Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse
The voltage-gated calcium influxes modulated with terahertz Gaussian pulse is presented in this paper, and temperature rise is evaluated to monitor the terahertz thermal effects involved in the modulation. From the numerical results, inhibition effect on voltage-gated calcium influx because of the l...
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IEEE
2020-01-01
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| Series: | IEEE Access |
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| Online Access: | https://ieeexplore.ieee.org/document/9145579/ |
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| author | Wenfei Bo Lianghao Guo Kaicheng Wang Jialu Ma Jingchao Tang Zhe Wu Baoqing Zeng Yubin Gong |
| author_facet | Wenfei Bo Lianghao Guo Kaicheng Wang Jialu Ma Jingchao Tang Zhe Wu Baoqing Zeng Yubin Gong |
| author_sort | Wenfei Bo |
| collection | DOAJ |
| description | The voltage-gated calcium influxes modulated with terahertz Gaussian pulse is presented in this paper, and temperature rise is evaluated to monitor the terahertz thermal effects involved in the modulation. From the numerical results, inhibition effect on voltage-gated calcium influx because of the loss of the influx from electric drift is transparently revealed in the modulation with terahertz Gaussian pulse. And the inhibition effect becomes significant reflected by considerable reduction in voltage-gated calcium influx as the irradiated amplitude is raised intense enough. Compared to the terahertz sinusoidal wave, Gaussian pulse reduces the inhibition effect dramatically. The decrease in the increment of intracellular calcium concentration with the irradiated amplitude due to the inhibition effect is substantially relieved by the modulation of the calcium influx with terahertz Gaussian pulse. The thermal analyses reveal that the modulation is non-thermal effect. Meanwhile, to raise the intracellular calcium concentration to a same amount by means of the voltage-gated calcium influx, application of terahertz Gaussian pulse induces much less concurrent temperature rise than application of terahertz sinusoidal wave of the same amplitude that is intense enough to cause the inhibition effect. Additionally, terahertz Gaussian pulse irradiation remains the dependence of the increment of the calcium concentration on the irradiated time duration and frequency in terahertz sinusoidal wave irradiation. These numerical results lay the theoretical basis for the modulation of voltage-gated calcium fluxes with terahertz Gaussian pulse and for further potential clinical applications of terahertz Gaussian pulse. |
| first_indexed | 2024-12-20T05:33:03Z |
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| institution | Directory Open Access Journal |
| issn | 2169-3536 |
| language | English |
| last_indexed | 2024-12-20T05:33:03Z |
| publishDate | 2020-01-01 |
| publisher | IEEE |
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| series | IEEE Access |
| spelling | doaj.art-255ed32d0e6248ae92c9446f0d79db8e2022-12-21T19:51:41ZengIEEEIEEE Access2169-35362020-01-01813367313368010.1109/ACCESS.2020.30108709145579Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian PulseWenfei Bo0https://orcid.org/0000-0003-4017-8260Lianghao Guo1https://orcid.org/0000-0001-7522-2722Kaicheng Wang2https://orcid.org/0000-0003-2897-1434Jialu Ma3https://orcid.org/0000-0002-6698-663XJingchao Tang4https://orcid.org/0000-0001-9614-1083Zhe Wu5https://orcid.org/0000-0001-5552-4619Baoqing Zeng6https://orcid.org/0000-0002-2377-5840Yubin Gong7https://orcid.org/0000-0003-3014-1309School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaSchool of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, ChinaThe voltage-gated calcium influxes modulated with terahertz Gaussian pulse is presented in this paper, and temperature rise is evaluated to monitor the terahertz thermal effects involved in the modulation. From the numerical results, inhibition effect on voltage-gated calcium influx because of the loss of the influx from electric drift is transparently revealed in the modulation with terahertz Gaussian pulse. And the inhibition effect becomes significant reflected by considerable reduction in voltage-gated calcium influx as the irradiated amplitude is raised intense enough. Compared to the terahertz sinusoidal wave, Gaussian pulse reduces the inhibition effect dramatically. The decrease in the increment of intracellular calcium concentration with the irradiated amplitude due to the inhibition effect is substantially relieved by the modulation of the calcium influx with terahertz Gaussian pulse. The thermal analyses reveal that the modulation is non-thermal effect. Meanwhile, to raise the intracellular calcium concentration to a same amount by means of the voltage-gated calcium influx, application of terahertz Gaussian pulse induces much less concurrent temperature rise than application of terahertz sinusoidal wave of the same amplitude that is intense enough to cause the inhibition effect. Additionally, terahertz Gaussian pulse irradiation remains the dependence of the increment of the calcium concentration on the irradiated time duration and frequency in terahertz sinusoidal wave irradiation. These numerical results lay the theoretical basis for the modulation of voltage-gated calcium fluxes with terahertz Gaussian pulse and for further potential clinical applications of terahertz Gaussian pulse.https://ieeexplore.ieee.org/document/9145579/Biological effects of electromagnetic radiationGaussiancalcium ionsvoltage-gated calcium channelmodeling and simulations |
| spellingShingle | Wenfei Bo Lianghao Guo Kaicheng Wang Jialu Ma Jingchao Tang Zhe Wu Baoqing Zeng Yubin Gong Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse IEEE Access Biological effects of electromagnetic radiation Gaussian calcium ions voltage-gated calcium channel modeling and simulations |
| title | Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse |
| title_full | Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse |
| title_fullStr | Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse |
| title_full_unstemmed | Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse |
| title_short | Modulation of Voltage-Gated Calcium Influx by Electromagnetic Irradiation With Terahertz Gaussian Pulse |
| title_sort | modulation of voltage gated calcium influx by electromagnetic irradiation with terahertz gaussian pulse |
| topic | Biological effects of electromagnetic radiation Gaussian calcium ions voltage-gated calcium channel modeling and simulations |
| url | https://ieeexplore.ieee.org/document/9145579/ |
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