Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells

Activation of the integrated stress response is a vulnerability for multidrug‐resistant FBXW7‐deficient cells

Abstract FBXW7 is one of the most frequently mutated tumor suppressors, deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatics and genome‐wide CRISPR screens, we here reveal that FBXW7 deficiency leads to multidrug resistance (MDR). Proteomic ana...

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Bibliographic Details
Main Authors: Laura Sanchez‐Burgos, Belén Navarro‐González, Santiago García‐Martín, Oleksandra Sirozh, Jorge Mota‐Pino, Elena Fueyo‐Marcos, Héctor Tejero, Marta Elena Antón, Matilde Murga, Fátima Al‐Shahrour, Oscar Fernandez‐Capetillo
Format: Article
Language:English
Published: Springer Nature 2022-07-01
Series:EMBO Molecular Medicine
Subjects:
drug resistance
FBXW7
GCN2
ISR
mitochondria
Online Access:https://doi.org/10.15252/emmm.202215855

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