Acid- and Volume-Sensitive Chloride Currents in Human Chondrocytes

Acid- and Volume-Sensitive Chloride Currents in Human Chondrocytes

Chondrocytes face extreme alterations of extracellular osmolarity and pH, which force them to appropriately regulate their cell volume (CV) and cellular pH. Perturbations of these mechanisms lead to chondrocyte death and ultimately to osteoarthritis (OA), the most common chronic joint diseases world...

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Bibliographic Details
Main Authors: Michael Kittl, Martina Winklmayr, Katharina Helm, Johannes Lettner, Martin Gaisberger, Markus Ritter, Martin Jakab
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
acidic
chloride
current
chondrocytes
osteoarthritis
pH
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.583131/full

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