Cyclo- and Polyphosphazenes for Biomedical Applications
Cyclic and polyphosphazenes are extremely interesting and versatile substrates characterized by the presence of -P=N- repeating units. The chlorine atoms on the P atoms in the starting materials can be easily substituted with a variety of organic substituents, thus giving rise to a huge number of ne...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/23/8117 |
| _version_ | 1797462704031531008 |
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| author | Girolamo Casella Silvia Carlotto Francesco Lanero Mirto Mozzon Paolo Sgarbossa Roberta Bertani |
| author_facet | Girolamo Casella Silvia Carlotto Francesco Lanero Mirto Mozzon Paolo Sgarbossa Roberta Bertani |
| author_sort | Girolamo Casella |
| collection | DOAJ |
| description | Cyclic and polyphosphazenes are extremely interesting and versatile substrates characterized by the presence of -P=N- repeating units. The chlorine atoms on the P atoms in the starting materials can be easily substituted with a variety of organic substituents, thus giving rise to a huge number of new materials for industrial applications. Their properties can be designed considering the number of repetitive units and the nature of the substituent groups, opening up to a number of peculiar properties, including the ability to give rise to supramolecular arrangements. We focused our attention on the extensive scientific literature concerning their biomedical applications: as antimicrobial agents in drug delivery, as immunoadjuvants in tissue engineering, in innovative anticancer therapies, and treatments for cardiovascular diseases. The promising perspectives for their biomedical use rise from the opportunity to combine the benefits of the inorganic backbone and the wide variety of organic side groups that can lead to the formation of nanoparticles, polymersomes, or scaffolds for cell proliferation. In this review, some aspects of the preparation of phosphazene-based systems and their characterization, together with some of the most relevant chemical strategies to obtain biomaterials, have been described. |
| first_indexed | 2024-03-09T17:40:25Z |
| format | Article |
| id | doaj.art-256626005585453399c3e5f4fc2577fa |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T17:40:25Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-256626005585453399c3e5f4fc2577fa2023-11-24T11:36:52ZengMDPI AGMolecules1420-30492022-11-012723811710.3390/molecules27238117Cyclo- and Polyphosphazenes for Biomedical ApplicationsGirolamo Casella0Silvia Carlotto1Francesco Lanero2Mirto Mozzon3Paolo Sgarbossa4Roberta Bertani5Department of Earth and Marine Sciences (DiSTeM), University of Palermo, Via Archirafi 22, 90123 Palermo, ItalyDepartment of Chemical Sciences (DiSC), University of Padova, Via F. Marzolo 1, 35131 Padova, ItalyDepartment of Industrial Engineering, University of Padova, Via F. Marzolo 1, 35131 Padova, ItalyDepartment of Industrial Engineering, University of Padova, Via F. Marzolo 1, 35131 Padova, ItalyDepartment of Industrial Engineering, University of Padova, Via F. Marzolo 1, 35131 Padova, ItalyDepartment of Industrial Engineering, University of Padova, Via F. Marzolo 1, 35131 Padova, ItalyCyclic and polyphosphazenes are extremely interesting and versatile substrates characterized by the presence of -P=N- repeating units. The chlorine atoms on the P atoms in the starting materials can be easily substituted with a variety of organic substituents, thus giving rise to a huge number of new materials for industrial applications. Their properties can be designed considering the number of repetitive units and the nature of the substituent groups, opening up to a number of peculiar properties, including the ability to give rise to supramolecular arrangements. We focused our attention on the extensive scientific literature concerning their biomedical applications: as antimicrobial agents in drug delivery, as immunoadjuvants in tissue engineering, in innovative anticancer therapies, and treatments for cardiovascular diseases. The promising perspectives for their biomedical use rise from the opportunity to combine the benefits of the inorganic backbone and the wide variety of organic side groups that can lead to the formation of nanoparticles, polymersomes, or scaffolds for cell proliferation. In this review, some aspects of the preparation of phosphazene-based systems and their characterization, together with some of the most relevant chemical strategies to obtain biomaterials, have been described.https://www.mdpi.com/1420-3049/27/23/8117cyclophosphazenespolyphosphazenesdrug deliverytissue engineering |
| spellingShingle | Girolamo Casella Silvia Carlotto Francesco Lanero Mirto Mozzon Paolo Sgarbossa Roberta Bertani Cyclo- and Polyphosphazenes for Biomedical Applications Molecules cyclophosphazenes polyphosphazenes drug delivery tissue engineering |
| title | Cyclo- and Polyphosphazenes for Biomedical Applications |
| title_full | Cyclo- and Polyphosphazenes for Biomedical Applications |
| title_fullStr | Cyclo- and Polyphosphazenes for Biomedical Applications |
| title_full_unstemmed | Cyclo- and Polyphosphazenes for Biomedical Applications |
| title_short | Cyclo- and Polyphosphazenes for Biomedical Applications |
| title_sort | cyclo and polyphosphazenes for biomedical applications |
| topic | cyclophosphazenes polyphosphazenes drug delivery tissue engineering |
| url | https://www.mdpi.com/1420-3049/27/23/8117 |
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