Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention

Decellularized nucleus pulposus matrix/chitosan hybrid hydrogel combined with nucleus pulposus stem cells and GDF5-loaded microspheres for intervertebral disc degeneration prevention

Abstract Background Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the normal biological properties of disc units. In this study, hydrogels loade...

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Bibliographic Details
Main Authors: Tao Ma, Chen Liu, Quanlai Zhao, Yu Zhang, Liang Xiao
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Molecular Medicine
Subjects:
Intervertebral disc degeneration
NPSC
Decellularized nucleus pulposus matrix
Chitosan
Microspheres
GDF5
Online Access:https://doi.org/10.1186/s10020-024-00777-z

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