The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children.
BACKGROUND: Acute lower respiratory infection (ALRI) is a major cause of hospitalization for children in China, while the etiological diagnosis of ALRI remains a challenge. This study was performed to evaluate the utility of the blind Nasotracheal aspiration (NTA) in the pathogen detection in ALRI t...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3012105?pdf=render |
| _version_ | 1829509431896834048 |
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| author | Tao Zhang Steven Black Chuangli Hao Yunfang Ding Wei Ji Rong Chen Yuzun Lin Juhani Eskola Henry Shinefield Maria Delorian Knoll Genming Zhao |
| author_facet | Tao Zhang Steven Black Chuangli Hao Yunfang Ding Wei Ji Rong Chen Yuzun Lin Juhani Eskola Henry Shinefield Maria Delorian Knoll Genming Zhao |
| author_sort | Tao Zhang |
| collection | DOAJ |
| description | BACKGROUND: Acute lower respiratory infection (ALRI) is a major cause of hospitalization for children in China, while the etiological diagnosis of ALRI remains a challenge. This study was performed to evaluate the utility of the blind Nasotracheal aspiration (NTA) in the pathogen detection in ALRI through an evaluation of the test's specificity. METHODOLOGY/PRINCIPAL FINDINGS: A hospital-based study of children ≤3 years was carried out from March 2006 through March 2007 in Suzhou University Affiliated Children's Hospital, including 379 cases with ALRI from the respiratory wards, and 394 controls receiving elective surgery. Nasopharyngeal swabs (NPS) and NTA specimens were taken on admission. S. pneumoniae was isolated from 10.3% of NTA samples from ALRI children, H. influenzae from 15.3%, and M. catarrhalis from 4.7%. The false positive rate--the strains from NTA in control group children--was 8.4% (95% CI: 5.8%-11.4%) for S. pneumoniae, 27.2% (95% CI: 22.7-31.5%) for H. influenzae, and 22.1% (95% CI: 18.0%-26.2%) for M. catarrhalis. The agreement between NPS and NTA in the control group was over 70%. CONCLUSION/SIGNIFICANCE: The blind NTA test is not a useful test for etiologic diagnosis of ALRI. |
| first_indexed | 2024-12-16T11:46:40Z |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T11:46:40Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-255f918dbaaf4db1af3473883c1898dd2022-12-21T22:32:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-01512e1588510.1371/journal.pone.0015885The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children.Tao ZhangSteven BlackChuangli HaoYunfang DingWei JiRong ChenYuzun LinJuhani EskolaHenry ShinefieldMaria Delorian KnollGenming ZhaoBACKGROUND: Acute lower respiratory infection (ALRI) is a major cause of hospitalization for children in China, while the etiological diagnosis of ALRI remains a challenge. This study was performed to evaluate the utility of the blind Nasotracheal aspiration (NTA) in the pathogen detection in ALRI through an evaluation of the test's specificity. METHODOLOGY/PRINCIPAL FINDINGS: A hospital-based study of children ≤3 years was carried out from March 2006 through March 2007 in Suzhou University Affiliated Children's Hospital, including 379 cases with ALRI from the respiratory wards, and 394 controls receiving elective surgery. Nasopharyngeal swabs (NPS) and NTA specimens were taken on admission. S. pneumoniae was isolated from 10.3% of NTA samples from ALRI children, H. influenzae from 15.3%, and M. catarrhalis from 4.7%. The false positive rate--the strains from NTA in control group children--was 8.4% (95% CI: 5.8%-11.4%) for S. pneumoniae, 27.2% (95% CI: 22.7-31.5%) for H. influenzae, and 22.1% (95% CI: 18.0%-26.2%) for M. catarrhalis. The agreement between NPS and NTA in the control group was over 70%. CONCLUSION/SIGNIFICANCE: The blind NTA test is not a useful test for etiologic diagnosis of ALRI.http://europepmc.org/articles/PMC3012105?pdf=render |
| spellingShingle | Tao Zhang Steven Black Chuangli Hao Yunfang Ding Wei Ji Rong Chen Yuzun Lin Juhani Eskola Henry Shinefield Maria Delorian Knoll Genming Zhao The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children. PLoS ONE |
| title | The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children. |
| title_full | The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children. |
| title_fullStr | The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children. |
| title_full_unstemmed | The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children. |
| title_short | The blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children. |
| title_sort | blind nasotracheal aspiration method is not a useful tool for pathogen detection of pneumonia in children |
| url | http://europepmc.org/articles/PMC3012105?pdf=render |
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