Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins
Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathologi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2012-06-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4409/1/2/168 |
| _version_ | 1797714410284777472 |
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| author | Thierry Arnould Patricia Renard Anaïs Wanet Kayleen Vannuvel Sébastien Michel Stéphane Demine |
| author_facet | Thierry Arnould Patricia Renard Anaïs Wanet Kayleen Vannuvel Sébastien Michel Stéphane Demine |
| author_sort | Thierry Arnould |
| collection | DOAJ |
| description | Macroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion. |
| first_indexed | 2024-03-12T07:51:28Z |
| format | Article |
| id | doaj.art-255d259c6add4bb68cb3d8a591ac2896 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T07:51:28Z |
| publishDate | 2012-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-255d259c6add4bb68cb3d8a591ac28962023-09-02T20:30:57ZengMDPI AGCells2073-44092012-06-011216820310.3390/cells1020168Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of ProteinsThierry ArnouldPatricia RenardAnaïs WanetKayleen VannuvelSébastien MichelStéphane DemineMacroautophagy has important physiological roles and its cytoprotective or detrimental function is compromised in various diseases such as many cancers and metabolic diseases. However, the importance of autophagy for cell responses has also been demonstrated in many other physiological and pathological situations. In this review, we discuss some of the recently discovered mechanisms involved in specific and unspecific autophagy related to mitochondrial dysfunction and organelle degradation, lipid metabolism and lipophagy as well as recent findings and evidence that link autophagy to unconventional protein secretion.http://www.mdpi.com/2073-4409/1/2/168mitophagylipophagyspecific autophagyorganelle dysfunctiontriglyceride accumulationprotein secretion |
| spellingShingle | Thierry Arnould Patricia Renard Anaïs Wanet Kayleen Vannuvel Sébastien Michel Stéphane Demine Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins Cells mitophagy lipophagy specific autophagy organelle dysfunction triglyceride accumulation protein secretion |
| title | Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins |
| title_full | Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins |
| title_fullStr | Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins |
| title_full_unstemmed | Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins |
| title_short | Macroautophagy and Cell Responses Related to Mitochondrial Dysfunction, Lipid Metabolism and Unconventional Secretion of Proteins |
| title_sort | macroautophagy and cell responses related to mitochondrial dysfunction lipid metabolism and unconventional secretion of proteins |
| topic | mitophagy lipophagy specific autophagy organelle dysfunction triglyceride accumulation protein secretion |
| url | http://www.mdpi.com/2073-4409/1/2/168 |
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