<i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy
Diabetic retinopathy (DR) is a leading complication in type 1 and type 2 diabetes and has emerged as a significant health problem. Currently, there are no effective therapeutic strategies owing to its inconspicuous early lesions and complex pathological mechanisms. Therefore, the mechanism of molecu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/8/725 |
| _version_ | 1797408898361065472 |
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| author | Chengzhi Liu Wenkang Dong Jun Li Ying Kong Xiang Ren |
| author_facet | Chengzhi Liu Wenkang Dong Jun Li Ying Kong Xiang Ren |
| author_sort | Chengzhi Liu |
| collection | DOAJ |
| description | Diabetic retinopathy (DR) is a leading complication in type 1 and type 2 diabetes and has emerged as a significant health problem. Currently, there are no effective therapeutic strategies owing to its inconspicuous early lesions and complex pathological mechanisms. Therefore, the mechanism of molecular pathogenesis requires further elucidation to identify potential targets that can aid in the prevention of DR. As a type of protein translational modification, <i>O</i>-linked β-N-acetylglucosamine (<i>O</i>-GlcNAc) modification is involved in many diseases, and increasing evidence suggests that dysregulated <i>O</i>-GlcNAc modification is associated with DR. The present review discusses <i>O</i>-GlcNAc modification and its molecular mechanisms involved in DR. <i>O</i>-GlcNAc modification might represent a novel alternative therapeutic target for DR in the future. |
| first_indexed | 2024-03-09T04:06:18Z |
| format | Article |
| id | doaj.art-256913ed2a7d494ba9b5bd94814977fe |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T04:06:18Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-256913ed2a7d494ba9b5bd94814977fe2023-12-03T14:06:15ZengMDPI AGMetabolites2218-19892022-08-0112872510.3390/metabo12080725<i>O</i>-GlcNAc Modification and Its Role in Diabetic RetinopathyChengzhi Liu0Wenkang Dong1Jun Li2Ying Kong3Xiang Ren4The First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaDepartment of Histology and Embryology, College of Basic Medicine, Dalian Medical University, Dalian 116044, ChinaThe First Affiliated Hospital of Dalian Medical University, Dalian 116011, ChinaCore Laboratory of Glycobiology and Glycoengineering, College of Basic Medicine, Dalian Medical University, Dalian 116044, ChinaDepartment of Histology and Embryology, College of Basic Medicine, Dalian Medical University, Dalian 116044, ChinaDiabetic retinopathy (DR) is a leading complication in type 1 and type 2 diabetes and has emerged as a significant health problem. Currently, there are no effective therapeutic strategies owing to its inconspicuous early lesions and complex pathological mechanisms. Therefore, the mechanism of molecular pathogenesis requires further elucidation to identify potential targets that can aid in the prevention of DR. As a type of protein translational modification, <i>O</i>-linked β-N-acetylglucosamine (<i>O</i>-GlcNAc) modification is involved in many diseases, and increasing evidence suggests that dysregulated <i>O</i>-GlcNAc modification is associated with DR. The present review discusses <i>O</i>-GlcNAc modification and its molecular mechanisms involved in DR. <i>O</i>-GlcNAc modification might represent a novel alternative therapeutic target for DR in the future.https://www.mdpi.com/2218-1989/12/8/725<i>O</i>-linked β-N-acetylglucosamine modificationdiabetic retinopathyhexosamine biosynthetic pathwayretinal microvascular lesionsneurodegeneration |
| spellingShingle | Chengzhi Liu Wenkang Dong Jun Li Ying Kong Xiang Ren <i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy Metabolites <i>O</i>-linked β-N-acetylglucosamine modification diabetic retinopathy hexosamine biosynthetic pathway retinal microvascular lesions neurodegeneration |
| title | <i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy |
| title_full | <i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy |
| title_fullStr | <i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy |
| title_full_unstemmed | <i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy |
| title_short | <i>O</i>-GlcNAc Modification and Its Role in Diabetic Retinopathy |
| title_sort | i o i glcnac modification and its role in diabetic retinopathy |
| topic | <i>O</i>-linked β-N-acetylglucosamine modification diabetic retinopathy hexosamine biosynthetic pathway retinal microvascular lesions neurodegeneration |
| url | https://www.mdpi.com/2218-1989/12/8/725 |
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