Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography
Cerebral edema is a serious complication of ischemic cerebrovascular disease and mannitol is a commonly used dehydrating agent for relieving cerebral edema. However, the edema state and surrounding vascular perfusion level during mannitol treatment remains unclear, which affects the clinical applica...
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MDPI AG
2022-01-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/9/2/81 |
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| author | Zhenhe Ma Ziyue Meng Yifu Tian Jian Liu Ang Li Yang Lin Yao Yu Jingmin Luan Hongtu Wang Yuqian Zhao Yi Wang |
| author_facet | Zhenhe Ma Ziyue Meng Yifu Tian Jian Liu Ang Li Yang Lin Yao Yu Jingmin Luan Hongtu Wang Yuqian Zhao Yi Wang |
| author_sort | Zhenhe Ma |
| collection | DOAJ |
| description | Cerebral edema is a serious complication of ischemic cerebrovascular disease and mannitol is a commonly used dehydrating agent for relieving cerebral edema. However, the edema state and surrounding vascular perfusion level during mannitol treatment remains unclear, which affects the clinical application of the medicine. In this paper, we demonstrated the role of swept-source optical coherence tomography (OCT) in the evaluation of mannitol efficacy using mouse models. The OCT-based angiography and attenuation imaging technology were used to obtain the cerebral vascular perfusion level and cerebral edema state at different times. Vascular parameters and edema parameters were quantified and compared. Experimental results show that mannitol can significantly reduce the water content in the central region of edema, effectively inhibiting the rapid growth of the edema area, and restoring cerebral blood flow. On average, the edema area decreased by 33% after 2 h, and the vascular perfusion density increased by 12% after 5 h. This work helps to provide a valuable theoretical basis and research ideas for the clinical treatment of cerebral edema. |
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| institution | Directory Open Access Journal |
| issn | 2304-6732 |
| language | English |
| last_indexed | 2024-03-09T21:12:44Z |
| publishDate | 2022-01-01 |
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| series | Photonics |
| spelling | doaj.art-2562a2d6e5a64c3eba6dfea9866c8e7c2023-11-23T21:41:11ZengMDPI AGPhotonics2304-67322022-01-01928110.3390/photonics9020081Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence TomographyZhenhe Ma0Ziyue Meng1Yifu Tian2Jian Liu3Ang Li4Yang Lin5Yao Yu6Jingmin Luan7Hongtu Wang8Yuqian Zhao9Yi Wang10School of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaDepartment of Neurosurgery, The First Hospital of Qinhuangdao, Qinhuangdao 066004, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaSchool of Computer and Communication Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaDepartment of Rehabilitation Medicine, Tianjin Huanhu Hospital, Tianjin 300350, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaSchool of Control Engineering, Northeastern University at Qinhuangdao, Qinhuangdao 066004, ChinaCerebral edema is a serious complication of ischemic cerebrovascular disease and mannitol is a commonly used dehydrating agent for relieving cerebral edema. However, the edema state and surrounding vascular perfusion level during mannitol treatment remains unclear, which affects the clinical application of the medicine. In this paper, we demonstrated the role of swept-source optical coherence tomography (OCT) in the evaluation of mannitol efficacy using mouse models. The OCT-based angiography and attenuation imaging technology were used to obtain the cerebral vascular perfusion level and cerebral edema state at different times. Vascular parameters and edema parameters were quantified and compared. Experimental results show that mannitol can significantly reduce the water content in the central region of edema, effectively inhibiting the rapid growth of the edema area, and restoring cerebral blood flow. On average, the edema area decreased by 33% after 2 h, and the vascular perfusion density increased by 12% after 5 h. This work helps to provide a valuable theoretical basis and research ideas for the clinical treatment of cerebral edema.https://www.mdpi.com/2304-6732/9/2/81swept source optical coherence tomographyischemic strokecerebral edemamannitoloptical attenuation coefficient |
| spellingShingle | Zhenhe Ma Ziyue Meng Yifu Tian Jian Liu Ang Li Yang Lin Yao Yu Jingmin Luan Hongtu Wang Yuqian Zhao Yi Wang Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography Photonics swept source optical coherence tomography ischemic stroke cerebral edema mannitol optical attenuation coefficient |
| title | Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography |
| title_full | Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography |
| title_fullStr | Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography |
| title_full_unstemmed | Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography |
| title_short | Evaluation of Mannitol Intervention Effects on Ischemic Cerebral Edema in Mice Using Swept Source Optical Coherence Tomography |
| title_sort | evaluation of mannitol intervention effects on ischemic cerebral edema in mice using swept source optical coherence tomography |
| topic | swept source optical coherence tomography ischemic stroke cerebral edema mannitol optical attenuation coefficient |
| url | https://www.mdpi.com/2304-6732/9/2/81 |
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