Induction therapy with ipilimumab and nivolumab followed by consolidative chemoradiation as organ-sparing treatment in urothelial bladder cancer: study protocol of the INDIBLADE trial

Induction therapy with ipilimumab and nivolumab followed by consolidative chemoradiation as organ-sparing treatment in urothelial bladder cancer: study protocol of the INDIBLADE trial

IntroductionStudies that assessed the efficacy of pre-operative immune checkpoint blockade (ICB) in locally advanced urothelial cancer of the bladder showed encouraging pathological complete response rates, suggesting that a bladder-sparing approach may be a viable option in a subset of patients. Ch...

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Bibliographic Details
Main Authors: C.F. Stockem, J.J.J. Mellema, B.W.G. van Rhijn, T.N. Boellaard, M.L. van Montfoort, S. Balduzzi, J.L. Boormans, M. Franckena, R.P. Meijer, D.G.J. Robbrecht, B.B.M. Suelmann, E.E. Schaake, M.S. van der Heijden
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
Muscle-invasive bladder cancer
bladder preservation
immune checkpoint blockade
chemoradiation
trimodal therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1246603/full

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