A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis
B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common type of ALL, has an excellent prognosis with long-term event-free survival of 90%. The malignancy has several genetic abnormalities that may influence patient prognosis. Rearrangements of the three immunoglobulin genes...
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| Format: | Article |
| Language: | English |
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The Korean Society of Pediatric Hematology-Oncology
2022-10-01
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| Series: | Clinical Pediatric Hematology-Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.15264/cpho.2022.29.2.89 |
| _version_ | 1811256940236374016 |
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| author | Jianne Lee Sun Young Kim Yeon Jung Lim |
| author_facet | Jianne Lee Sun Young Kim Yeon Jung Lim |
| author_sort | Jianne Lee |
| collection | DOAJ |
| description | B-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common type of ALL, has an excellent prognosis with long-term event-free survival of 90%. The malignancy has several genetic abnormalities that may influence patient prognosis. Rearrangements of the three immunoglobulin genes IGK(2p12), IGH(14q32), and IGL(22q11) are often seen, especially in non-Hodgkin lymphoma (NHL), but recombination of these genes are uncommon. The translocation, t(14;22)(q32;q11) has been reported in only 9 B-cell leukemia/lymphoma cases, but there has been no report about the clinical feature and prognosis of BCP-ALL with t(14;22)(q32;q11). In this paper, we describe the first pediatric case of BCP-ALL with t(14;22)(q32;q11) who presented with a very high white blood cell (WBC) count. He achieved cytogenetic complete remission after induction chemotherapy, and negative minimal residual disease (MRD) at the end of consolidation. |
| first_indexed | 2024-04-12T17:48:52Z |
| format | Article |
| id | doaj.art-256052005adc4494af5b60006717a14a |
| institution | Directory Open Access Journal |
| issn | 2233-5250 |
| language | English |
| last_indexed | 2024-04-12T17:48:52Z |
| publishDate | 2022-10-01 |
| publisher | The Korean Society of Pediatric Hematology-Oncology |
| record_format | Article |
| series | Clinical Pediatric Hematology-Oncology |
| spelling | doaj.art-256052005adc4494af5b60006717a14a2022-12-22T03:22:34ZengThe Korean Society of Pediatric Hematology-OncologyClinical Pediatric Hematology-Oncology2233-52502022-10-01292899110.15264/cpho.2022.29.2.89cpho.2022.29.2.89A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting HyperleukocytosisJianne Lee0Sun Young Kim1Yeon Jung Lim2Department of Pediatrics, Chungnam National University Hospital, Daejeon, KoreaDepartment of Laboratory Medicine, Chungnam National University Hospital, Daejeon, KoreaDepartment of Pediatrics, Chungnam National University Hospital, Daejeon, KoreaB-cell precursor acute lymphoblastic leukemia (BCP-ALL), which is the most common type of ALL, has an excellent prognosis with long-term event-free survival of 90%. The malignancy has several genetic abnormalities that may influence patient prognosis. Rearrangements of the three immunoglobulin genes IGK(2p12), IGH(14q32), and IGL(22q11) are often seen, especially in non-Hodgkin lymphoma (NHL), but recombination of these genes are uncommon. The translocation, t(14;22)(q32;q11) has been reported in only 9 B-cell leukemia/lymphoma cases, but there has been no report about the clinical feature and prognosis of BCP-ALL with t(14;22)(q32;q11). In this paper, we describe the first pediatric case of BCP-ALL with t(14;22)(q32;q11) who presented with a very high white blood cell (WBC) count. He achieved cytogenetic complete remission after induction chemotherapy, and negative minimal residual disease (MRD) at the end of consolidation.https://doi.org/10.15264/cpho.2022.29.2.89acute lymphoblastic leukemiachromosome aberrationschildprecursor cell lymphoblastic leukemia-lymphoma |
| spellingShingle | Jianne Lee Sun Young Kim Yeon Jung Lim A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis Clinical Pediatric Hematology-Oncology acute lymphoblastic leukemia chromosome aberrations child precursor cell lymphoblastic leukemia-lymphoma |
| title | A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis |
| title_full | A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis |
| title_fullStr | A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis |
| title_full_unstemmed | A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis |
| title_short | A Case of B-cell Precursor Acute Lymphoblastic Leukemia with the t(14;22)(q32;q11) Presenting Hyperleukocytosis |
| title_sort | case of b cell precursor acute lymphoblastic leukemia with the t 14 22 q32 q11 presenting hyperleukocytosis |
| topic | acute lymphoblastic leukemia chromosome aberrations child precursor cell lymphoblastic leukemia-lymphoma |
| url | https://doi.org/10.15264/cpho.2022.29.2.89 |
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