Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulida
This paper reports the use of alternative materials for teaching experimental chemistry. In this context, nimesulide and propranolol tablets were used to teach chemical concepts about acid-base reactions according to Brönsted-Lowry protonic Theory. Important topics of Organic, Analytical and Pharmac...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2013-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000800024&lng=en&tlng=en |
| _version_ | 1828461955171483648 |
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| author | Arlan de Assis Gonsalves Cleônia Roberta Melo Araújo Carlos Alberto Leite Filho Felipe Santana de Medeiros |
| author_facet | Arlan de Assis Gonsalves Cleônia Roberta Melo Araújo Carlos Alberto Leite Filho Felipe Santana de Medeiros |
| author_sort | Arlan de Assis Gonsalves |
| collection | DOAJ |
| description | This paper reports the use of alternative materials for teaching experimental chemistry. In this context, nimesulide and propranolol tablets were used to teach chemical concepts about acid-base reactions according to Brönsted-Lowry protonic Theory. Important topics of Organic, Analytical and Pharmaceutical Chemistry were discussed, such as purification by acid-base extraction, solubility of organic compounds in aqueous solutions, buffers, the dissociation constant (pKa), potentiometric titration and ionization of drugs in biological fluids. The purification of propranolol and nimesulide from tablets produced yields of 75% and 90%, respectively. The experimental values of pKa for both drugs were in agreement with those from the literature. |
| first_indexed | 2024-12-11T02:27:51Z |
| format | Article |
| id | doaj.art-255fe589080b43d9901b6f289bb3d2e8 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-11T02:27:51Z |
| publishDate | 2013-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-255fe589080b43d9901b6f289bb3d2e82022-12-22T01:23:53ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642013-01-013681236124110.1590/S0100-40422013000800024S0100-40422013000800024Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulidaArlan de Assis Gonsalves0Cleônia Roberta Melo Araújo1Carlos Alberto Leite Filho2Felipe Santana de Medeiros3Universidade Federal do Vale do São FranciscoUniversidade Federal do Vale do São FranciscoUniversidade Federal do Vale do São FranciscoUniversidade Federal do Vale do São FranciscoThis paper reports the use of alternative materials for teaching experimental chemistry. In this context, nimesulide and propranolol tablets were used to teach chemical concepts about acid-base reactions according to Brönsted-Lowry protonic Theory. Important topics of Organic, Analytical and Pharmaceutical Chemistry were discussed, such as purification by acid-base extraction, solubility of organic compounds in aqueous solutions, buffers, the dissociation constant (pKa), potentiometric titration and ionization of drugs in biological fluids. The purification of propranolol and nimesulide from tablets produced yields of 75% and 90%, respectively. The experimental values of pKa for both drugs were in agreement with those from the literature.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000800024&lng=en&tlng=enacid-base reactionspropranololnimesulide |
| spellingShingle | Arlan de Assis Gonsalves Cleônia Roberta Melo Araújo Carlos Alberto Leite Filho Felipe Santana de Medeiros Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulida Química Nova acid-base reactions propranolol nimesulide |
| title | Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulida |
| title_full | Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulida |
| title_fullStr | Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulida |
| title_full_unstemmed | Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulida |
| title_short | Contextualizando reações ácido-base de acordo com a teoria protônica de Brönsted-Lowry usando comprimidos de propranolol e nimesulida |
| title_sort | contextualizando reacoes acido base de acordo com a teoria protonica de bronsted lowry usando comprimidos de propranolol e nimesulida |
| topic | acid-base reactions propranolol nimesulide |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000800024&lng=en&tlng=en |
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