV or mixed infection. There was no statistically significant difference (p=0.491). Males had a higher occurrence of HBV infection 9(11.4%) and HCV infection 4(5.1%) than the females who had 7(5.8%) for HBV and 2(1.6%) for HCV, but this was not statistically significant (p=0.0879). Subjects with CD4 count range of 1401-1600 had the highest occurrence 1(20%) for HBV and 1201-1400 range for HCV 1(8.3%) but the difference was not statistically significant (p=0.504). In conclusion, infection with HBV and HCV is widespread among patients on HAART and routine screening is advocated for efficient management of the disease. [J Med Allied Sci 2018; 8(1.000): 17-21]http://www.ejmanager.com/fulltextpdf.php?mno=279731CalabarHAARTHBVHCVHDVPrevalence |
| spellingShingle | Paul Columba Inyang-Etoh Offid Abosede Obi Mfoniso Iniobong Udonkang Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, Nigeria Journal of Medical and Allied Sciences Calabar HAART HBV HCV HDV Prevalence |
| title | Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, Nigeria |
| title_full | Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, Nigeria |
| title_fullStr | Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, Nigeria |
| title_full_unstemmed | Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, Nigeria |
| title_short | Prevalence of hepatitis B, C and D among patients on highly active antiretroviral drug therapy (HAART) in Calabar metropolis, Nigeria |
| title_sort | prevalence of hepatitis b c and d among patients on highly active antiretroviral drug therapy haart in calabar metropolis nigeria |
| topic | Calabar HAART HBV HCV HDV Prevalence |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=279731 |
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