Overestimated prediction using polygenic prediction derived from summary statistics

Overestimated prediction using polygenic prediction derived from summary statistics

Abstract Background When polygenic risk score (PRS) is derived from summary statistics, independence between discovery and test sets cannot be monitored. We compared two types of PRS studies derived from raw genetic data (denoted as rPRS) and the summary statistics for IGAP (sPRS). Results Two varia...

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Bibliographic Details
Main Authors: David Keetae Park, Mingshen Chen, Seungsoo Kim, Yoonjung Yoonie Joo, Rebekah K. Loving, Hyoung Seop Kim, Jiook Cha, Shinjae Yoo, Jong Hun Kim
Format: Article
Language:English
Published: BMC 2023-09-01
Series:BMC Genomic Data
Subjects:
Polygenic risk score
Complex genetic disease
Alzheimer’s disease
Overestimation bias
Online Access:https://doi.org/10.1186/s12863-023-01151-4

Internet

https://doi.org/10.1186/s12863-023-01151-4

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