Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2
Despite of contact restrictions, population mobility remains the main reason for the spread of SARS-CoV-2. The state of Baden-Württemberg (BW), Germany, approved a model study in Tübingen (TÜMOD) to evaluate how mandatory rapid diagnostic tests (RDT) could reduce transmission. Between 16 March and 2...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1159622/full |
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| author | Jule Ayran Carsten Köhler Le Thi Kieu Linh Le Thi Kieu Linh Gisela Schneider Srinivas Reddy Pallerla Florian Battke Lisa Federle Peter Martus Peter G. Kremsner Peter G. Kremsner Thirumalaisamy P. Velavan Thirumalaisamy P. Velavan Thirumalaisamy P. Velavan |
| author_facet | Jule Ayran Carsten Köhler Le Thi Kieu Linh Le Thi Kieu Linh Gisela Schneider Srinivas Reddy Pallerla Florian Battke Lisa Federle Peter Martus Peter G. Kremsner Peter G. Kremsner Thirumalaisamy P. Velavan Thirumalaisamy P. Velavan Thirumalaisamy P. Velavan |
| author_sort | Jule Ayran |
| collection | DOAJ |
| description | Despite of contact restrictions, population mobility remains the main reason for the spread of SARS-CoV-2. The state of Baden-Württemberg (BW), Germany, approved a model study in Tübingen (TÜMOD) to evaluate how mandatory rapid diagnostic tests (RDT) could reduce transmission. Between 16 March and 24 April 2021, approximately 165,000 residents and visitors to the city were screened for SARS CoV-2 infection using Abbott Panbio™ COVID-19 Antigen rapid test device. We assessed incidences and recorded epidemiological characteristics in a subset of 4,118 participants recruited at three of the nine testing stations. PCR tests were performed in RDT-positives to determine the positive predictive value (PPV), and circulating variants of SARS-CoV-2 were identified by whole-genome sequencing. 2,282 RDT-negative samples were tested by pooled PCR to calculate the false negative rate (FNR). Viral load was compared between variants. 116 (3%) participants were positive by RDT, and of these, 57 (49%) were positive by PCR, 55 (47%) were negative. This resulted in a PPV of 51%. Of the 57 positives, 52 SARS-CoV-2 genomes were successfully sequenced. Of these, 50 belonged to the B.1.1.7 lineage, which had a high viral load (average Ct = 19). Of the 2,282 RDT negatives tested, all were PCR negative (FNR 0%). At the end of TÜMOD, the incidence in Tübingen, which was initially lower, had reached the incidence in the state of BW. While it is difficult to assess the impact of TÜMOD on incidence independent of confounding factors, further studies are needed to identify the effect of close-meshed testing on infection rates. |
| first_indexed | 2024-03-11T16:03:47Z |
| format | Article |
| id | doaj.art-255da9b28caf40cb8a6c3da77b33473b |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-03-11T16:03:47Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-255da9b28caf40cb8a6c3da77b33473b2023-10-25T06:15:01ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-10-011110.3389/fpubh.2023.11596221159622Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2Jule Ayran0Carsten Köhler1Le Thi Kieu Linh2Le Thi Kieu Linh3Gisela Schneider4Srinivas Reddy Pallerla5Florian Battke6Lisa Federle7Peter Martus8Peter G. Kremsner9Peter G. Kremsner10Thirumalaisamy P. Velavan11Thirumalaisamy P. Velavan12Thirumalaisamy P. Velavan13Institute of Tropical Medicine, Travel Medicine and Human Parasitology, Competence Centre for Tropical Medicine Baden-Württemberg, Universitätsklinikum Tübingen, Tübingen, GermanyInstitute of Tropical Medicine, Travel Medicine and Human Parasitology, Competence Centre for Tropical Medicine Baden-Württemberg, Universitätsklinikum Tübingen, Tübingen, GermanyInstitute of Tropical Medicine, Travel Medicine and Human Parasitology, Competence Centre for Tropical Medicine Baden-Württemberg, Universitätsklinikum Tübingen, Tübingen, GermanyVietnamese-German Center for Medical Research, VG-CARE, Hanoi, VietnamDIFAEM – German Institute for Medical Mission, Tübingen, GermanyInstitute of Tropical Medicine, Travel Medicine and Human Parasitology, Competence Centre for Tropical Medicine Baden-Württemberg, Universitätsklinikum Tübingen, Tübingen, GermanyCenter for Genomics and Transcriptomics (CeGaT) GmbH, Tübingen, GermanyGerman Red Cross, Regional Centre Tübingen, Tübingen, GermanyInstitute for Clinical Epidemiology and Applied Biometry, Universitätsklinikum Tübingen, Tübingen, GermanyInstitute of Tropical Medicine, Travel Medicine and Human Parasitology, Competence Centre for Tropical Medicine Baden-Württemberg, Universitätsklinikum Tübingen, Tübingen, GermanyCentre de Recherches Médicales de Lambaréné (CERMEL), Lambarene, GabonInstitute of Tropical Medicine, Travel Medicine and Human Parasitology, Competence Centre for Tropical Medicine Baden-Württemberg, Universitätsklinikum Tübingen, Tübingen, GermanyVietnamese-German Center for Medical Research, VG-CARE, Hanoi, VietnamFaculty of Medicine, Duy Tan University, Da Nang, VietnamDespite of contact restrictions, population mobility remains the main reason for the spread of SARS-CoV-2. The state of Baden-Württemberg (BW), Germany, approved a model study in Tübingen (TÜMOD) to evaluate how mandatory rapid diagnostic tests (RDT) could reduce transmission. Between 16 March and 24 April 2021, approximately 165,000 residents and visitors to the city were screened for SARS CoV-2 infection using Abbott Panbio™ COVID-19 Antigen rapid test device. We assessed incidences and recorded epidemiological characteristics in a subset of 4,118 participants recruited at three of the nine testing stations. PCR tests were performed in RDT-positives to determine the positive predictive value (PPV), and circulating variants of SARS-CoV-2 were identified by whole-genome sequencing. 2,282 RDT-negative samples were tested by pooled PCR to calculate the false negative rate (FNR). Viral load was compared between variants. 116 (3%) participants were positive by RDT, and of these, 57 (49%) were positive by PCR, 55 (47%) were negative. This resulted in a PPV of 51%. Of the 57 positives, 52 SARS-CoV-2 genomes were successfully sequenced. Of these, 50 belonged to the B.1.1.7 lineage, which had a high viral load (average Ct = 19). Of the 2,282 RDT negatives tested, all were PCR negative (FNR 0%). At the end of TÜMOD, the incidence in Tübingen, which was initially lower, had reached the incidence in the state of BW. While it is difficult to assess the impact of TÜMOD on incidence independent of confounding factors, further studies are needed to identify the effect of close-meshed testing on infection rates.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1159622/fullrapid diagnostic testsSARS-CoV-2COVID-19transmissionTübingen modelB.1.1.7 lineage |
| spellingShingle | Jule Ayran Carsten Köhler Le Thi Kieu Linh Le Thi Kieu Linh Gisela Schneider Srinivas Reddy Pallerla Florian Battke Lisa Federle Peter Martus Peter G. Kremsner Peter G. Kremsner Thirumalaisamy P. Velavan Thirumalaisamy P. Velavan Thirumalaisamy P. Velavan Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2 Frontiers in Public Health rapid diagnostic tests SARS-CoV-2 COVID-19 transmission Tübingen model B.1.1.7 lineage |
| title | Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2 |
| title_full | Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2 |
| title_fullStr | Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2 |
| title_full_unstemmed | Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2 |
| title_short | Tübingen model study: large-scale introduction of rapid antigen testing in the population and the viral dynamics of SARS-CoV-2 |
| title_sort | tubingen model study large scale introduction of rapid antigen testing in the population and the viral dynamics of sars cov 2 |
| topic | rapid diagnostic tests SARS-CoV-2 COVID-19 transmission Tübingen model B.1.1.7 lineage |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1159622/full |
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