Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study
The management of prostate biopsy in men with clinical suspicion of prostate cancer has changed in the last few years, especially with the introduction of imaging techniques, to overcome the low efficacy of risk stratification based on PSA levels. Here, we aimed to compare the diagnostic accuracy of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/19/4833 |
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| author | Andrea Fulco Francesco Chiaradia Luigi Ascalone Vincenzo Andracchio Antonio Greco Manlio Cappa Marcello Scarcia Giuseppe Mario Ludovico Vincenzo Pagliarulo Camillo Palmieri Stefano Alba |
| author_facet | Andrea Fulco Francesco Chiaradia Luigi Ascalone Vincenzo Andracchio Antonio Greco Manlio Cappa Marcello Scarcia Giuseppe Mario Ludovico Vincenzo Pagliarulo Camillo Palmieri Stefano Alba |
| author_sort | Andrea Fulco |
| collection | DOAJ |
| description | The management of prostate biopsy in men with clinical suspicion of prostate cancer has changed in the last few years, especially with the introduction of imaging techniques, to overcome the low efficacy of risk stratification based on PSA levels. Here, we aimed to compare the diagnostic accuracy of multiparametric MRI with fusion ultrasound-guided prostate biopsy and standard biopsy, both performed through the transperineal route. To this end, we retrospectively analyzed 272 patients who underwent combined transperineal targeted and standard biopsy during the same session. The primary outcome was to compare the cancer detection rate between targeted and standard biopsy. The secondary outcome was to evaluate the added value of combined targeted and standard biopsy approach as compared to only targeted or standard biopsy. Results showed that a rate of 16.7% clinically significant tumors (International Society of Urological Pathology (ISUP) grade ≥ 2) would have been lost if only the standard biopsy had been used. The combined targeted and standard biopsy showed an added value of 10.3% and 9.9% in reducing the risk of prostate cancer missing after targeted or standard biopsy alone, respectively. The combined targeted and standard biopsy pathway is recommended to reduce the risk of missing clinically significant prostate cancer. |
| first_indexed | 2024-03-10T07:04:31Z |
| format | Article |
| id | doaj.art-256a95e2ced242eaaa61e70f1e869ed7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:04:31Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-256a95e2ced242eaaa61e70f1e869ed72023-11-22T15:53:02ZengMDPI AGCancers2072-66942021-09-011319483310.3390/cancers13194833Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective StudyAndrea Fulco0Francesco Chiaradia1Luigi Ascalone2Vincenzo Andracchio3Antonio Greco4Manlio Cappa5Marcello Scarcia6Giuseppe Mario Ludovico7Vincenzo Pagliarulo8Camillo Palmieri9Stefano Alba10Department of Urology, Romolo Hospital, 88821 Rocca di Neto, ItalyDepartment of Urology, Romolo Hospital, 88821 Rocca di Neto, ItalyDepartment of Urology, Romolo Hospital, 88821 Rocca di Neto, ItalyDepartment of Urology, Romolo Hospital, 88821 Rocca di Neto, ItalyDepartment of Urology, Romolo Hospital, 88821 Rocca di Neto, ItalyDepartment of Urology, Romolo Hospital, 88821 Rocca di Neto, ItalyDepartment of Urology, Ente Ecclesiastico Ospedale Generale Regionale “F. Miulli”, 70021 Acquaviva delle Fonti, ItalyDepartment of Urology, Ente Ecclesiastico Ospedale Generale Regionale “F. Miulli”, 70021 Acquaviva delle Fonti, ItalyDepartment of Urology, Ospedale Vito Fazzi, 73100 Lecce, ItalyDepartment of Clinical and Experimental Medicine, University Magna Grecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Urology, Romolo Hospital, 88821 Rocca di Neto, ItalyThe management of prostate biopsy in men with clinical suspicion of prostate cancer has changed in the last few years, especially with the introduction of imaging techniques, to overcome the low efficacy of risk stratification based on PSA levels. Here, we aimed to compare the diagnostic accuracy of multiparametric MRI with fusion ultrasound-guided prostate biopsy and standard biopsy, both performed through the transperineal route. To this end, we retrospectively analyzed 272 patients who underwent combined transperineal targeted and standard biopsy during the same session. The primary outcome was to compare the cancer detection rate between targeted and standard biopsy. The secondary outcome was to evaluate the added value of combined targeted and standard biopsy approach as compared to only targeted or standard biopsy. Results showed that a rate of 16.7% clinically significant tumors (International Society of Urological Pathology (ISUP) grade ≥ 2) would have been lost if only the standard biopsy had been used. The combined targeted and standard biopsy showed an added value of 10.3% and 9.9% in reducing the risk of prostate cancer missing after targeted or standard biopsy alone, respectively. The combined targeted and standard biopsy pathway is recommended to reduce the risk of missing clinically significant prostate cancer.https://www.mdpi.com/2072-6694/13/19/4833image-guidedmagnetic resonance imagingultrasonographyprostatic neoplasmsbiopsy |
| spellingShingle | Andrea Fulco Francesco Chiaradia Luigi Ascalone Vincenzo Andracchio Antonio Greco Manlio Cappa Marcello Scarcia Giuseppe Mario Ludovico Vincenzo Pagliarulo Camillo Palmieri Stefano Alba Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study Cancers image-guided magnetic resonance imaging ultrasonography prostatic neoplasms biopsy |
| title | Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study |
| title_full | Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study |
| title_fullStr | Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study |
| title_full_unstemmed | Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study |
| title_short | Multiparametric Magnetic Resonance Imaging-Ultrasound Fusion Transperineal Prostate Biopsy: Diagnostic Accuracy from a Single Center Retrospective Study |
| title_sort | multiparametric magnetic resonance imaging ultrasound fusion transperineal prostate biopsy diagnostic accuracy from a single center retrospective study |
| topic | image-guided magnetic resonance imaging ultrasonography prostatic neoplasms biopsy |
| url | https://www.mdpi.com/2072-6694/13/19/4833 |
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